Intragastric Administration of Casein Leads to Nigrostriatal Disease Progressed Accompanied with Persistent Nigrostriatal—Intestinal Inflammation Activited and Intestinal Microbiota—Metabolic Disorders Induced in MPTP Mouse Model of Parkinson’s Disease

Liu, Xinrong; Liu, Shuya; Tang, Yong; Pu, Zhengjia; Xiao, Hong; Gao, Jieying; Yin, Qi; Jia, Yan; Bai, Qunhua

doi:10.1007/s11064-021-03293-2

Cited by 13 publications

(11 citation statements)

References 111 publications

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“…Gut microbiota could be influenced by many factors, such as dietary habit and antibiotic agents ( Farag et al., 2020 ; Khan et al., 2020 ; Dordević et al., 2021 ; Liu et al., 2021 ). Madison et al.…”

Section: Discussionmentioning

confidence: 99%

Differential Gut Microbiota Compositions Related With the Severity of Major Depressive Disorder

Zhong

Chen

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectiveIncreasing evidence shows a close relationship between gut microbiota and major depressive disorder (MDD), but the specific mechanisms remain unknown. This study was conducted to explore differential gut microbiota compositions related to the severity of MDD.MethodsHealthy controls (HC) (n = 131) and MDD patients (n = 130) were included. MDD patients with Hamilton Depression Rating Scale (HDRS) score <25 and ≥25 were assigned into moderate (n = 72) and severe (n = 58) MDD groups, respectively. Univariate and multivariate analyses were used to analyze the gut microbiota compositions at the genus level.ResultsThirty-six and 27 differential genera were identified in moderate and severe MDD patients, respectively. The differential genera in moderate and severe MDD patients mainly belonged to three (Firmicutes, Actinobacteriota, and Bacteroidota) and two phyla (Firmicutes and Bacteroidota), respectively. One specific covarying network from phylum Actinobacteriota was identified in moderate MDD patients. In addition, five genera (Collinsella, Eggerthella, Alistipes, Faecalibacterium, and Flavonifractor) from the shared differential genera by two MDD groups had a fair efficacy in diagnosing MDD from HC (AUC = 0.786).ConclusionsOur results were helpful for further exploring the role of gut microbiota in the pathogenesis of depression and developing objective diagnostic methods for MDD.

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Section: Discussionmentioning

confidence: 99%

Differential Gut Microbiota Compositions Related With the Severity of Major Depressive Disorder

Zhong

Chen

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Although microbiome studies in animal models of PD has only just began, the results clearly indicate that the gut microbiota in MPTP-induced mice is altered (Fang et al 2019 ; Pu et al 2019 ; Liu et al 2021 ; Sun et al 2021 ; Wang et al 2021 ). MPTP mouse model of PD, therefore, has been extensively used to understand the GBA and to investigate possible therapeutics for PD.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence suggests that alterations in the gastrointestinal microbiota play an important role in onset, progression, and risk of neurodegenerative diseases such as Alzheimer diseases and PD (Pellegrini et al 2018 ; Santos et al 2019 ; Morais et al 2021 ; Rani and Mondal 2021 ). Recently the MPTP mouse models for PD studies have been commonly used to explore the GBA in PD and investigate possible gut microbiota-associated PD therapeutics (Fang et al 2019 ; Pu et al 2019 ; Liu et al 2021 ; Sun et al 2021 ; Wang et al 2021 ). However, there have been conflicting reports for the alteration of bacterial populations in MPTP induced mouse models of PD likely due to different MPTP administration schedules as well as different mouse strain, age, sex, body weight which impact the MPTP effectivity and sensitivity (Lai et al 2018 ; Sun et al 2018 ; Fang et al 2019 ; Pu et al 2019 ; Liao et al 2020 ; Liu et al 2021 ; Wang et al 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Among various animal models, MPTP model does not require surgery or experimental technology and yields a reproducible dopaminergic damage in nigrostriatal pathway. MPTP, therefore, provides one of the most purposive approaches to investigate critical aspects of PD in animal models and has been widely used as an agent to induce PD like symptoms to explore the progression of the disease as well as developing symptomatic and neuroprotective drugs (Lai et al 2018 ; Fang et al 2019 ; Liu et al 2021 ). MPTP is a neurotoxin precursor of 1-methyl-4-phenylpyridinium (MPP +) that induces neurodopaminergic cell death mostly in striatum and SNc, similar to that seen in patients with PD (Prasad and Hung 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…The number of reviews and research papers on MPTP mouse models for PD has steadily increased over the past decades. Recently in-vivo gut microbiota studies for PD also have been performed with MPTP; however, there have been conflicting reports for the alteration of bacterial populations in MPTP-induced mouse models including Firmicutes, Proteobacteria, Lachnospiraceae , Bacteroidetes, Akkermansia , Lactobacillus , and Bacteroides which were increased in some studies while decreased in others (Lai et al 2018 ; Sun et al 2018 , 2021 ; Fang et al 2019 ; Pu et al 2019 ; Liao et al 2020 ; Liu et al 2021 ; Wang et al 2021 , 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Gut Microbial Alteration in MPTP Mouse Model of Parkinson Disease is Administration Regimen Dependent

Aktaş

2023

Cell Mol Neurobiol

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Parkinson Disease (PD) is one of the most common neurodegenerative disorders characterized by loss of dopaminergic neurons involved in motor functions. Growing evidence indicates that gut microbiota communicates with the brain known as the gut-brain axis (GBA). Mitochondrial toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is commonly used in animal studies to investigate the GBA in PD. Various MPTP administration regimens are performed in PD mouse models involving one to multiple injections in 1 day or one injection per day for several days. The aim of this study is to investigate if the impact of MPTP on gut microbiota differs depending on the administration regimen. C57BL/6 mice were treated with acute or subchronic regimens of MPTP. Motor functions were assessed by open-field, catalepsy, and wire hanging tests. The cecum and the brain samples were obtained for microbiota and gene expression analyses, respectively. MPTP administration regimens differed in their ability to alter the gut microbiota. Firmicutes and Bacteroidota were both increased in subchronic mice while did not change and decreased, respectively, in acute mice. Verrucomicrobiota was elevated in acute MPTP mice but dropped in subchronic MPTP mice. Muribaculaceae was the predominant genus in all groups but acute mice. In acute mice, Akkermansia was increased and Colidextribacter was decreased; however, they showed an opposite trend in subchronic mice. These data suggest that MPTP mouse model cause a gut microbiota dysbiosis in an administration regimen dependent manner, and it is important to take consideration of mouse model to investigate the GBA in neurodegenerative diseases including PD. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s10571-023-01319-7.

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Differentiation and regulation of CD4+ T cell subsets in Parkinson’s disease

Sun,

Gu,

Bai

2024

Cell. Mol. Life Sci.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease, and its hallmark pathological features are the loss of dopaminergic (DA) neurons in the midbrain substantia nigra pars compacta (SNpc) and the accumulation of alpha-synuclein (α-syn). It has been shown that the integrity of the blood-brain barrier (BBB) is damaged in PD patients, and a large number of infiltrating T cells and inflammatory cytokines have been detected in the cerebrospinal fluid (CSF) and brain parenchyma of PD patients and PD animal models, including significant change in the number and proportion of different CD4 + T cell subsets. This suggests that the neuroinflammatory response caused by CD4 + T cells is an important risk factor for the development of PD. Here, we systematically review the differentiation of CD4 + T cell subsets, and focus on describing the functions and mechanisms of different CD4 + T cell subsets and their secreted cytokines in PD. We also summarize the current immunotherapy targeting CD4 + T cells with a view to providing assistance in the diagnosis and treatment of PD.

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Intragastric Administration of Casein Leads to Nigrostriatal Disease Progressed Accompanied with Persistent Nigrostriatal—Intestinal Inflammation Activited and Intestinal Microbiota—Metabolic Disorders Induced in MPTP Mouse Model of Parkinson’s Disease

Cited by 13 publications

References 111 publications

Differential Gut Microbiota Compositions Related With the Severity of Major Depressive Disorder

Differential Gut Microbiota Compositions Related With the Severity of Major Depressive Disorder

Gut Microbial Alteration in MPTP Mouse Model of Parkinson Disease is Administration Regimen Dependent

Differentiation and regulation of CD4+ T cell subsets in Parkinson’s disease

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