Intrahepatic biliary cystic neoplasms: Surgical results of 9 patients and literature review

Emre, Ali; Serin, Kürşat Rahmi; Özden, İlgin; Tekant, Yaman; Bilge, Orhan; Alper, Aydın; Güllüoğlu, Mine; Güven, Koray

doi:10.3748/wjg.v17.i3.361

Cited by 50 publications

(78 citation statements)

References 34 publications

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“…Biliary cysts usually do not require treatment unless symptomatic, while mucin-producing cystic neoplasms are treated with surgical resection (9). Thus, differentiation of these lesions is important.…”

Section: Discussionmentioning

confidence: 99%

A Hepatic Cyst Complicated by Hemorrhage with Secondary Revascularization Mimicking Mucin-Producing Cystic Neoplasm: Radiologic-Pathologic Correlations

2018

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Cystic hepatic lesions are commonly encountered in clinical practice. Most of them are simple hepatic cysts such as biliary cysts. However, complicated biliary cysts with hemorrhage, necrosis, and organization pose diagnostic challenges since imaging findings overlap with those of neoplastic cystic lesions. Here, we report a case of biliary cyst complicated by hemorrhage with secondary revascularization with ultrasound, computed tomography, and gadoxetic acid-enhanced magnetic resonance imaging findings mimicking mucin-producing cystic neoplasm.

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Section: Discussionmentioning

confidence: 99%

A Hepatic Cyst Complicated by Hemorrhage with Secondary Revascularization Mimicking Mucin-Producing Cystic Neoplasm: Radiologic-Pathologic Correlations

2018

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“…The necessity and utility of obtaining cyst fluid aspiration for tumor marker (CEA or CA19-9) measurements has been a controversial issue until recently. The CA19-9 level of cystic fluid has been proposed "as a diagnostic help in liver cysts of unknown nature", and some centers have incorporated cyst fluid tumor marker (CA19-9 and CEA) measurements into their management algorithm (Koffron et al, 2004;Emre et al, 2011). However, definite diagnostic criteria for CA19-9 and CEA levels have not yet been established because the published data are largely limited to reports on increased marker levels in small numbers of BCA patients, without statistically robust comparison with levels in simple cysts.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of biliary cystadenoma and cystadenocarcinoma of the liver

Chen

Liu

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) are rare biliary duct neoplasms. This study investigated reasonable management strategies of cystic neoplasms in the liver. Charts of 39 BCA/BCAC patients (9 males, 30 female; median age 53.74 ± 14.50 years) who underwent surgery from January 1999 to December 2009 were reviewed retrospectively. Cyst fluid samples of 32 BCA/BCAC patients and 40 simple hepatic cyst patients were examined for the tumor markers carbohydrate associated antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA). The most frequent symptoms were abdominal pain (N = 10), abdominal mass (N = 7), abdominal distension (N = 4), jaundice (N = 2), and fever (N = 3); the remaining patients showed no clinical symptoms. Liver resection (N = 17) or enucleation (N = 22) was performed in the 39 patients. Ultimately, 35 patients were diagnosed with intrahepatic BCA and four patients were diagnosed with BCAC. The median CA19-9 level was significantly higher in BCA/BCAC patients than in simple hepatic cyst patients. The median CEA levels in BCA/BCAC patients and controls were 6.83 ± 2.43 and 4.21 ± 2.91 mg/L, respectively. All symptoms were resolved after surgery, and only one BCAC patient showed recurrence. The incidence of intrahepatic cystic lesions was 1.7%. Increased CA19-9 levels in the cyst fluid is a helpful marker for distinguishing BCA/BCAC from common simple cysts. The presence of coarse calcifications is suggestive of BCAC. Complete surgical removal of these lesions yielded satisfying long-term outcomes with a very low recurrence rate.

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“…The histological type of lesion involved represents the crucial factor for determining the correct surgical method to be applied. If malignancy is suspected, radical removal of the cyst should be performed, if possible, i.e., radical liver resection (14,15). Enucleation is possible and sufficient in cystadenomas with low-grade intraepithelial neoplasia.…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic biliary cystadenoma—diagnosis and treatment options

Třeška

Ferda²,

Daum³

et al. 2016

Turk J Gastroenterol

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Intrahepatic biliary cystic neoplasms: Surgical results of 9 patients and literature review

Abstract: In spite of the improvement in imaging modalities and increasing recognition of biliary cystadenoma and cystadenocarcinoma, accurate preoperative diagnosis may be difficult. Complete surgical removal (liver resection or enucleation) of these lesions yields satisfying long-term results.

Cited by 50 publications

References 34 publications

A Hepatic Cyst Complicated by Hemorrhage with Secondary Revascularization Mimicking Mucin-Producing Cystic Neoplasm: Radiologic-Pathologic Correlations

A Hepatic Cyst Complicated by Hemorrhage with Secondary Revascularization Mimicking Mucin-Producing Cystic Neoplasm: Radiologic-Pathologic Correlations

Surgical management of biliary cystadenoma and cystadenocarcinoma of the liver

Intrahepatic biliary cystadenoma—diagnosis and treatment options

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