Intrahepatic cholangiocarcinoma in cirrhosis presents granulocyte and granulocyte-macrophage colony-stimulating factor

Sasaki, Motoko; Tsuneyama, Koichi; Ishikawa, Akira; Nakanuma, Yasuni

doi:10.1016/j.humpath.2003.07.012

Cited by 49 publications

(51 citation statements)

References 27 publications

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“…An elevated systemic neutrophil count may also correlate with neutrophilic infiltration of the tumour. Sasaki et al [46] demonstrated that prominent neutrophilic infiltration was frequently observed in IHCC with cirrhosis and this was thought to be related to neutrophil infiltration-related cytokines such as interleukin 8, granulocyte colonystimulating factor and granulocyte macrophage colony-stimulating factor. The expression of these cytokines was frequently associated with poorer outcome as observed in pulmonary adenocarcinoma [47,48].…”

Section: Journal Of Surgical Oncologymentioning

confidence: 99%

Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma

Gomez

Morris‐Stiff

Toogood

et al. 2008

Journal of Surgical Oncology

154

130

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Section: Journal Of Surgical Oncologymentioning

confidence: 99%

Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma

Gomez

Morris‐Stiff

Toogood

et al. 2008

Journal of Surgical Oncology

154

130

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“…A search of PubMed by the key words CSF and biliary cancer, revealed three and five reports, respectively, of intrahepatic cholangiocarcinoma and gallbladder carcinoma [3][4][5][6][7][8][9][10] , but there have so far been no reports of extrahepatic bile duct malignancy. While two of these patients underwent curative surgery and survived without recurrence for 18 mo and 27 mo, respectively [6,8] , three patients died within 6 mo after palliative or exploratory surgery [3,5,9] .…”

Section: Discussionmentioning

confidence: 99%

“…While two of these patients underwent curative surgery and survived without recurrence for 18 mo and 27 mo, respectively [6,8] , three patients died within 6 mo after palliative or exploratory surgery [3,5,9] . In one case, the details of the surgery were unknown [4] , and the other was a report of archival histological examination [7] . In a case of rapid progression, the patient died 5 d after admission [10] .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, patients with G-CSF-producing cancer generally have a poor prognosis, and early diagnosis and treatment are required. Biliary cancer, such as cholangiocellular and gallbladder carcinoma are reported to produce G-CSF in some cases [3][4][5][6][7][8][9][10] , however, extrahepatic bile duct cancer that produces G-CSF has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

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An autopsy case of granulocyte-colony-stimulating-factor-producing extrahepatic bile duct carcinoma

Matsuyama¹,

Shimonishi²,

Yoshimura³

et al. 2008

WJG

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A 79-year-old man was referred to this department due to the presence of extrahepatic bile duct carcinoma with a tumor at the left chest wall. The lesion was suspected to be a metastasis of bile duct carcinoma to the left wall, however, computed tomography (CT) revealed no regional lymph node or liver metastases. In addition, cytological and pathological examinations did not show malignancy. At the time of admission, the white blood cell count was 21 460 cells/μL (neutrophils, 18 240 cells/μL) and this elevated to 106 040 before death. In addition, serum granulocyte colony-stimulating factor (G-CSF) was elevated. At 28 d after admission, the patient died. An autopsy showed a poorly differentiated adenocarcinoma with sarcomatous change, which had slightly invaded into the pancreas around the bile duct, and was found in the distal bile duct with multiple metastases to the chest wall, lung, kidney, adrenal body, liver, mesentery, vertebra and mediastinal and para-aortic lymph nodes, without locoregional lymph node and liver metastasis. The cancer cells showed positive immunohistochemical staining for anti-G-CSF antibody. This is believed to be the first report of an extrahepatic bile duct carcinoma that produces G-CSF. Since G-CSF-producing carcinoma and sarcomatous change of the biliary tract leads to poor prognosis, early diagnosis and treatment are needed. When infection is ruled out, the G-CSF in serum should be examined. In addition, examinations such as bone scintigraphy and chest CT should also be considered for distant metastasis. Matsuyama S, Shimonishi T, Yoshimura H, Higaki K, Nasu K, Toyooka M, Aoki S, Watanabe K, Sugihara H. An autopsy case of granulocyte-colony-stimulating-factor-producing extrahepatic bile duct carcinoma.

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“…However, granulocyte-colony-stimulating factor (G-CSF) was reported to be produced by tumor cells in many cases of CCC, suggesting that the tumor occasionally has a potential for paraneoplastic leukocytosis. 3 We experienced a case of CCC presenting with both leukocytosis and hypercalemia. Because the present case of CCC accompanied by paraneoplastic syndrome is very rare, we report our immunohistochemical investigations of the production of both G-CSF and parathyroid hormonerelated protein (PTH-rP) by the tumor.…”

mentioning

confidence: 99%

Cholangiocellular carcinoma that produced both granulocyte-colony-stimulating factor and parathyroid hormone-related protein

et al. 2006

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A 56-year-old man was admitted to our hospital because of consciousness disturbance. Abdominal computed tomography revealed a large low-density tumor in the left lobe of the liver. He presented with marked leukocytosis and hypercalcemia with high levels of serum granulocyte-colony-stimulating factor (G-CSF) and parathyroid hormone-related protein (PTH-rP). A diagnosis of cholangiocellular carcinoma (CCC) of the liver was confirmed by histological examination of an autopsy specimen. The tumor cells showed positivity for both G-CSF and PTH-rP with immunohistochemical staining. These results suggest that the tumor was producing both G-CSF and PTH-rP. This paraneoplastic G-CSF and PTH-rP production caused by CCC is very rare. Such cases must be followed up carefully, since tumors associated with paraneoplastic syndrome progress rapidly, resulting in a poor prognosis.

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Intrahepatic cholangiocarcinoma in cirrhosis presents granulocyte and granulocyte-macrophage colony-stimulating factor

Cited by 49 publications

References 27 publications

Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma

Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma

An autopsy case of granulocyte-colony-stimulating-factor-producing extrahepatic bile duct carcinoma

Cholangiocellular carcinoma that produced both granulocyte-colony-stimulating factor and parathyroid hormone-related protein

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