Intrahepatic cholangiocarcinoma is more complex than we thought: A case report

Abstract

BACKGROUND Brain metastasis from intrahepatic cholangiocarcinoma is rare. To the best of our knowledge, only a few cases have been reported. The biological behavior was complex, and treatment requires further investigation. CASE SUMMARY A 62-year-old woman complained of left limb weakness. Abdominal computed tomography showed a 5.0 cm × 5.6 cm lesion in the left lobe of the liver. Tumor markers were normal. Serological analysis indicated absence of hepatitis virus. Brain magnetic resonance imaging revealed a 1.0 cm × 1.3 cm mass in the right frontal lobe. Intrahepatic cholangiocarcinoma with brain metastasis was diagnosed by our liver cancer multidisciplinary team. After sufficient preparation, the patient underwent partial frontal lobotomy and left hemihepatectomy. Histopathological results confirmed that both the lesions were cholangiocarcinoma. Six cycles of gemcitabine combined with S1 were administered. During a 39 mo postoperative follow-up, no sign of local recurrence or distant metastasis was observed. CONCLUSION This case expands our knowledge concerning the complex and heterogeneous nature of tumor metastasis.

Case report: immunotherapy successfully treated brain metastasis in intrahepatic cholangiocarcinoma and literature review

“…Solid central nervous system (CNS) metastasis from iCCA is rare, and together with this case, there are currently only 20 cases having been reported in literature ( Table 1 ) ( 40 – 48 ). The ages of these patients range from 46 to 75 (mean 61.1 years), and the male: female ratio is 1:1.9.…”

“…Compared with the invasive surgical resection strategy, our MDT considered PD1 inhibitor plus targeted drug combination therapy might be the best choice. Solid central nervous system (CNS) metastasis from iCCA is rare, and together with this case, there are currently only 20 cases having been reported in literature (Table 1) (40)(41)(42)(43)(44)(45)(46)(47)(48). The ages of these patients range from 46 to 75 (mean 61.1 years), and the male: female ratio is 1:1.9.…”