Intrahepatic cholangiocarcinoma: MR appearance.

Hamrick-Turner, Jennifer E.; Abbitt, Patricia L.; Ros, Pablo R.

doi:10.2214/ajr.158.1.1309221

Cited by 68 publications

(46 citation statements)

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“…Of course, this will not occur with US contrast agents that are pure intravascular tracers. [27][28][29][30][31][32] The results of this study raise major concerns about the use of CEUS as the only dynamic imaging technique for noninvasive diagnosis. To our knowledge, the only study that has prospectively evaluated the diagnostic accuracy of CEUS for HCC diagnosis showed that CEUS misclassified a 16-mm ICC as HCC.…”

Section: Discussionmentioning

confidence: 98%

Intrahepatic Peripheral Cholangiocarcinoma in Cirrhosis Patients May Display A Vascular Pattern Similar to Hepatocellular Carcinoma on Contrast-Enhanced Ultrasound

et al. 2010

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The aim of this study was to describe the imaging features by contrast-enhanced ultrasound (CEUS) of intrahepatic cholangiocarcinoma (ICC) in cirrhosis patients. We registered the CEUS images of cirrhosis patients with histologically confirmed ICC. In all cases magnetic resonance imaging (MRI) was done to confirm the diagnosis and/or staging purposes. A total of 21 patients met all the criteria to be included in the study. The median nodule size was 32 mm. All nodules showed contrast enhancement at arterial phase; in 10 cases it was homogeneous and in 11 cases peripheral (rim-like). All nodules displayed washout during the venous phases; it appeared during the first 60 seconds in 10 nodules, between 60-120 seconds in five cases, and in six cases after 2 minutes. Ten nodules (five larger than 2 cm) displayed homogeneous contrast uptake followed by washout and they correspond to the specific pattern of hepatocellular carcinoma according to the American Association for the Study of Liver Diseases criteria. However, none of these lesions displayed washout on MRI. Conclusion : CEUS should not be used as the sole imaging technique for conclusive hepatocellular carcinoma diagnosis and if the MRI does not display the diagnostic vascular pattern, a confirmatory biopsy is mandatory. Hepatology 2010;51:2020–2029

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Section: Discussionmentioning

confidence: 98%

Intrahepatic Peripheral Cholangiocarcinoma in Cirrhosis Patients May Display A Vascular Pattern Similar to Hepatocellular Carcinoma on Contrast-Enhanced Ultrasound

et al. 2010

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“…CT characteristics of this tumor are an irregular large mass with very low attenuation, slight contrast enhancement usually at the periphery, and focal intrahepatic bile ductal dilatation around the tumor [ 1 -3 , 6]. M R I characteristics of this tumor are an irregular large mass with low intensity on T l -w e i g h t e d images and high intensity on T2-weighted images, and minimal to moderate rim enhancement of the tumors [7,8]. On dynamic CT, the tumor shows low attenuation in the early phase and has increased CT numbers in delayed phase [6].…”

Section: Discussionmentioning

confidence: 99%

“…On dynamic MRI, the tumor shows progressive and concentric filling with contrast material [9]. This characteristic enhancement pattern may depend on a large amount of fibrous tissue and neovasculavity in the tumors [8,9]. The mechanism of prolonged enhancement of fibrous tumors has not been clarified, but the slow washout of extravascular contrast agents in fibrous stroma may play a major role [10].…”

Section: Discussionmentioning

confidence: 99%

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Peripheral cholangiocarcinoma: comparison of MRI with CT

et al. 1995

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To evaluate the clinical utility of computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis of peripheral cholangiocarcinoma of the liver, 11 patients with pathologically proven peripheral cholangiocarcinoma were examined with both CT and MRI. On CT scans in 10 cases, the tumors appeared as irregular, low-attenuation masses with a wide variation in heterogeneity. Contrast enhancement of the tumors was mild in nine cases and moderate in one case, at the periphery. Tumor was not identified in one case. On T1-weighted MRIs, the tumors showed low intensity in eight cases and isointensity in three cases. On T2-weighted images, the tumors showed high intensity in all 11 cases. Focal dilatation of the intrahepatic bile ducts around the tumor was seen in one case on MRIs and in four cases on CT scans. Portal vein invasion of the tumors was seen in one case, and lymphadenopathy was seen in four cases on both MRIs and CT scans. MRI was slightly superior to CT in detecting the tumors, was inferior to CT in delineating focal ductal dilatation around the tumors, and was equal to CT in assessing extent of the tumors.

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“…Intrahepatic cholangiocarcinoma is a relatively uncommon tumor that arises from the intrahepatic bile ducts, and represents less than 10% of primary hepatic tumors. Although the computed tomographic (CT) features of intrahepatic cholangiocarcinomas have been well described [2][3][4], their appearances on magnetic resonance (MR) images have received little attention [5][6][7]. In this retrospective analysis, we studied the MR imaging features of seven cases of pathologically proven intrahepatic cholangiocarcinoma.…”

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confidence: 99%