Intrahepatic Cholangiocarcinoma: MRI and Pathologic Correlation in 14 Patients

Vilgrain,; Beers, Bernard E. Van; Flejou, JF; Belghiti, Jacques; Delos, Monique; Gautier, AL; Zins, Marc; Denys, Alban; Menu, Y.

doi:10.1097/00004728-199701000-00012

Cited by 77 publications

(52 citation statements)

References 16 publications

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“…However, other hepatic tumors, such as hepatocellular carcinoma and metastases, can be accompanied by satellite nodules. IMCs have been described as either homogeneous or heterogeneous, low-intermediate in signal intensity on T1-weighted images, and intermediate-mildly high in signal on T2-weighted images [11,22] which is in agreement with our findings. Though these features were typical, they were nonspecific.…”

Section: Discussionsupporting

confidence: 93%

“…In the literature, some reports have described MRI of IMC [10,11] but, to the best of our knowledge, there are few studies with descriptions of Gd-BOPTA MRI features relating to mass-forming cholangiocarcinoma, and in particular only one large and extensive study of the hepatobiliary pattern has been published [4]. Though some suggestive features have been reported, IMC is often difficult to differentiate from metastatic adenocarcinoma [12].…”

Section: Discussionmentioning

confidence: 99%

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Intrahepatic mass-forming cholangiocarcinoma: enhancement pattern on Gd-BOPTA-MRI with emphasis of hepatobiliary phase

et al. 2015

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Gd-BOPTA MRI pattern of IMC on dynamic study is similar to that of conventional extracellular agents, that is peripheral enhancement with progressive and concentric filling of contrast material on delayed phases. At 10-15 min delayed phases, IMC shows often a peripheral hypointense rim consistent with a target appearance. In the HBP, due to progressive central enhancement (cloud) and peripheral hypointense rim, an higher number of tumors show a target appearance; this pattern is not specific and would also be expected to be seen in metastases from adenocarcinoma.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Intrahepatic mass-forming cholangiocarcinoma: enhancement pattern on Gd-BOPTA-MRI with emphasis of hepatobiliary phase

et al. 2015

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“…Usually tumors greater than 3 cm in size are hyperechoic, while smaller tumors are iso-to hypoechoic (36). A hypoechoic halo, visible in about 15% of tumors, represents a rim of proliferating tumor cells with compressed adjacent liver parenchyma (36).…”

Section: Usmentioning

confidence: 99%

Multimodality imaging of intrahepatic cholangiocarcinoma

Fábrega-Foster¹,

Ghasabeh²,

Pawlik³

et al. 2017

Hepatobiliary Surg. Nutr.

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Intrahepatic cholangiocarcinomas account for approximately 20% of cases of cholangiocarcinomas.Three growth patterns or morphologic subtypes exist, including mass-forming, periductal-infiltrating, and intraductal-growth subtypes. Knowledge of these morphologic subtypes and their radiologic appearance aids in timely diagnosis, a key to optimizing patient outcomes. The morphologic variability of intrahepatic cholangiocarcinomas has a direct impact on the diagnostic sensitivity and specificity of various diagnostic imaging modalities, including ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI)/magnetic resonance cholangiopancreatography (MRCP), and positron emission tomography (PET).The following review emphasizes optimal imaging technique for each of these modalities and reviews the imaging appearance of each morphologic subtype of intrahepatic cholangiocarcinoma.

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“…Mass-forming CC are often seen in iCC and usually appear as T1 iso- or hypointense as well as T2 hyperintense [56]. Contrast enhancement of mass-forming iCC is variable.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Imaging of Cholangiocarcinoma

Olthof¹,

Othman²,

Clasen³

et al. 2016

Visc Med

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Cholangiocarcinoma (CC) is the second most common primary hepatobiliary tumour, and it is increasing in incidence. Imaging characteristics, behaviour, and therapeutic strategies in CC differ significantly, depending on the morphology and location of the tumour. In cross-sectional imaging, CCs can be classified according to the growth pattern (mass-forming, periductal infiltrating, intraductal) and the location (intrahepatic, perihilar, extrahepatic/distal). The prognosis of CC is unfavourable and surgical resection is the only curative treatment option; thus, early diagnosis (also in recurrent disease) and accurate staging including the evaluation of lymph node involvement and vascular infiltration is crucial. However, the diagnostic evaluation of CC is challenging due to the heterogeneous nature of the tumour. Diagnostic modalities used in the imaging of CC include transabdominal ultrasound, endosonography, computed tomography, magnetic resonance imaging with cholangiopancreatography, and hybrid imaging such as positron emission tomography/computed tomography. In this review, the potential of cross-sectional imaging modalities in primary staging, treatment monitoring, and detection of recurrent disease will be discussed.

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Intrahepatic Cholangiocarcinoma: MRI and Pathologic Correlation in 14 Patients

Abstract: Our study suggests that the MR features of intrahepatic cholangiocarcinoma are well correlated with pathologic findings, but are nonspecific. Associated findings may strengthen the diagnosis of intrahepatic cholangiocarcinoma at MRI.

Cited by 77 publications

References 16 publications

Intrahepatic mass-forming cholangiocarcinoma: enhancement pattern on Gd-BOPTA-MRI with emphasis of hepatobiliary phase

Intrahepatic mass-forming cholangiocarcinoma: enhancement pattern on Gd-BOPTA-MRI with emphasis of hepatobiliary phase

Multimodality imaging of intrahepatic cholangiocarcinoma

Imaging of Cholangiocarcinoma

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