Intrahepatic cholangiocarcinoma with intrahepatic biliary lithiasis arising 47 years after the excision of a congenital biliary dilatation: Report of a case

Yamashita, Satoshi; Arita, Junichi; Sasaki, Takashi; Kaneko, Junichi; Aoki, Taku; Beck, Y; Sugawara, Yasuhiko; Hasegawa, Kiyoshi; Kokudo, Norihiro

doi:10.5582/bst.2012.v6.2.98

Cited by 6 publications

(3 citation statements)

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“…Heightened amounts of proinflammatory cytokines and signaling components in patients with malignancies for one aspect might mirror disease activity and body's natural response to the tumor [ 20 ], for another aspect would facilitate the formation of new blood vessels and lymphatic vessels [ 14 , 21 ]. In particular, BTC development and progression have been reported to be closely mediated by chronic biliary inflammation caused by gallstones, chronic hepatitis, etc [ 22 – 25 ]. Thus, inflammatory markers might possibly be used as valuable prognostic predictors for BTC patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of neutrophil-to-lymphocyte ratio in biliary tract cancers: a systematic review and meta-analysis

Tang

Lü

Li³

et al. 2017

Oncotarget

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BackgroundInflammation was considered to perform crucial roles in the development and metastasis of malignancies. A heightened neutrophil-lymphocyte ratio has been described to be associated with detrimental survivals in different malignancies. Debate remains over the impact of heightened neutrophil-lymphocyte ratio on survivals in biliary tract cancer. The review evaluated the prognostic value of neutrophil-lymphocyte ratio in biliary tract cancer.MethodsMEDLINE, the Cochrane Library, EMBASE, and the Chinese SinoMed were systematically searched for relevant articles. Associations between neutrophil-lymphocyte ratio and long-term outcomes were expressed as the hazard ratios and 95% confidence intervals. The odds ratio was utilized to assess the association between neutrophil-lymphocyte ratio and clinicopathological parameters.ResultsFourteen studies consisting of 3217 patients were analyzed: 1278 (39.73%) in the high pretreatment neutrophil-lymphocyte ratio group and 1939 (60.27%) in the low pretreatment neutrophil-lymphocyte ratio one. The results proved that heightened pretreatment neutrophil-lymphocyte ratio was significantly associated with detrimental overall survival and relapse free survival for biliary tract cancer patients. In addition, elevated neutrophil-lymphocyte ratio was positively correlated with higher carbohydrate antigen 19-9 levels, advanced TNM staging and greater lymph node involvement.ConclusionThis meta-analysis marked that an increased pretreatment neutrophil-lymphocyte ratio was significantly linked with detrimental long-term outcomes and clinicopathological parameters for patients with biliary tract cancer.

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Section: Introductionmentioning

confidence: 99%

Prognostic significance of neutrophil-to-lymphocyte ratio in biliary tract cancers: a systematic review and meta-analysis

Tang

Lü

Li³

et al. 2017

Oncotarget

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“…The incidence and mortality of ICC have been increasing worldwide over the past 30 years, while the incidence of all other forms of cholangiocarcinoma has been declining slightly (5)(6)(7)(8)(9)(10)(11). Thus far, several risk factors for ICC have been identified, including liver fluke infection, primary sclerosing cholangitis, and hepatolithiasis; hepatolithiasis has been found to be etiologically related to the development of ICC (12)(13)(14)(15)(16)(17). Surgery is the main form of treatment and it offers the hope of prolonged survival for patients with ICC.…”

Section: Introductionmentioning

confidence: 99%

The expression and clinicopathological role of CDX2 in intrahepatic cholangiocarcinoma

Tang

Wang

Wen-ping

et al. 2018

IRDR

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The aim of this study was to examine the expression and clinicopathological role of caudal homeobox 2 (CDX2) in intrahepatic cholangiocarcinoma (ICC). CDX2 expression was determined immunohistochemically in 93 patients with ICC. The association between CDX2 expression and clinicopathological features of ICC was also examined in patients with ICC. Immunohistochemical staining for CDX2 was noted in 27 patients (29.03%); patients with CDX2-positive tumors had significant survival advantages over those with CDX2- negative tumors (median survival was 40 months for patients with CDX2-positive tumors and 13 months for patients with CDX2-negative tumors; the hazard ratio was 0.36, the 95% confidence interval was 0.22-0.59, and < 0.001). The rate of CDX2 expression was 13.46% in patients with lymphatic invasion and 48.78% in patients without lymphatic invasion ( = 13.88, < 0.01); positivity for CDX2 expression was significantly higher in patients with well-differentiated or moderately differentiated tumors than that in patients with poorly differentiated tumors (41.7% in patients with well-differentiated tumors, 47.6% in patients with moderately differentiated tumors, and 20.0% in patients with poorly differentiated tumors; Mann-Whitney test, = 0.01). In addition, CDX2 expression differed significantly in patients with ICC due to hepatolithiasis and patients with ICC not due to hepatolithiasis (36.51% and 13.33%, respectively, = 5.30, = 0.02). Positivity for CDX2 expression resulted in significant survival advantages for patients with ICC. CDX2 might be used as a prognostic marker in patients with ICC.

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“…Some patients with congenital biliary dilatation (CBD) have developed hepatolithiasis long after primary excision of the choledochal cyst , and most prefer non‐surgical treatment, such as PTCS, but its long‐term outcome after stone removal remains unclear. Furthermore, the relative risks of biliary tract cancer in those patients are high, even after excision of the choledochal cyst .…”

Section: Introductionmentioning

confidence: 99%

Ten‐year long‐term results after non‐surgical management of hepatolithiasis, including cases with choledochoenterostomy

Tsuyuguchi

Miyakawa

Sugiyama

et al. 2014

J Hepato Biliary Pancreat

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Intrahepatic cholangiocarcinoma with intrahepatic biliary lithiasis arising 47 years after the excision of a congenital biliary dilatation: Report of a case

Cited by 6 publications

References 20 publications

Prognostic significance of neutrophil-to-lymphocyte ratio in biliary tract cancers: a systematic review and meta-analysis

Prognostic significance of neutrophil-to-lymphocyte ratio in biliary tract cancers: a systematic review and meta-analysis

The expression and clinicopathological role of CDX2 in intrahepatic cholangiocarcinoma

Ten‐year long‐term results after non‐surgical management of hepatolithiasis, including cases with choledochoenterostomy

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