Intrahepatic cholestasis of pregnancy and theory of inheritance of the disease. Literature review

Niemyjska-Dmoch, Weronika; Kosiński, Przemysław; Węgrzyn, Piotr; Luterek, Katarzyna; Jezela-Stanek, Aleksandra

doi:10.1080/14767058.2023.2279020

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…The liver is a target organ for toxic reactions to drugs and their metabolites and is also the main site of estrogen metabolism . Cholestasis hepatic injury (CHI) is a common clinical feature of a group of diseases caused by bile flow disorders and is often associated with abnormal estrogen levels in vivo . , The probability of CHI is generally higher in women than in men, and numerous scholars have suggested that abnormal estrogen levels are an important reason. − …”

Section: Introductionmentioning

confidence: 99%

Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2

Chen,

Qian,

et al. 2024

Chem. Res. Toxicol.

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With the increasing use of oral contraceptives and estrogen replacement therapy, the incidence of estrogen-induced cholestasis (EC) has tended to rise. Psoralen (P) and isopsoralen (IP) are the major bioactive components in Psoraleae Fructus, and their estrogen-like activities have already been recognized. Recent studies have also reported that ERK1/2 plays a critical role in EC in mice. This study aimed to investigate whether P and IP induce EC and reveal specific mechanisms. It was found that P and IP increased the expression of esr1, cyp19a1b and the levels of E2 and VTG at 80 μM in zebrafish larvae. Exemestane (Exe), an aromatase antagonist, blocked estrogen-like activities of P and IP. At the same time, P and IP induced cholestatic hepatotoxicity in zebrafish larvae with increasing liver fluorescence areas and bile flow inhibition rates. Further mechanistic analysis revealed that P and IP significantly decreased the expression of bile acids (BAs) synthesis genes cyp7a1 and cyp8b1, BAs transport genes abcb11b and slc10a1, and BAs receptor genes nr1h4 and nr0b2a. In addition, P and IP caused EC by increasing the level of phosphorylation of ERK1/2. The ERK1/2 antagonists GDC0994 and Exe both showed significant rescue effects in terms of cholestatic liver injury. In conclusion, we comprehensively studied the specific mechanisms of P- and IP-induced EC and speculated that ERK1/2 may represent an important therapeutic target for EC induced by phytoestrogens.

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Section: Introductionmentioning

confidence: 99%

Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2

Chen,

Qian,

et al. 2024

Chem. Res. Toxicol.

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Intrahepatic cholestasis in the third pregnancy: A case report

Guo,

Zhang,

et al. 2025

Asian Journal of Surgery

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Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization

Zhu,

Xu,

Beejadhursing

et al. 2024

BMC Pregnancy Childbirth

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Background Intrahepatic cholestasis of pregnancy (ICP) is an idiopathic disease of pregnancy. Little is known about how it specifically affects pregnancies resulting from in vitro fertilization (IVF). Our aim is to evaluate the impact of IVF on the perinatal outcomes of ICP. Methods A retrospective study of 242 patients with intrahepatic cholestasis of pregnancy, comprising 36 conceived through IVF and 206 spontaneous conceptions (SC), enrolled between 2019 and 2021 was carried out. Data were analyzed from the medical archives of the Huazhong University of Science and Technology, Tongji Hospital. Results Numerical values of transaminases (ALT, alanine aminotransferase; AST, aspartate aminotransferase) and serum total bile acid (TBA) are significantly lower in the IVF group than that in the spontaneous conceived group (p < 0.05). The incidence of gestational diabetes mellitus (GDM) was higher in the IVF group than in SC group (30.6% vs. 16%, p = 0.037). The cesarean section (CS) rates are higher in the IVF group (97.2% vs. 85.4%, p = 0.023). On the other hand, the prevalence of premature rupture of membranes (PROM) was higher in the SC group (10.7%) while none was reported in the IVF-ICP group. Other maternal comorbidities and neonatal outcomes were similar between the two groups. Conclusion ICP patients who underwent IVF are more likely to suffer from GDM. Therefore, monitoring and management of blood glucose should be strengthened during pregnancy. Fortunately, IVF does not seem to worsen the progression or outlook of ICP, so sticking to standard management practices is recommended.

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Intrahepatic cholestasis of pregnancy and theory of inheritance of the disease. Literature review

Cited by 3 publications

References 54 publications

Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2

Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2

Intrahepatic cholestasis in the third pregnancy: A case report

Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization

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