Intrahepatic Cholestasis of Pregnancy Complicated by COVID-19 Infection [ID: 1381429]

Abstract

INTRODUCTION: Type 1 diabetes mellitus (T1DM) during pregnancy is associated with increased risk of maternal and fetal complications. We aimed to compare the risk of adverse perinatal outcomes in women with pregestational T1DM to those of background population. METHODS:In this historical cohort study, we included Mexican pregnant women who attended from 2016 to 2021 a tertiary-level hospital in Mexico City. Group 1: Pregnant women with T1DM; group 2: pregnant women without diabetes, matched 1:2 by maternal age, pregestational body mass index (BMI), gestational age at admission and parity with women of group 1. Relative risk (RR) with a 95% CI was calculated using logistic regression. We had IRB approval.RESULTS: Group 1, n5203; group 2, n5406; there were no differences in maternal age, pregestational BMI, gestational age, and parity. The mean glycated hemoglobin A 1C and gestational age at admission to prenatal care in T1DM women were 8.062.0 and 19.166.6, respectively. The risk of adverse perinatal outcomes was increased in women with T1DM and were expressed as RR (95% IC); preterm birth, 4.03 (3.0-5.3);