Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes

Martineau, Marcus; Raker, Christina; Powrie, Raymond; Williamson, Catherine

doi:10.1016/j.ejogrb.2013.12.037

Cited by 125 publications

(115 citation statements)

References 33 publications

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“…This association was lost in women treated with UDCA. The findings of this prospective study support the observations made by ourselves and others that ICP is associated with increased rates of GDM (13,14,17) and characterized by elevated serum levels of glucose (20), triglycerides, and total and LDL cholesterol, as well as a fall in HDL cholesterol (15,16,25).…”

Section: Resultssupporting

confidence: 90%

“…An association between glucose intolerance and dyslipidemia in ICP has previously been reported (5,(13)(14)(15)(16), with a recent retrospective study reporting an increased incidence of gestational diabetes mellitus (GDM) following the onset of cholestasis, suggesting that this may be the result of aberrant bile acid homeostasis (17).…”

mentioning

confidence: 92%

“…There is also now increasing evidence to suggest accelerated fetal growth in pregnancy complicated by ICP (17) with reports of infants who are large for gestational age at birth (4,14). Although unconfirmed, it is possible that this may contribute to the metabolic changes reported in the adolescent offspring of cholestatic pregnancies (19).…”

mentioning

confidence: 99%

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The Metabolic Profile of Intrahepatic Cholestasis of Pregnancy Is Associated With Impaired Glucose Tolerance, Dyslipidemia, and Increased Fetal Growth

et al. 2014

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OBJECTIVEQuantification of changes in glucose and lipid concentrations in women with intrahepatic cholestasis of pregnancy (ICP) and uncomplicated pregnancy and study of their influence on fetal growth. RESEARCH DESIGN AND METHODSA prospective study comparing metabolic outcomes in cholestastic and uncomplicated singleton pregnancies was undertaken at two university hospitals in the U.K. and U.S. from 2011-2014. A total of 26 women with ICP and 27 control pregnancies with no prior history of gestational diabetes mellitus were recruited from outpatient antenatal services and followed until delivery. Alterations in glucose, incretins, cholesterol, and triglycerides were studied using a continuous glucose monitoring (CGM) system and/or a standard glucose tolerance test (GTT) in conjunction with GLP-1 and a fasting lipid profile. Fetal growth was quantified using adjusted birth centiles. RESULTSMaternal blood glucose concentrations were significantly increased in ICP during ambulatory CGM (P < 0.005) and following a GTT (P < 0.005). ICP is characterized by increased fasting triglycerides (P < 0.005) and reduced HDL cholesterol (P < 0.005), similar to changes observed in metabolic syndrome. The offspring of mothers with ICP had significantly larger customized birth weight centiles, adjusted for ethnicity, sex, and gestational age (P < 0.005). CONCLUSIONSICP is associated with impaired glucose tolerance, dyslipidemia, and increased fetal growth. These findings may have implications regarding the future health of affected offspring.

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Section: Resultssupporting

confidence: 90%

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confidence: 92%

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The Metabolic Profile of Intrahepatic Cholestasis of Pregnancy Is Associated With Impaired Glucose Tolerance, Dyslipidemia, and Increased Fetal Growth

et al. 2014

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“…59 Literatürde, GİK tanısı alan kadınların gestasyonel diyabet olma riskinin arttığı yönünde rapor edilmiş çalışmalar mevcuttur. 64,65 Ancak bu durumun ortaya çıkarılması veya dışlanması için daha fazla çalışmaya ihtiyaç vardır. Birkaç çalışmada, GİK ve preeklampsi arasındaki ilişki bildirilmiştir.…”

Section: Maternal Sonuçlarunclassified

Gestational Intrahepatic Cholestasis: Etiology, Maternal Outcome, Fetal Outcome and Management: Review

Abide¹,

Vural²

2017

Turkiye Klinikleri J Gynecol Obst

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“…We read with interest the paper by Martineau and colleagues on intrahepatic cholestasis of pregnancy (ICP) published online on January 7 2014 (1). We have also investigated pregnancy outcomes for women with ICP among 975,240 maternities in New South Wales (NSW), Australia.…”

Section: Dear Editormentioning

confidence: 99%

Intrahepatic cholestasis of pregnancy is not associated with stillbirth in an Australian maternity population

Bannister-Tyrrell

Ford

Morris

et al. 2014

European Journal of Obstetrics & Gynecology and Reproductiv

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Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes

Cited by 125 publications

References 33 publications

The Metabolic Profile of Intrahepatic Cholestasis of Pregnancy Is Associated With Impaired Glucose Tolerance, Dyslipidemia, and Increased Fetal Growth

The Metabolic Profile of Intrahepatic Cholestasis of Pregnancy Is Associated With Impaired Glucose Tolerance, Dyslipidemia, and Increased Fetal Growth

Gestational Intrahepatic Cholestasis: Etiology, Maternal Outcome, Fetal Outcome and Management: Review

Intrahepatic cholestasis of pregnancy is not associated with stillbirth in an Australian maternity population

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