Intrahepatic clear cell cholangiocarcinoma - An uncommon histologic subtype: case report and literature review

Baldaia, Cilénia; Tortosa, Francisco; Ramalho, F.

doi:10.17235/reed.2017.4239/2016

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…Immunohistochemical analysis would play an important role in distinguishing between clear cell HCC and other types. Positivity for CK7 and the absence of CK20 staining are considered features of cholangiocarcinoma [ 4 , 5 ]. It has been reported that CD56 positivity relates to the clear cell change [ 3 , 9 ], while ICC shows negativity for vimentin and CD56 [ 3 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery

et al. 2020

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Background Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy of primary liver cancer. Among the several pathological types of ICC, only five cases of the clear cell type have been reported, including the one presented below. Here we report a unique case of clear cell type ICC following laparoscopic hepatectomy. Case presentation A 67-year-old woman had a history of hepatitis B virus. Computed tomography revealed a ring-like enhanced mass 35 mm in diameter at segment 7 in the early phase. The enhancement was prolonged to the late phase through the portal phase, while the shape was irregular. Ethoxybenzy magnetic resonance imaging revealed that the tumor had a low signal intensity on T1-weighted imaging and a high signal intensity on T2-weighted imaging. Diffusion-weighted images identified that the tumor had remarkably high signal intensity. Tumor enhancement was not detected throughout the tumor in the hepatocyte phase. Upon ICC diagnosis, a laparoscopic S7 subsegmentectomy was performed. The patient’s postoperative course was uneventful. An immunohistochemical examination revealed that the cells tested positive for cytokeratin 7 (CK7), CK19, and CD56 and negative for CK20, CD10, α-fetoprotein, thyroid transcription factor-1. At 2 years after surgery, the patient remains alive without recurrence. Conclusions Here we presented a case of clear cell ICC that was treated by laparoscopic hepatectomy. Immunological analysis, especially by CD56 and several CK markers, is helpful for diagnosing this disease.

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Section: Discussionmentioning

confidence: 99%

Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery

et al. 2020

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“…Clear cell cholangiocarinomas are rare. Review of the literature, in the English language, revealed 11 cases of clear cell intrahepatic cholangiocarcinoma 7 8. and only four cases of perihilar clear cell cholangiocarcinoma 9 10…”

Section: Discussionmentioning

confidence: 99%

Perihilar clear cell cholangiocarcinoma: an often-diagnostic challenge

2020

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Cholangiocarcinomas are rare and often diagnosed late. Clear cell histology is a rare variant of such cancers. We report one such case of a man in his late 60s, with a history of excess alcohol intake, who was found to have deranged liver biochemical tests incidentally during an admission for an allergic reaction. Subsequent imaging to investigate this suggested a diagnosis of perihilar cholangiocarcinoma (ultrasound, CT, MRI, cholangiogram). Biopsy confirmed this to be of clear cell type on histology and immunohistochemistry. Diagnosis and further management of this rare entity was conducted in multidisciplinary meetings with the regional hepatobiliary centre. The patient was deemed unsuitable for surgical resection, underwent chemotherapy but died 1 year later.

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“…Clear cell cholangiocarcinoma (CCA) is a rare ICCA subtype characterized by extensive clear cell change [111][112][113]. Focal clear cell changes are common in ICCA; however, extensive or nearly all clear cell changes in ICCA is very rare.…”

Section: Clear Cell Cholangiocarcinomamentioning

confidence: 99%

Recent Advances in Pathology of Intrahepatic Cholangiocarcinoma

Choi,

Thung

2024

Preprint

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Intrahepatic cholangiocarcinoma (ICCA) is a malignant epithelial neoplasm characterized by biliary differentiation within the liver. ICCA is molecularly heterogeneous and exhibits a broad spectrum of histopathological features. It is a highly aggressive carcinoma with high mortality and poor survival rates. ICCAs are classified into two main subtypes: small duct type and large duct types. These two tumor types have different cell origins and clinicopathological features. ICCAs are characterized by numerous molecular alterations, including mutations in KRAS, TP53, IDH1/2, ARID1A, BAP1, BRAF, SAMD4, and EGFR, and FGFR2 fusion. Two main molecular subtypes–inflammation and proliferation–have been proposed. Recent advances in high-throughput assays using next-generation sequencing have improved our understanding of ICCA pathogenesis and molecular genetics. The diagnosis of ICCA poses a significant challenge for pathologists because of its varied morphologies and phenotypes. Accurate diagnosis of ICCA is essential for effective patient management and prognostic determination. This article provides an updated overview of ICCA pathology, focusing particularly on molecular features, histological subtypes, and diagnostic approaches.

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Intrahepatic clear cell cholangiocarcinoma - An uncommon histologic subtype: case report and literature review

Cited by 5 publications

References 10 publications

Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery

Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery

Perihilar clear cell cholangiocarcinoma: an often-diagnostic challenge

Recent Advances in Pathology of Intrahepatic Cholangiocarcinoma

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