Intrahepatic Jaundice due to Warfarin Therapy

Rehnqvist, Nina

doi:10.1111/j.0954-6820.1978.tb08449.x

Cited by 25 publications

(2 citation statements)

References 6 publications

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“…The results of liver tests were not reported. Finally, the first report on warfarin-induced cholestasis not only suggests dicoumarol-induced liver damage but also cross-reactivity between warfarin and dicoumarol (7). However, the causality is based on the persistence of increased enzyme levels when dicoumarol was given instead of warfarin, with decreasing enzyme values after anticoagulant therapy ceased.…”

Section: Fulminant Hepatic Failurementioning

confidence: 99%

“…Intrahepatic hematomas have also been observed after the administration of coumarins (4). Cholestatic and hepatocellular reactions have been associated with phenindione (5,6) as well as the coumarins: warfarin seems to induce mainly cholestatic reactions (7)(8)(9), whereas after phenprocoumon a hepatitis-like picture is usually observed (10) with a histological picture of acute or even chronic active hepatitis (1 1). According to a recent report, cross-reactivity between phenprocoumon and warfarin may even occur (12).…”

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confidence: 99%

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Fulminant hepatic failure associated with dicoumarol therapy

Castedal

Aldenborg

Olsson

1998

Liver

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— Coumarins have been associated with non‐predictable hepatic injury. In the case of dicoumarol, there is no hard evidence in the literature of a causal connection with liver damage. We report the case of a 73‐year‐old woman who developed a fatal liver disease of a mixed hepatocellular‐cholestatic type after 3 months of treatment with dicoumarol. A thorough diagnostic work‐up did not reveal any other possible cause of the liver disease.

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Section: Fulminant Hepatic Failurementioning

confidence: 99%

mentioning

confidence: 99%