Intrahepatic triglyceride content is independently associated with chronic kidney disease in obese adults: A cross-sectional study

Pan, Lingling; Zhang, Huijie; Huang, Zida; Sun, Qian; Chen, Zheng; Li, Zhibin; Yang, Shuyu; Li, Xiaoying; Li, Xuejun

doi:10.1016/j.metabol.2015.06.003

Cited by 30 publications

(28 citation statements)

References 47 publications

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“…Lastly, we did not find statistically significant correlation between the hepatic and renal FF, despite both being higher in the DM2 cohorts. While this is consistent with another MRI study comparing hepatic and renal FF (21), several other non-imaging studies have shown a link between nonalcoholic fatty liver disease (NAFLD) and CKD (32,33). The pathogenesis of steatosis in liver and kidney are fundamentally different so it is conceivable that there may be discordance in specific metabolic conditions.…”

Section: Discussionsupporting

confidence: 90%

Quantification of renal steatosis in type II diabetes mellitus using dixon‐based MRI

Yokoo

Clark

Pedrosa

et al. 2016

Magnetic Resonance Imaging

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Purpose To evaluate renal lipid content in subjects with and without type II diabetes mellitus (DM2) using Dixon-based magnetic resonance imaging (MRI). Materials and Methods This retrospective study was approved by institutional review board and compliant with Health Insurance Portability and Accountability Act. Sixty-nine adults with or without DM2 (n=29, n=40) underwent 3T MRI of the abdomen using 3D multiecho Dixon gradient-echo acquisition and proton-density fat fraction (FF) reconstruction. FF values were recorded within segmented regions of interest in the kidneys and liver. The FF measurement error was estimated from the within-subject difference between the right and left kidneys using Bland-Altman Analysis. Correlation between renal FF, hepatic FF, and body mass index (BMI) was evaluated. The association between renal FF and DM2 was evaluated by Wilcoxon rank sum test as well as by multivariate regression to correct for potential confounding effects of age, sex, BMI, creatinine, and hepatic FF. P-values <0.05 were considered statistically significant. Results Per-subject 95% limit of agreement of the renal FF measurement was [−3.26%, +3.22%]. BMI was significantly correlated to renal FF (r=0.266, p=0.027) and to liver FF (r=0.344, p=0.006). Correlation between renal and hepatic FF did not reach statistical significance (r=0.215, p=0.090). Median renal FF (±interquartile range) was 2.18% (±2.52%) in the DM2 cohort, significantly higher than 0.80% (±2.63%) in the non-DM2 cohort (p<0.001). After correcting for potential confounders, the relationship between DM2 and renal FF remained statistically significant (p=0.005). Conclusion Renal lipid content can be measured noninvasively using Dixon-based MRI and may be increased in subjects with DM2 compared to those without DM2.

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Section: Discussionsupporting

confidence: 90%

Quantification of renal steatosis in type II diabetes mellitus using dixon‐based MRI

Yokoo

Clark

Pedrosa

et al. 2016

Magnetic Resonance Imaging

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“…The details of the study design and methods have been previously reported29. In brief, a total of 485 adult obese subjects (waist circumference ≥ 90 cm for men or 80 cm for women) who received a carotid ultrasound for the measurement of carotid intima-media thickness were included in the analysis.…”

Section: Methodsmentioning

confidence: 99%

Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults

Jiang

Lin

et al. 2016

Sci Rep

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Neuregulin 4 (Nrg4) has been identified as a new secreted adipokine that may protect against development of obesity and metabolic disorders. However, information is not available regarding the association between circulating Nrg4 and subclinical atherosclerosis in humans. We measured serum Nrg4 in 485 obese adult subjects (aged 40 years or older) who had the measurement of carotid intima-media thickness (CIMT) recruited from the community. Individuals with increased CIMT and carotid plaque had lower levels of circulating Nrg4 than controls (p < 0.05). The risks of increased CIMT and atherosclerotic plaque were significantly decreased by 28% and 31% [OR (95% CI): 0.72 (0.53–0.98) and 0.69 (0.50–0.96), respectively], adjusting for age, sex, current smoking, alcohol consumption, physical activity, BMI, systolic BP, fasting glucose, total cholesterol, HDL-c, HOMA-IR, and body fat. Importantly, individuals in the lowest quartile of serum Nrg4 were 3.70 times (p < 0.001) more likely to have increased CIMT and 2.06 times (p < 0.05) more likely to have atherosclerotic plaque than those in the highest quartile in multivariable logistic regression analyses. These findings suggest that circulating Nrg4 concentrations are inversely associated with subclinical atherosclerosis in obese adults, and indicating that circulating Nrg4 might play a role in identifying patients at high risk for CVD.

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“…Several studies have reported associations between NAFLD and subclinical atherosclerosis and between NAFLD and cardiac function alterations, independently of established risk factors [5,6,7]. In addition, emerging evidence suggests that subjects with NAFLD have an increased risk of chronic kidney disease (CKD), defined by a decline in the estimated glomerular filtration rate (eGFR) and/or microalbuminuria and/or overt proteinuria [8,9,10,11,12]. However, no data are available in children regarding a possible association between NAFLD and impaired renal function.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Nonalcoholic Fatty Liver Disease on Renal Function in Children with Overweight/Obesity

Pacifico

Bonci

Andreoli

et al. 2016

IJMS

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The association between nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease has attracted interest and attention over recent years. However, no data are available in children. We determined whether children with NAFLD show signs of renal functional alterations, as determined by estimated glomerular filtration rate (eGFR) and urinary albumin excretion. We studied 596 children with overweight/obesity, 268 with NAFLD (hepatic fat fraction ≥5% on magnetic resonance imaging) and 328 without NAFLD, and 130 healthy normal-weight controls. Decreased GFR was defined as eGFR < 90 mL/min/1.73 m2. Abnormal albuminuria was defined as urinary excretion of ≥30 mg/24 h of albumin. A greater prevalence of eGFR < 90 mL/min/1.73 m2 was observed in patients with NAFLD compared to those without liver involvement and healthy subjects (17.5% vs. 6.7% vs. 0.77%; p < 0.0001). The proportion of children with abnormal albuminuria was also higher in the NAFLD group compared to those without NAFLD, and controls (9.3% vs. 4.0% vs. 0; p < 0.0001). Multivariate logistic regression analysis revealed that NAFLD was associated with decreased eGFR and/or microalbuminuria (odds ratio, 2.54 (confidence interval, 1.16–5.57); p < 0.05) independently of anthropometric and clinical variables. Children with NAFLD are at risk for early renal dysfunction. Recognition of this abnormality in the young may help to prevent the ongoing development of the disease.

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Intrahepatic triglyceride content is independently associated with chronic kidney disease in obese adults: A cross-sectional study

Cited by 30 publications

References 47 publications

Quantification of renal steatosis in type II diabetes mellitus using dixon‐based MRI

Quantification of renal steatosis in type II diabetes mellitus using dixon‐based MRI

Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults

The Impact of Nonalcoholic Fatty Liver Disease on Renal Function in Children with Overweight/Obesity

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