Intrahospital supervised exercise training: a complementary tool in the therapeutic armamentarium against childhood leukemia

Lucı́a, Alejandro; Ramı́rez, Manuel; Juan, Alejandro F. San; Fleck, Steven J.; García‐Castro, Javier; Madero, Luís

doi:10.1038/sj.leu.2403799

Cited by 26 publications

(19 citation statements)

References 36 publications

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“…While other studies have shown improvement in these outcomes in late maintenance or survivorship, our study did not generate any data for intervals when children were completely off drug treatment. Beginning shortly after diagnosis and following participants through the end of therapy, however, may have resulted in the study participants/parents simply being too sick/overwhelmed particularly at T 0 –T 2 to complete the intervention with the frequency and intensity necessary to improve function; they eventually may have experienced intervention fatigue over the 30‐month timeframe.…”

Section: Discussionmentioning

confidence: 85%

“…With a survival rate exceeding 93%, children with ALL have a potentially positive future if intervention can diminish early loss of physical function and modify the later effects of therapy. Recent reports urge early physical activity to minimize the sequelae of treatment in childhood cancer survivors; prescribed physical activity, even at low intensity and duration levels, has demonstrated changes in remarkably short periods of time in young cancer patients and survivors . However, the physical activity interventions for ALL that have been tested have started after functional loss has occurred, involved small and/or nonrandomized samples, been of short duration, and had minimal or no follow‐up to monitor behavior sustainability and durability.…”

Section: Introductionmentioning

confidence: 99%

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Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia

Cox

Zhu

Kaste

et al. 2017

Pediatric Blood & Cancer

100

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The intervention delivered during treatment was not successful in modifying BMD, physical function, or HRQL. Physical activity, at the level and intensity required to modify these factors, may not be feasible during early treatment owing to the child's responses to the disease and treatment. Future studies will consider intervention implementation during late maintenance therapy, extending into survivorship.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia

Cox

Zhu

Kaste

et al. 2017

Pediatric Blood & Cancer

100

View full text Add to dashboard Cite

show abstract

“…82,83 The experts highlight the potential health benefits of an enhanced physical fitness and well-being in survivors of cancer. 77,82,84 In this regard, Lucia et al 85 have indicated that even although exercise training most likely will not improve survival rates, supervised exercise has the potential to considerably improve children's quality of life and overall health status during treatment periods.…”

Section: Physical Fitness and Cancermentioning

confidence: 99%

Physical fitness in childhood and adolescence: a powerful marker of health

et al. 2007

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This review aims to summarize the latest developments with regard to physical fitness and several health outcomes in young people. The literature reviewed suggests that (1) cardiorespiratory fitness levels are associated with total and abdominal adiposity; (2) both cardiorespiratory and muscular fitness are shown to be associated with established and emerging cardiovascular disease risk factors; (3) improvements in muscular fitness and speed/agility, rather than cardiorespiratory fitness, seem to have a positive effect on skeletal health; (4) both cardiorespiratory and muscular fitness enhancements are recommended in pediatric cancer patients/survivors in order to attenuate fatigue and improve their quality of life; and (5) improvements in cardiorespiratory fitness have positive effects on depression, anxiety, mood status and self-esteem, and seem also to be associated with a higher academic performance. In conclusion, health promotion policies and physical activity programs should be designed to improve cardiorespiratory fitness, but also two other physical fitness components such us muscular fitness and speed/agility. Schools may play an important role by identifying children with low physical fitness and by promoting positive health behaviors such as encouraging children to be active, with special emphasis on the intensity of the activity.

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“…Additionally to the medical, surgical and radiological treatment of cancer, specifi c physical exercise regimes to enhance quality of life (QoL) and to decrease or even prevent side eff ects have been established in the last time [2,9,14,33] . Despite a fast growing amount of publications describing the positive eff ects of this exercise modalities in adults, only limited attention is given to this eff ective supportive therapy in children [20,21] . For example San Juan et al [28] showed positive physiological and psychological eff ects in a study with children (aged 8 -16 years) undergoing a supervised exercise program.…”

Section: Introduction ▼mentioning

confidence: 98%

Implementation of Structured Physical Activity in the Pediatric Stem Cell Transplantation

et al. 2011

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The peripheral blood stem cell transplantation (PBSCT) represents a specific, but stressful therapy for hemato-oncological diseases. While for adults, data suggest positive eff ects for a supportive sport therapy, this question is not evaluated sufficiently for children. The objective of this study was to examine the integration of sports activity into pediatric PBSCT and to indicate attainable results. This 2-step case-control-study included 23 children and adolescents from the PBSCT: During the isolation phase 13 patients trained 3 times per week on a cycle ergometer and passed a course with different sports equipment. Apart from recording physiologic adaptations, quality of live was inquired in a pre-post design using questionnaires. Guided interviews according to necessity and requirements for sports activity at the PBSCT unit completed the evaluation and were used for the intervention as well as for the control group (n = 10) without sports therapy. On the ergometer, patients trained average 25 min with 0.6 watt / kg. In the majority, a loss of muscular power could be avoided. Quality of life and fatigue symptoms improved by trend. Interview analysis showed general acceptance of physical activity during PBSCT. After initial skepticism due to the additional burden, our implementation study showed the feasibility of supportive sports therapy in PBSCT. Quality and flexibility of the equipment should be higher than normal and different physical and psychological conditions of the patients should be anticipated and integrated into the training program.

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Intrahospital supervised exercise training: a complementary tool in the therapeutic armamentarium against childhood leukemia

Cited by 26 publications

References 36 publications

Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia

Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia

Physical fitness in childhood and adolescence: a powerful marker of health

Implementation of Structured Physical Activity in the Pediatric Stem Cell Transplantation

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