Intralaboratory validation of an analytical method for determining the migration of bis(2-ethylhexyl) adipate from packaging to fat foods

Bazilio, Fabio Silvestre; Bomfim, Marcus Vinicius Justo; Almeida, Renata dos Santos; Abrantes, Shirley de Mello Pereira

doi:10.1007/s00769-014-1055-6

Cited by 9 publications

(4 citation statements)

References 27 publications

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“…Different plasticizers such as acetyl tributyl citrate, tributyl aconitate, bis(2-ethylhexyl) adipate, and phthalates were also identified in the plastic wrappers analyzed. The main function of plasticizers is to improve the flexibility and processability of polymers [16,17,18]. Acetyl tributyl citrate and tributyl aconitate were identified in all of the samples, while bis(2-ethylhexyl) adipate was identified in all of the samples except in samples P1 and P7.…”

Section: Resultsmentioning

confidence: 99%

“…Acetyl tributyl citrate and tributyl aconitate were identified in all of the samples, while bis(2-ethylhexyl) adipate was identified in all of the samples except in samples P1 and P7. Due to its low cost, this compound is widely used, especially in polyvinyl chloride (PVC) films [16,17,19]. Among the phthalates, diethyl phthalate and bis(2-ethylhexyl) phthalate were detected in all of the samples except in sample P2 and P3.1, respectively.…”

Section: Resultsmentioning

confidence: 99%

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GC-MS Screening Analysis for the Identification of Potential Migrants in Plastic and Paper-Based Candy Wrappers

2018

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Food packaging materials may be a potential source of contamination through the migration of components from the material into foodstuffs. Potential migrants can be known substances such as additives (e.g., plasticizers, stabilizers, antioxidants, etc.), monomers, and so on. However, they can also be unknown substances, which could be non-intentionally added substances (NIAS). In the present study, non-targeted analysis using mass spectrometry coupled to gas chromatography (GC-MS) for the identification of migrants in plastic and paper-based candy wrappers was performed. Samples were analyzed after extraction with acetonitrile. Numerous compounds including N-alkanes, phthalates, acetyl tributyl citrate, tributyl aconitate, bis(2-ethylhexyl) adipate, butylated hydroxytoluene, etc. were identified. Many of the compounds detected in plastic samples are not included in the positive list of the authorized substances. One non-intentionally added substance, 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6-9-diene-2,8-dione, which has been reported as a degradation product of the antioxidant Irganox 1010, was found in several samples of both plastic and paper packaging. The proposed method was shown to be a useful approach for the identification of potential migrants in packaging samples. The toxicity of the compounds identified was estimated according to Cramer rules. Then, a second targeted analysis was also conducted in order to identify photoinitiators; among the analyzed compounds, only 2-hydroxybenzophenone was found in five samples.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

GC-MS Screening Analysis for the Identification of Potential Migrants in Plastic and Paper-Based Candy Wrappers

2018

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“…45 e Bazilio e colaboradores. 46 Avaliação da precisão intermediária nas análises quantitativas dos princípios ativos do comprimido DFC 2 em 1.…”

Section: Teste De Efeito Matriz Para Isoniazida E Rifampicinaunclassified

“…O valor de coeficiente de variação da precisão intermediária obtido foi avaliado conforme Horwitz e Albert 45 e Bazilio e colabioradores. 46 …”

Section: Teste De Efeito Matriz Para Isoniazida E Rifampicinaunclassified

Analytical Method Validation for Determination of Tuberculostatics in Fixed Dose Combination by Capillary Electrophoresis

Castex

Abrantes

2017

Rev. Virtual Quim.

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Abstract:The World Health Organization (WHO) has proposed a standard therapeutic protocol for tuberculosis utilizing combinations of drugs formulated in fixed and appropriated doses according to the phases of the disease and weight range of patients. This guidance aimed to reduce the occurrence of new cases and to minimize the development of resistance to the drugs involved in this therapy. In these combinations, isoniazid and rifampicin are always present. At the same time, to fight such a disease like tuberculosis, which is funded by the Brazilian public health system, the availability of analytic methods that are reliable, fast, low cost and less polluting, compared to liquid chromatography (HPLC), shows to be extremely important to the public budget, particularly in Brazil, that has achieved the sixth position in the world´s drug consumer´s market. Capillary Electrophoresis (CE) is an analytical tool that has been rapidly growing in the last two decades for being a technique of hig h performance and low cost requiring low volume samples and little or no use of organic solvents further on low environmental impact. This work was carried out a method validation for the analysis of isoniazid and rifampicin in tablets of Fixed Dose Combination (FDC) by CE. The used analytical method proved to be useful for quantitative determination of isoniazid and rifampicin in FDC tablets. It was proved that the working range is linear for the concentration interval of 200 to 700 µg/mL and 500 to 1000 µg/mL for isoniazid and rifampicin, respectively. The matrix of DFC 2 in 1 tablet does not interfere in the results for the analysis of isoniazid and rifampicin (no matrix effect). Method repeatabilities for rifampicin and isoniazid of 3.17 % and 2.64 %, respectively, were acceptable when compared by the acceptance criterion of 3.30 % for variation coefficient of repeatability calculated by Horwitz equation. Intermediate precisions of isoniazid and rifampicin of 1.41 % and 1.67 %, respectively, were acceptable when compared to the variation coefficients of reproducibility of 1.97 % and 1.67 % for isoniazid and rifampicin, respectively, calculated by Horwitz equation. Recuperation of 95.00 % for isoniazid and 97.59 % for rifampicin were acceptable for the criteria of acceptance of the European Community of 80 to 110 % for the concentration studied.Keywords: Isoniazid; Rifampicin; Capillary Electrophoresis; Validation. ResumoA Organização Mundial de Saúde (OMS) propôs o protocolo de tratamento quimioterápico padrão para tuberculose utilizando associações de fármacos formulados em doses fixas e adequadas conforme a fase da doença e faixa de peso do paciente. Essa medida visou reduz ir a ocorrência de novos casos da doença e minimizar o desenvolvimento de resistência aos medicamentos envolvidos na terapia. Nessas associações, a isoniazida e a rifampicina estão sempre presentes. Ao mesmo tempo, para o combate de uma doença como a tuberculose, cujo custeio se faz gratuitamente pelo sistema público de saúde brasileiro, a disponibilizaçã...

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Synthesized the cold-resistant plasticizer epoxidized 1,6-hexanediol oleate and effects on the properties of polyvinyl chloride

Dong,

Xue,

Nan

et al. 2024

Polym. Bull.

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Intralaboratory validation of an analytical method for determining the migration of bis(2-ethylhexyl) adipate from packaging to fat foods

Cited by 9 publications

References 27 publications

GC-MS Screening Analysis for the Identification of Potential Migrants in Plastic and Paper-Based Candy Wrappers

GC-MS Screening Analysis for the Identification of Potential Migrants in Plastic and Paper-Based Candy Wrappers

Analytical Method Validation for Determination of Tuberculostatics in Fixed Dose Combination by Capillary Electrophoresis

Synthesized the cold-resistant plasticizer epoxidized 1,6-hexanediol oleate and effects on the properties of polyvinyl chloride

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