Intralesional 5-Fluorouracil for the Nonsurgical Management of Low-Risk, Invasive Squamous Cell Carcinoma

Dando, Emily; Lim, Geoffrey F.S.; Lim, Scott J.M.; Kim, Changhyun; Pugliano‐Mauro, Melissa

doi:10.1097/dss.0000000000001740

Cited by 8 publications

(4 citation statements)

References 4 publications

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“…A phase 1 clinical trial (NCT03370406) is recruiting patients with cSCC in the lower extremities for treatment with il5-FU and topical imiquimod [ 55 ]. il5-FU is a well-tolerated procedure, with adverse events being mostly mild and local (pain and injection site reactions) and rarely systemic (including headache, dizziness, and nausea) [ 51 , 53 , 54 , 56 , 57 ]. Follow-up time has been inconsistent among the case reports and series, most of them less than 1 year, if stated [ 7 , 51 ].…”

Section: Classic Treatmentsmentioning

confidence: 99%

Intralesional Treatments for Invasive Cutaneous Squamous Cell Carcinoma

Baeza-Hernández,

Cañueto

2023

Cancers

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Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans and has the potential to progress locally, metastasize, and cause death in a subset of patients. cSCC is especially common in the elderly, and it will probably represent a major health concern in the near future. Surgery is the standard treatment for cSCC, but intralesional therapies can sometimes be considered for certain patients and under certain circumstances. The choice of intralesional treatment depends on the patient′s characteristics and the clinician′s previous experience and expertise. Here we are reviewing intralesional treatments for cSCC and keratoacanthoma (KA). We have started with some classic drugs, such as methotrexate and 5-fluorouracil, bleomycin, interferon, and cryosurgery, but also comment on electrochemotherapy. Finally, we have focused on novel therapies, some of which are under development, and future perspectives, including intralesional immunotherapy and oncolytic viruses.

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Section: Classic Treatmentsmentioning

confidence: 99%

Intralesional Treatments for Invasive Cutaneous Squamous Cell Carcinoma

Baeza-Hernández,

Cañueto

2023

Cancers

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“…It is a treatment option for cutaneous SCC. 4 Mohs micrographic surgery—Correct. Treatment historically of a nipple adenoma has been complete elective excision of the tumor.…”

Section: Case Presentationmentioning

confidence: 99%

“…There are no reports of intralesional fluorouracil for treating nipple adenoma. It is a treatment option for cutaneous SCC 4.…”

mentioning

confidence: 99%

Erosion on the nipple

2020

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A 67-year-old white woman presented with a 12-month history of a nonhealing erosion on her right nipple. She reported intermittent itching, bleeding, and crusting. Physical examination revealed a 1.2 3 1.0-cm erosion on the right nipple (Fig 1). Her medical history was remarkable for chronic lymphocytic leukemia, rheumatoid arthritis, and multiple prior basal cell carcinomas. No other palpable masses within either breast or lymphadenopathy were appreciated. Mammography result was unremarkable. Punch biopsy of the patient's nipple was performed (Figs 2 and 3). Question 1: Considering clinical and histopathologic images, what is the most likely diagnosis? A. Nipple dermatitis B. Hyperkeratosis of the nipple and areola C. Mammary Paget disease D. Nipple adenoma E. Intraepidermal squamous cell carcinoma (SCC) Answers: A. Nipple dermatitis-Incorrect. Nipple dermatitis is a localized dermatitis of the nipple-areolar

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“…It is likely that salvage radiation therapy and IL 5-FU impaired wound healing and contributed to the patient's chronic nonhealing ulcer. 2,3 The decision to perform cryotherapy and a second surgery was also of questionable benefit, given her limited life expectancy (LLE) and, therefore, her minimal risk of dying from the SCC itself. 4,5 Specifically, a review of LLE patients with nonmelanoma skin cancer (NMSC) showed that while 43% of patients died within 5 years, none died from NMSC.…”

mentioning

confidence: 99%

Osteonecrosis of the calvarium: When clear margins are an impractical goal

Liakos

Siddiqui

Toussi

et al. 2020

Dermatologic Therapy

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patients with NMSC. 4 Our case demonstrates that the approach to NMSC therapy should take into consideration patient life expectancy, functional status, and personal preferences in order to avoid iatrogenic harm. 7 CONSENT Informed consent was obtained from the patient. CONFLICT OF INTEREST The authors involved have no reported relevant financial relationships with commercial interest(s). AUTHOR CONTRIBUTIONS William Liakos helped with figure preparation and wrote the manuscript. Fariha Siddiqui, Atrin Toussi, and Sara Kian worked with figure preparation, wrote the manuscript, and edited the manuscript.

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Intralesional 5-Fluorouracil for the Nonsurgical Management of Low-Risk, Invasive Squamous Cell Carcinoma

Cited by 8 publications

References 4 publications

Intralesional Treatments for Invasive Cutaneous Squamous Cell Carcinoma

Intralesional Treatments for Invasive Cutaneous Squamous Cell Carcinoma

Erosion on the nipple

Osteonecrosis of the calvarium: When clear margins are an impractical goal

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