Intralesional 5-fluorouracil (FU) as a treatment for nonmelanoma skin cancer (NMSC): A review

Metterle, Lauren; Nelson, Christopher G.; Patel, Nishit

doi:10.1016/j.jaad.2015.09.040

Cited by 47 publications

(42 citation statements)

References 25 publications

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“…Management can be challenging and evidence‐based treatment guidelines are lacking. Multiple off‐label options aimed at managing ulceration and destruction have been reported, including topical 5‐fluorouracil (5‐FU) and imiquimod, as well as intralesional 5‐FU, methotrexate and bleomycin, for which safety in OTR has not been determined . Topical 5‐FU under zinc oxide‐impregnated compression bandages (chemowraps) can be an effective treatment option .…”

Section: Management Of Eruptive Keratoacanthomas/cutaneous Squamous Cmentioning

confidence: 99%

Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients

Blomberg

Harwood

et al. 2017

Br J Dermatol

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Summary Although tremendous progress has been made in recent years in skin cancer care for organ transplant recipients, significant gaps remain in data-driven clinical guidelines, particularly for the treatment and prevention of cutaneous squamous cell carcinoma (cSCC), the most common malignancy among this population. In this review, we aim to summarize current knowledge around the management of cSCC and highlight the most significant gaps in knowledge that continue to pose challenges in the delivery of skin cancer care for organ transplant recipients. We suggest future directions for research that will bridge existing gaps and establish evidence-driven guidelines for primary prevention, screening and treatment of cSCC in this high-risk patient population.

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Section: Management Of Eruptive Keratoacanthomas/cutaneous Squamous Cmentioning

confidence: 99%

Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients

Blomberg

Harwood

et al. 2017

Br J Dermatol

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“…Intralesional therapies nowadays include: bleomycin, 5-FU, methotrexate, and various interferons, but most studies are small case series with fewer than 20 patients [14] . …”

Section: Novel Therapeutic Options For Nmscsmentioning

confidence: 99%

“…Tumor development and progression are determined by the interplay between these intricate processes [13]. In SCC, the metastatic rates are estimated as high as 5% [14]. In oral SCC, for instance, cell adhesion molecules (specifically CD44, members of the tumor necrosis factor, cytokine family like FasL and TRAIL, some interleukins, ILs, such as IL-6, IL-8, IL-12, and IL-23, vascular endothelial growth factor, and epidermal growth factor receptor, EGFR) play an important role in metastases [15].…”

Section: Introductionmentioning

confidence: 99%

Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

Fernandes

Santos²,

Kovačević³

et al. 2017

Skin Pharmacol Physiol

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Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. AKs are precursor lesions of cutaneous SCCs. The classical therapy of NMSCs makes use of photodynamic therapy associated with chemotherapeutics. With improved understanding of the pathological mechanisms of tumor initiation, progression, and differentiation, a case is made towards the use of targeted chemotherapy with the intent to reduce the cytotoxicity of classical treatments. The present review aims to describe the current state of the art on the knowledge of NMSC, including its risks factors, oncogenes, and skin carcinogenesis, discussing the classical therapy against new therapeutic options.

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“…El cáncer de piel no melanoma es el cáncer más común e incluye el carcinoma de células basales y el carcinoma de células escamosas (CCE) 1 . La base y el modelo para resolver el problema del cáncer de la piel es la cirugía 1,2 . Ambas enfermedades comparten el hecho que entre sus factores de riesgo más importantes se considera la exposición acumulativa a la radiación UV, la exposición a arsénico inorgánico, individuos de piel clara, piel dañada por el sol, la población mayor de 60 años e infecciones virales [3][4][5][6][7][8] .…”

Section: Introductionunclassified

Carcinoma de células escamosas de piel. Serie de casos

et al. 2018

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Introduction: Squamous skin cancer (SSC) is the second most frequent skin cáncer, nevertheless reports about this issue are not published in Chile. Objetive: To investigate social, demographics, and clinic characteristics of SSC in semidesertic Coquimbo Region, Chile. Material and Methods: serie of patients diagnosed and treated in Coquimbo hospital between January 2006 and December 2015. Inclussion criteria: 1.-histopathological confirmation of SSC. Exclusion criteria: 1.-follow up lesser than 12 months; 2.-operated in another hospital; 3.-submitted to another treatment prior to surgery; 4.-skin metastasis of mucous squamous carcinoma; 5.-patients with distant metástasis. Independent variables: age, gender, tumor site, tumor size, clinical lymph nodes, shore or valley residency. Dependent variable: recurrency frecuence, factors of recurrency, letality. Statistical analysis: descriptive and analytical by SSPS program.Results: 2.202 skin cancer cases were registered, 1.487 basal cells carcinoma (67.5%), 181 melanoma (8.2%) and 534 squamous cells carcinoma (24.2%). 236 patients with complete data are included in this report. There were 153 men (64.8%), and 83 women (35.2%). Mean age was 75.5 years old ± 11.7 (range 46-94). Primary site was: head 158 patients (66.9%), other sun exposed areas 47 patients (20%), and non exposed areas 31 patients. Cheek and front were the most frequents head site with 40 cases (25%) and 29 cases (12.3%), respectively. In 119 cases (50.4%) SCC was ulcerated, and 117 cases was not; primary tumor diameter was 22 millimeters (range 3-100). Clinical lymph nodes were primarily positives in 10 patients, (4.2%). In 12 cases with negative lymph nodes, sentinel limph node was resected. 2 were positives. Histological borders were tumor free in 201 patients (85.2%) and, 35 cases (14.8%) had positive histological borders. Local recurrence incidence was 8.5% (20 cases). Limph nodes recurrence was 2.1% (5 cases). Cancer recurrence was associated with histological positive borders P = 0.001, IC 95% 3.12-12.19, and ulcerated tumor p = 0.01, OR 4.63; IC 1.59-13.50. Letality was 2.56%. Mean follow up was 36 months (range 12-228 months). Conclusions: SSC has a good prognosis when primary tumor is resected early, with free histological borders resection.

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Intralesional 5-fluorouracil (FU) as a treatment for nonmelanoma skin cancer (NMSC): A review

Cited by 47 publications

References 25 publications

Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients

Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients

Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

Carcinoma de células escamosas de piel. Serie de casos

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