Intralesional Bleomycin Injections for Vascular Malformations

Abstract

Therapeutic, IV.

Foamed bleomycin sclerosis of airway venous malformations: The role of interspecialty collaboration

“…The smaller airway of this younger patient may have contributed to symptomatic edema. Nonetheless, our findings agree with a recent randomized comparison and meta‐analysis, which both demonstrate a significantly higher complication rate for ethanol VMPS than for bleomycin VMPS.…”

Stereological comparison of intraprostatic injection of alcohol and bleomycin with finasteride gavages in the rats

“…They further claimed that bleomycin treatment might be better tolerated and is thus preferred over alcohol sclerotherapy [20]. Efficacy of bleomycin in reducing the size of lymphatic and venous malformation as well as fewer severe complications has given it priority over other sclerosing agents [21]. The present study is a preliminary animal experiment of the application of bleomycin and future work should be followed and completed in human research.…”

Development of an international core outcome set for peripheral vascular malformations: the OVAMA project

“…size, colour and shape/texture of the vascular malformation and distortion of bodily or facial features) did not achieve consensus in the e‐Delphi rounds, as most published studies used size reduction based on the clinical appearance of the vascular malformation, as a primary outcome measure. In a meta‐analysis on bleomycin sclerotherapy, size reduction of the vascular malformation was measured in 24 of 27 included studies, and in most of these studies ( n = 20) evaluation of size reduction was based on the appearance of the vascular malformation on physical examination.…”

“…In only four of the studies included in the above‐mentioned review, radiological imaging was performed to measure the exact size reduction. Radiological assessment was included in the COS; however, in the next steps of the OVAMA project, we need to determine whether follow‐up imaging to evaluate treatment outcome is feasible in all cases (e.g.…”

“…Although many different treatment options are available in the literature, evidence‐based treatment guidelines are not readily available. A main reason for the lack of these guidelines is the variety of methods used to evaluate the efficacy of treatment in clinical research . Therefore, study results cannot be compared easily nor aggregated into meta‐analyses.…”