Intralesional corticosteroid injections for the treatment of oral lichen planus: A systematic review

Alsubhi, Aliyah; Salem, Noura; Mohab, Maryam; Alghamdi, Bashaer; Alghamdi, N. A.; Alasiri, Raniya A.; Sindi, Rajwa A; Almastadi, Raneem A; Alfayez, Noor M; Alsulaimani, Mawaddah; Alsheikh, Weaam; Alhamed, Sana; Mawardi, Hani

doi:10.4103/jdds.jdds_76_19

Cited by 2 publications

(5 citation statements)

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“…31 Topical, intra-lesional, and systemic corticosteroids are available; topical application is the most common. 32 Topical medications, on the other hand, cannot stay on the oral mucosa for long periods and are thus poorly absorbed. 33 The restricted efficacy of topical treatments is improved by using an intralesional injection technique.…”

Section: Discussionmentioning

confidence: 99%

Efficacy Of Triamcinolone Injection In Management Of Oral Lichen Planus

Iqbal,

Luqman,

Zulfiqar

et al. 2024

JRMC

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Objective: To study the efficacy of triamcinolone injection in the treatment of oral lichen planus patients presented to the department of oral and maxillofacial surgery at KRL General Hospital Islamabad. Method: This study was conducted in the Department of Oral & Maxillofacial Surgery, Kahuta Research Laboratories Islamabad. 100 patients who fulfilled the inclusion-exclusion criteria were selected. All the enrolled patients were treated with intralesional TA injection once a week for 4 weeks. A 0.5ml TA (40mg/ml) dose was used. The subepithelial tissue just beneath the lesion and next to the normal mucosa was the exact location of the injection. The treatment was stopped earlier when all three of the symptoms of burning, pain and patch colour were removed. The patients were examined clinically on the 7th, 14th, and 21st day of treatment and based on the examination, the decision of the next dose was decided. The final examination of the patient was on the 28th day of treatment. To assess the oral pain and burning, we used the Visual Analogue Scale (VAS) having 10 grades (0-10). Results: The mean age of the patients in the study was 35.47±13.459 ranging from 18 to 65 years. In frequency of gender of the patients, there were 57(57%) male and 43(43.0%) female patients. In frequency of distribution of patients, 38(38.0%) patients had unilateral while the remaining 62(62.0%) had bilateral disorders. In frequency of efficacy, 87(87.0%) patients found with improved symptoms and 13(13.0%) were not improved/inefficient. Conclusion: This study concluded as much of previous literature concluded that the efficacy and safety of intralesional TA injection were found efficient after observation at 28th weeks of treatment. Keywords: Triamcinolone injection, Oral lichen planus, Efficacy, Reticular, Plaque.

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Section: Discussionmentioning

confidence: 99%

Efficacy Of Triamcinolone Injection In Management Of Oral Lichen Planus

Iqbal,

Luqman,

Zulfiqar

et al. 2024

JRMC

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“…However, TA intralesional injection treatment has many side effects; it requires several treatment sessions, is associated with pain from the injections themselves, and there is a tendency for recurrence within a short time after TA injection. Therefore, there is a need to develop safer and more effective therapies to manage OLP (Alsubhi et al, 2020;Eisen et al, 2005). CO 2 laser is considered the preferred treatment option for superficial mucosal lesions of the oral cavity (Condor et al, 2021;Huang et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Topical steroids have been considered the mainstay treatment of OLP as they have fewer side effects than systemic steroids (Gupta et al, 2017; Lodi et al, 2020). A recent systematic review considered intralesional corticosteroids as an effective treatment modality that causes fewer side effects than other topical corticosteroids, owing to the delivery of a high concentration of corticosteroids locally with minimal systemic absorption (Alsubhi et al, 2020; Lee et al, 2013). However, regarding the chronic nature and high recurrence rate of OLP, prolonged use of topical corticosteroids is required (Radwan‐Oczko, 2013), which could cause several side effects, such as secondary candidosis, thinning of the oral mucosa, a tingling or a burning sensation, and cushingoid features.…”

Section: Introductionmentioning

confidence: 99%

“…However, regarding the chronic nature and high recurrence rate of OLP, prolonged use of topical corticosteroids is required (Radwan‐Oczko, 2013), which could cause several side effects, such as secondary candidosis, thinning of the oral mucosa, a tingling or a burning sensation, and cushingoid features. Moreover, some patients with OLP are unresponsive or intolerant to corticosteroids (Alsubhi et al, 2020; Olson et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, some patients with OLP are unresponsive or intolerant to corticosteroids (Alsubhi et al, 2020;Olson et al, 2016).…”

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confidence: 99%

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CO₂ laser vaporisation in treating oral lichen planus: A split‐mouth randomised clinical trial

et al. 2023

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ObjectivesThis study aimed to compare the effectiveness of carbon dioxide (CO2) laser vaporisation versus intralesional injection of triamcinolone acetonide (TA) in the management of oral lichen planus (OLP).MethodsA randomised clinical trial with a split‐mouth design was conducted on 16 patients with bilateral symptomatic OLP lesions. One side was treated with CO2 laser vaporisation, and the counterpart was treated with TA intralesional injection. The reticular–erythematous–ulcerative (REU) score, Thongprasom sign scoring (TSS), visual analogue scale (VAS) and lesion area were used to evaluate the lesions at weeks 0, 4 and 9. All participants were followed up for 9 months.ResultsReduction in the REU, TSS scores and lesion area from baseline to the end of treatment was significantly greater in the CO2 group than in the TA group (p values were 0.001, 0.002 and 0.048 respectively). However, the reduction in VAS score did not differ between the two groups (p = 0.54). The recurrence rate was significantly higher in the TA group than in the CO2 group (75% vs. 31.1%; p = 0.016).ConclusionsCO2 laser vaporisation was more effective than TA intralesional injection in managing OLP and decreased recurrence rates.

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Intralesional corticosteroid injections for the treatment of oral lichen planus: A systematic review

Cited by 2 publications

References 16 publications

Efficacy Of Triamcinolone Injection In Management Of Oral Lichen Planus

Efficacy Of Triamcinolone Injection In Management Of Oral Lichen Planus

CO₂ laser vaporisation in treating oral lichen planus: A split‐mouth randomised clinical trial

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Intralesional corticosteroid injections for the treatment of oral lichen planus: A systematic review

Cited by 2 publications

References 16 publications

Efficacy Of Triamcinolone Injection In Management Of Oral Lichen Planus

Efficacy Of Triamcinolone Injection In Management Of Oral Lichen Planus

CO2 laser vaporisation in treating oral lichen planus: A split‐mouth randomised clinical trial

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CO₂ laser vaporisation in treating oral lichen planus: A split‐mouth randomised clinical trial