Intralesional Excision versus Wide Resection for Giant Cell Tumor Involving the Acetabulum: Which is Better?

Guo, Wei; Sun, Xin; Zang, Jie; Qu, Huayi

doi:10.1007/s11999-011-2190-6

Cited by 38 publications

(32 citation statements)

References 33 publications

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“…Publication dates ranged from 1949–2012. These papers included 165 patients, the largest series comprising 27 patients. Numerous case reports were included.…”

Section: Resultsmentioning

confidence: 99%

Giant Cell Tumor of the Pelvis: a Systematic Review

Zheng

Wang

et al. 2015

Orthopaedic Surgery

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This is a systematic review of articles concerning the morbidity, recurrence rate, treatment and treatment complications of pelvic giant cell tumors (GCTs). The key words "giant cell tumor, pelvis" were used to identify articles which included data on patients with pelvic GCTs in English and Chinese databases of published reports from 1949-2012. The articles were filtered by title, abstract and full text. Thirty-eight articles and 165 patients were identified for this review. Data on all identified patients were studies; data in different articles on the same patients was not used repeatedly. The following patient data were collected where possible and subjected to systematic analysis; age, location of GCT, treatment, follow-up, complications, recurrence and whether alive or dead. The mean age of onset was 33.2 years (range, 14-73 years), the peak ages of onset being between 21 and 40 years. A pronounced sex difference was identified, the male : female ratio being 1:1.7. The acetabulum was the commonest area for pelvic GCTs. Forty-eight tumors were primarily located in the iliac, 60 in the acetabular and 31 in the ischiopubic area. Twenty-seven patients experienced complications of treatment. Patients who had been treated by wide resection had the most complications; these included incisional infection and delayed healing of incisions. Local recurrence was common, having occurred in 39/158 patients (24.6%), comprising 24/72 (33.3%) who had undergone intralesional surgery only; 9/20 (45.0%) who had undergone radiotherapy only; 1/51 (2.0%) who had undergone wide resection; and 5/14 patients (35.7%) who had undergone radiation therapy or cryotherapy plus intralesional surgery. Mortality was low (3.2%, 5/158). Pelvic GCT is not common, the acetabular area appears to the most frequent site and the peak age is the third and fourth decades. Although the recurrence rate is high for all pelvic GCTs, the mortality is low. Treatment has a critical influence on recurrence. In spite of the associated complications, the lower local recurrence rate makes wide resection a reasonable option for patients with extensive and/or aggressive GCTs.

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“…Publication dates ranged from 1949–2012. These papers included 165 patients, the largest series comprising 27 patients. Numerous case reports were included.…”

Section: Resultsmentioning

confidence: 99%

Giant Cell Tumor of the Pelvis: a Systematic Review

Zheng

Wang

et al. 2015

Orthopaedic Surgery

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“…In this case, percutaneous cryoablation therapy was an alternative option for curative intent treatment of a GCT with extensive involvement of the pelvic bone and the A large resection surgery, such as a hemipelvectomy, might produce poor functional and esthetic results, and a more conservative surgical approach, such as curettage with the application of adjuvants, carries a high risk of local recurrence after a markedly morbid procedure [5].…”

Section: Discussionmentioning

confidence: 95%

Percutaneous CT-Guided Cryoablation as an Alternative Treatment for an Extensive Pelvic Bone Giant Cell Tumor

Panizza

Cavalcanti

Yamaguchi

et al. 2015

Cardiovasc Intervent Radiol

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A giant cell tumor (GCT) is an intermediate grade, locally aggressive neoplasia. Despite advances in surgical and clinical treatments, cases located on the spine and pelvic bones remain a significant challenge. Failure of clinical treatment with denosumab and patient refusal of surgical procedures (hemipelvectomy) led to the use of cryoablation. We report the use of percutaneous CT-guided cryoablation as an alternative treatment, shown to be a minimally invasive, safe, and effective option for a GCT with extensive involvement of the pelvic bones and allowed structural and functional preservation of the involved bones.

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“…Despite these reservations, some authors advocate this method in the proximal femur [15]. Whatever the method used, recurrences are frequent, occurring between a few months and five years, in proportions of 20% to 40% according to the series [16] [17] [18] [19]. In 15% of cases, it is malignant degeneration [20] [21] [22].…”

Section: Discussionmentioning

confidence: 99%

Clinical Case: Treatment of a Giant Cells Tumor of the Proximal Femur in a Disadvantaged Area

Sawadogo¹,

Korsaga²,

Tinto³

et al. 2017

OJO

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There have been not many reports on the result of intralesional excision for giant cell tumors (GCTs) of the great trochanter and femoral neck because of its rarity. The authors present the case of a 35-year-old female patient managed with intralesional curettage and filling the defect with autologous bone graft from iliac crest. An appoint of three doses of Denosumab was done postoperatively. The article discusses the clinical aspects and surgical treatment, and the benefits of Denosumab. This report aimed to demonstrate the possibility to perform curetage for giant cell tumor of the hip even the recommandation for this location is wide resection and endoprothesis fixation.

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Intralesional Excision versus Wide Resection for Giant Cell Tumor Involving the Acetabulum: Which is Better?

Cited by 38 publications

References 33 publications

Giant Cell Tumor of the Pelvis: a Systematic Review

Giant Cell Tumor of the Pelvis: a Systematic Review

Percutaneous CT-Guided Cryoablation as an Alternative Treatment for an Extensive Pelvic Bone Giant Cell Tumor

Clinical Case: Treatment of a Giant Cells Tumor of the Proximal Femur in a Disadvantaged Area

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