Intralesional Sodium Thiosulfate for the Treatment of Calciphylaxis

Strazzula, Lauren; Nigwekar, Sagar U.; Steele, David; Tsiaras, William G.; Sise, Meghan E.; Bis, Sabina; Smith, Gideon P.; Kroshinsky, Daniela

doi:10.1001/jamadermatol.2013.4565

Cited by 111 publications

(95 citation statements)

References 10 publications

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“…Our study cannot explain if the trend in mortality reduction is a result of treatments such as sodium thiosulfate, or whether it is due to increased awareness and early recognition of the disease. 36,37 A prospective study is needed to better understand calciphylaxis mortality rates and to assess the effectiveness of interventions to treat calciphylaxis. Similarly, unmasking detection signal bias and the possibility that increased awareness produced an apparent incidence increase cannot be entirely ruled out by any study of this nature.…”

Section: Discussionmentioning

confidence: 99%

Quantifying a Rare Disease in Administrative Data: The Example of Calciphylaxis

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Quantifying a Rare Disease in Administrative Data: The Example of Calciphylaxis

et al. 2014

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“…115,116 Intra-lesional sodium thiosulfate has also been described to aid in the resolution of calciphylaxis lesions. 117 …”

Section: Treatmentmentioning

confidence: 99%

Calciphylaxis: Risk Factors, Diagnosis, and Treatment

Nigwekar

Kroshinsky

Nazarian

et al. 2015

American Journal of Kidney Diseases

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Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in chronic kidney failure patients treated with dialysis (uremic calciphylaxis) but is also described in patients with earlier stages of chronic kidney disease and with normal renal function. In this In Practice feature, we review the available medical literature regarding risk factors, diagnosis, and treatment of both uremic and non-uremic calciphylaxis. High quality evidence for the evaluation and management of calciphylaxis is lacking at this time due to its rare incidence, poorly understood pathogenesis, and the relative paucity of collaborative research efforts. We hereby provide a summary of recommendations developed by the Massachusetts General Hospital's Multi-disciplinary Calciphylaxis Team for calciphylaxis patients.

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“…Intravenous sodium thiosulfate and removing potential triggers are the main medical treatment for calciphylaxis. Successful treatment with intralesional sodium thiosulfate injection was also reported [7]. Supportive treatment, such as pain control and wound care, are also very important as patients mostly suffer from severe pain complicated by wound infection.…”

Section: Discussionmentioning

confidence: 97%