Intralymphatic treatment of flagellin-ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis

Kim, E. H.; Kim, J. H.; Samivel, Ramachandran; Bae, Jong Seok; Chung, Young-Jun; Chung, Phil‐Sang; Lee, S. E.; Mo, Ji‐Hun

doi:10.1111/all.12839

Cited by 29 publications

(24 citation statements)

References 19 publications

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“…However, the serum IFN- γ content, the percentage of CD3 + CD4 + IFN- γ + Th1 cells in PBMCs, and the mRNA expression levels of IFN- γ , T-bet, and SATA-1 were all significantly increased compared with those in the normal control group; the same trend was observed for the serum IL-4 content, the percentage of CD3 + CD4 + IL-4 + Th2 cells in PBMCs, and the mRNA expression levels of IL-4, GATA-3, and SATA-6. In this study, Th1 and Th2 responses were simultaneously enhanced in a rat model of AR, consistent with the results of Kim et al who also used a mouse model of AR [41]. Two reasons are speculated to explain this phenomenon.…”

Section: Discussionsupporting

confidence: 92%

Mahuang Fuzi Xixin Decoction Attenuates Th1 and Th2 Responses in the Treatment of Ovalbumin-Induced Allergic Inflammation in a Rat Model of Allergic Rhinitis

Ren

Tang

Chen

et al. 2017

Journal of Immunology Research

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Allergic rhinitis (AR) is one of the most common allergic diseases, which adversely affect patients' quality of life. Mahuang Fuzi Xixin decoction (MFXD) has been widely used to treat AR in clinics in Asian countries. This study investigated the effect and possible therapeutic mechanisms of MFXD in the treatment of AR. A Wistar rat model of ovalbumin- (OVA-) induced AR was established and then treated with three doses of MFXD; AR symptoms, serum total immunoglobulin E, histamine, histopathological features, and release and expression of factors related to type 1 helper T (Th1) and type 2 helper T (Th2) responses were analyzed. Our study demonstrated that MFXD has a good therapeutic effect on OVA-induced allergic inflammation in an AR rat model as manifested in reduced frequencies of sneezing and nasal scratching and in reduced serum levels of total IgE and HIS. In addition, MFXD regulates imbalance in Th1/Th2 cells caused by AR by simultaneously attenuating Th1 and Th2 responses, such as by reducing the serum levels of IFN-γ and IL-4 and mRNA expression levels of IFN-γ, IL-4, GATA-3, and STAT-6. This study provided valuable information on the immunoregulatory effect of MFXD for the treatment of AR in future clinical studies.

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Section: Discussionsupporting

confidence: 92%

Mahuang Fuzi Xixin Decoction Attenuates Th1 and Th2 Responses in the Treatment of Ovalbumin-Induced Allergic Inflammation in a Rat Model of Allergic Rhinitis

Ren

Tang

Chen

et al. 2017

Journal of Immunology Research

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“…Results demonstrated that immunization with flagellin-fused proteins induced high antibody titers, seroconversion, and protection. Moreover, flagellin was also evaluated as a potent adjuvant to prevent rhinitis in mice [ 96 ].…”

Section: Classification Of Adjuvantsmentioning

confidence: 99%

Adjuvants: Classification,Modus Operandi, and Licensing

Apostólico

Lunardelli

Coirada

et al. 2016

Journal of Immunology Research

232

192

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Vaccination is one of the most efficient strategies for the prevention of infectious diseases. Although safer, subunit vaccines are poorly immunogenic and for this reason the use of adjuvants is strongly recommended. Since their discovery in the beginning of the 20th century, adjuvants have been used to improve immune responses that ultimately lead to protection against disease. The choice of the adjuvant is of utmost importance as it can stimulate protective immunity. Their mechanisms of action have now been revealed. Our increasing understanding of the immune system, and of correlates of protection, is helping in the development of new vaccine formulations for global infections. Nevertheless, few adjuvants are licensed for human vaccines and several formulations are now being evaluated in clinical trials. In this review, we briefly describe the most well known adjuvants used in experimental and clinical settings based on their main mechanisms of action and also highlight the requirements for licensing new vaccine formulations.

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“…A plethora of animal models for specific allergen immunotherapy tried optimizing the application mode and route of allergen, by entrapment in tolerogenic PLG particles [46 ▪▪ ], or application concomitantly with CpG [45], probiotics or Vitamin D3 (Table 1) [37–39,41,42 ▪ ,43 ▪▪ ,44,45,46 ▪▪ ,49 ▪ ,51]. In particular, epicutaneous application has achieved promising results without adjuvants [43 ▪▪ ].…”

Section: Resultsmentioning

confidence: 99%

“…In particular, epicutaneous application has achieved promising results without adjuvants [43 ▪▪ ]. On the basis of therapeutic mouse studies [49 ▪ ] and preventive approaches in horses [51], the frequency of usage of the intralymphatic route is expected to increase in the near future.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Outstanding animal studies in allergy II. From atopic barrier and microbiome to allergen-specific immunotherapy

Jensen‐Jarolim

Pali‐Schöll

Roth‐Walter

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewAnimal studies published within the past 18 months were assessed, focusing on innate and specific immunomodulation, providing knowledge of high translational relevance for human atopic and allergic diseases.Recent findingsAllergic companion animals represent alternative models, but most studies were done in mice. Atopic dermatitis mouse models were refined by the utilization of cytokines like IL-23 and relevant skin allergens or enzymes. A novel IL-6 reporter mouse allows biomonitoring of inflammation. Both skin pH and the (transferable) microflora have a pivotal role in modulating the skin barrier. The microflora of the gastrointestinal mucosa maintains tolerance to dietary compounds and can be disturbed by antiacid drugs. A key mouse study evidenced that dust from Amish households, but not from Hutterites protected mice against asthma. In studies on subcutaneous and sublingual allergen-specific immunotherapy, much focus was given on delivery and adjuvants, using poly-lacto-co-glycolic particles, CpGs, probiotics or Vitamin D3. The epicutaneous and intralymphatic routes showed promising results in mice and horses in terms of prophylactic and therapeutic allergy treatment.SummaryIn atopic dermatitis, food allergies and asthma, environmental factors, together with the resident microflora and barrier status, decide on sensitization versus tolerance. Also allergen-specific immunotherapy operates with immunomodulatory principles.

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Intralymphatic treatment of flagellin-ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis

Cited by 29 publications

References 19 publications

Mahuang Fuzi Xixin Decoction Attenuates Th1 and Th2 Responses in the Treatment of Ovalbumin-Induced Allergic Inflammation in a Rat Model of Allergic Rhinitis

Mahuang Fuzi Xixin Decoction Attenuates Th1 and Th2 Responses in the Treatment of Ovalbumin-Induced Allergic Inflammation in a Rat Model of Allergic Rhinitis

Adjuvants: Classification,Modus Operandi, and Licensing

Outstanding animal studies in allergy II. From atopic barrier and microbiome to allergen-specific immunotherapy

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