Intramammary and systemic use of antimicrobials and their association with resistance in generic Escherichia coli recovered from fecal samples from Canadian dairy herds: A cross-sectional study

Fonseca, Mariana; Heider, Luke C.; Stryhn, Henrik; McClure, J. Trenton; Léger, David; Rizzo, Daniella; Warder, Landon; Dufour, Simon; Roy, Jean-Philippe; Kelton, D.F.; Renaud, D.L.; Barkema, Herman W.; Sánchez, Javier

doi:10.1016/j.prevetmed.2023.105948

Cited by 6 publications

(1 citation statement)

References 47 publications

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“…A relaxed p-value ≤ 0.2 [ 54 – 57 ] was used to identify predictors that were chosen for further examination in the multivariable mixed-effect logistic regression models in step two. To prevent the inclusion of collinear variables in the multivariable models, the pairwise collinearity of these variables was examined using Spearman’s rank correlation coefficient.…”

Section: Methodsmentioning

confidence: 99%

Effect of veterinary feed directive rule changes on tetracycline-resistant and erythromycin-resistant bacteria (Salmonella, Escherichia, and Campylobacter) in retail meats in the United States

Sarkar

Okafor

2023

PLoS ONE

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Background Antimicrobial-resistant bacteria are a growing public health threat. In 2017 the U.S. Food and Drug Administration implemented Veterinary Feed Directive (VFD) rules changes to limit medically important antimicrobial use in food-producing animals, combating antimicrobial-resistant bacteria. The effect of the VFD rule changes on the occurrence of bacteria resistant to medically-important antimicrobials in retail meats is yet to be investigated in the U.S. This study investigates whether the VFD rule changes affected the occurrence of tetracycline-resistant and erythromycin-resistant bacteria (Salmonella, Escherichia, and Campylobacter) in retail meats in the U.S. Methods Multivariable mixed effect logistic regression models were used to analyze 2002–2019 retail meats surveillance data from the National Antimicrobial Resistance Monitoring System (NARMS) in the U.S. Variables included VFD rule changes, meat type, quarter of year, and raising claims. A potential association between these variables and the occurrence of tetracycline-resistant and erythromycin-resistant bacteria (Salmonella, Escherichia, and Campylobacter) in retail meats was estimated. Results Analysis included data regarding tetracycline-resistant Salmonella (n = 8,501), Escherichia (n = 20, 283), Campylobacter (n = 9,682), and erythromycin-resistant Campylobacter (n = 10,446) in retail meats. The odds of detecting tetracycline-resistant Escherichia (OR = 0.60), Campylobacter (OR = 0.89), and erythromycin-resistant Campylobacter (OR = 0.43) in chicken breast significantly decreased after the VFD rule changes, compared to the pre-VFD rule change period. The odds of detecting tetracycline-resistant Salmonella (0.66), Escherichia (OR = 0.56), and Campylobacter (OR = 0.33) in ground turkey also significantly decreased. However, the odds of detecting tetracycline-resistant Salmonella (OR = 1.49) in chicken breast and erythromycin-resistant Campylobacter (OR = 4.63) in ground turkey significantly increased. There was no significant change in the odds of detecting tetracycline-resistant Salmonella and Escherichia in ground beef or pork chops. Conclusions The implementation of VFD rule changes had a beneficial effect by reducing the occurrence of tetracycline-resistant and erythromycin-resistant bacteria in chicken and ground turkey. Ongoing surveillance of antimicrobial resistance and antimicrobial use could complement the implementation of stewardship such as VFD rule in food-producing animals in the U.S.

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Section: Methodsmentioning

confidence: 99%

Effect of veterinary feed directive rule changes on tetracycline-resistant and erythromycin-resistant bacteria (Salmonella, Escherichia, and Campylobacter) in retail meats in the United States

Sarkar

Okafor

2023

PLoS ONE

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Current status and trends in antimicrobial use in food animals in China, 2018–2020

Zhao,

Jiang,

et al. 2023

One Health Adv.

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Antimicrobial resistance poses a significant threat to global public health, and excessive antimicrobial use (AMU) in animals is a major contributing factor. We used national AMU data for food animals to examine the current status and trends for AMU in food animals in China from 2018–2020. In 2020, China used 32,776.30 tons of antimicrobials in food animals, amounting to 165 g of antimicrobials per ton of animal products. AMU in China increased throughout the 2018–2020 study period; however, the data still showed a consistent and notable reduction from those of 2017, coinciding with the implementation of the China National Action Plan for Combating Animal Antimicrobial Resistance. Among the antimicrobials used, tetracyclines, macrolides and β-lactams (including β-lactam inhibitors) were the most commonly used in food animals. Analysis by antimicrobial class revealed shifts in usage patterns, such as decreased tetracycline use and increased macrolide and β-lactam use. Furthermore, the use of antimicrobial growth promoters decreased sharply, from 51.78% in 2018 to 28.7% in 2020. Compared with AMU data from other countries, China used more antimicrobials, but the values were relatively lower when adjusted for population correction units. These findings highlight China's remarkable efforts in combating antimicrobial resistance and promoting antimicrobial stewardship, thus contributing significantly to global initiatives.

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Associations among antimicrobial use, calf management practices, and antimicrobial resistance in Escherichia coli from a pooled fecal sample in calves on Canadian dairy farms: A cross-sectional study

Uyama,

Kelton,

Morrison

et al. 2024

Journal of Dairy Science

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Intramammary and systemic use of antimicrobials and their association with resistance in generic Escherichia coli recovered from fecal samples from Canadian dairy herds: A cross-sectional study

Cited by 6 publications

References 47 publications

Effect of veterinary feed directive rule changes on tetracycline-resistant and erythromycin-resistant bacteria (Salmonella, Escherichia, and Campylobacter) in retail meats in the United States

Effect of veterinary feed directive rule changes on tetracycline-resistant and erythromycin-resistant bacteria (Salmonella, Escherichia, and Campylobacter) in retail meats in the United States

Current status and trends in antimicrobial use in food animals in China, 2018–2020

Associations among antimicrobial use, calf management practices, and antimicrobial resistance in Escherichia coli from a pooled fecal sample in calves on Canadian dairy farms: A cross-sectional study

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