“…When embolism reaches clinically relevant levels, the most commonly observed symptoms are hypoxemia, shortness of breath, petechial rash, or an altered mental status [1,5,20]. If fat embolism becomes life-threatening, it is classified as fat embolism syndrome (FES) [1,4,5,11,19,20]. Although FES is rare and the true incidence and mortality rates are unclear [13,20], reported incidences of FES range from 0.1% to 1% of all TKAs, and mortality rates vary from 5% to 20% of diagnosed cases despite supportive care with anticoagulation therapy and ventilatory support [1,20].…”