Intramedullary spinal cord metastases

Jellinger, K. A.; Kothbauer, P; Sunder-Plassmann, E.; Weiss, Raymond B.

doi:10.1007/bf00313146

Cited by 101 publications

(72 citation statements)

References 18 publications

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“…4 To date, colon carcinomarelated metastasis is extremely rare with only few cases reported in the literature. [4][5][6][7][8][9][10][11][12] We report on a patient with an intramedullary metastasis as first presentation of a colon carcinoma without intracranial involvement. Total resection of the tumor led the asymptomatic tumor to be diagnosed and brought the patient 2 months of useful life.…”

Section: Introductionmentioning

confidence: 99%

Intramedullary spinal cord tumor presenting as the initial manifestation of metastatic colon cancer: case report and review of the literature

et al. 2007

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Study design: Case reports and review of the literature. Objective: Intramedullary spinal cord metastases (ISCMs) are rare type of central nervous system (CNS) involvement of systemic malignant tumors. Since the advent of new neuroradiological techniques, their detection have become increasingly diagnosed in recent years and, although somewhat controversial, surgical treatment has been considered a valid option. Setting: Neurosurgical Clinic, Department of Clinic Neuroscience, University of Palermo, Italy. Method: The authors describe the case of a 61-year-old woman who was admitted presenting with progressive tetraplegia. Investigations revealed an intramedullary spinal cord lesion at the cervical level. Magnetic resonance imaging of the brain did not reveal other CNS metastatic lesions. Result: Patient underwent surgical treatment. The tumor was resected and the patient's neurologic deficits slowly improved. Histological examination of the lesion showed the typical features of a colon carcinoma metastasis. Patient was referred for proper oncological treatment but, unfortunately, she died of disseminated disease within 2 months. Conclusion: Although uncommon, spinal cord metastases should be considered in the differential diagnosis of ISCM in order to rationalize the decisional-making process and improve the quality of life for these patients.

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Section: Introductionmentioning

confidence: 99%

Intramedullary spinal cord tumor presenting as the initial manifestation of metastatic colon cancer: case report and review of the literature

et al. 2007

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“…One third of adult spinal cord tumors are intramedullary and rest are extramedullary. Of the tumors metastasizing to the spinal cord lung carcinoma is the most common accounting for 50% followed by breast carcinoma, Lymphoma, melanoma, colorectal carcinoma, Hodgkin disease, head and neck carcinoma and leukemia [5] [6]. Primary tumors less commonly reported to metastasize to spine include schwannoma, mesothelioma, merkel tumor, plasmacytoma, teratoma, as well as basal cell, parotid, nasopharyngeal, laryngeal, esophageal, gall bladder, pancreas, ovarian, endometrial, and urinary bladder tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Prognosis is uniformly poor with life expectancy of months as this represents an advanced stage of disease [6]. Prognosis is based on degree of deficit, duration of symptoms, type and location of tumor and degree of advancement of disease.…”

Section: Discussionmentioning

confidence: 99%

Multiple Spinal Intradural-Intramedullary Involvement by Metastatic Carcinoma with Neuroendocrine Differentiation with Occult Primary—An Unusual Case Report and Review of Literature

Gupta¹,

Sinha²

2016

OJPathology

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Although vertebral column is recognized as the most common site for bony metastasis in patient with systemic malignancy, intramedullary metastases to the spinal cord is infrequent. Between 5% -10% of cancer patients develop spinal metastasis during the course of their diseases. Intramedullary tumors are rare, comprising 3.5% of spinal metastasis. Most metastatic spinal lesions (70%) are found at the thoracic level, 20% in lumbar region and 10% in the cervical region. We report a rare biopsy proven case of intramedullary spinal metastatic carcinoma with neuroendocrine differentiation because of its unusual presentation, involving spine at multiple noncontiguous levels, which appeared as irregular small nodules on MRI. The primary tumor was most likely from occult primary in lung. Biopsy from the spinal lesion established the diagnosis of metastatic carcinoma with neuroendocrine differentiation. Therefore, in patients with spinal metastasis, a thorough work up is advised to evaluate primary site. This would help to delineate the nature and the extent of the systemic disease. We highlighted herein the clinical presentation, radiological findings particularly MRI and role of biopsy in the diagnosis and treatment of intramedullary spinal metastasis.

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“…8 It may show abnormal enhancement or nodularity of the leptomeninges or hydrocephalus. 9 It is also helpful in ruling out the presence of disc herniation as a cause of CES. Myelography is highly correlated with the clinical diagnosis of CES with no false negative results.…”

Section: Discussionmentioning

confidence: 99%

“…13 CES may be an isolated presentation of meningeal carcinomatosis. 9 The prognosis is poor. In a study by Nakagawa, 22 of 29 patients showed symptomatic improvement with intrathecal methotrexate alone or combined with cystosine arabinoside with or without radiation.…”

Section: Discussionmentioning

confidence: 99%