Intramolecular C–H⋯F hydrogen bonding-induced 1,2,3-triazole-based foldamers

Abstract

Intramolecular C–H⋯F hydrogen bonding has been utilized to induce 1,2,3-triazole oligomers to fold into stable artificial secondary structures.

Advancements in Aminofluorination of Alkenes and Alkynes: Convenient Access to β‐Fluoroamines

“…It should be noted that only N ‐aryl‐substituted amides are suitable for this reaction, whereas primary and N ‐alkyl‐substituted amides are inactive. Later, a similar strategy, but one in which silver catalyst was not required, was used for the azidofluorination of unactivated alkenes (Scheme ) 61…”

Transition-Metal-Free Fluoroarylation of Diazoacetamides: A Complementary Approach to 3-Fluorooxindoles

“…When Na 2 CO 3 (1.5 eq) was applied, we envisioned that the base could promote the transformation, 18 and fortunately, the yield of 2a was significantly improved to 72% (entry 2). With this result in hand, several bases were investigated, and NaOAc was determined to be the best with DCE as the solvent (entries [3][4][5][6]. Various solvents were screened (entries [7][8][9][10][11][12][13], and only inferior results were obtained.…”

Recent Advances in the One‐Step Synthesis of Distally Fluorinated Ketones

“…Inspired by the great success of radical‐mediated fluorination of unsaturated carbon–carbon bonds,– Duan and co‐workers developed a mild silver‐catalyzed decarboxylative acylfluorination of styrenes for the synthesis of β‐fluorinated 3‐aryl ketones (Scheme ) . In this reaction, both electron‐rich and electron‐deficient aryloxoacetic acids afford the desired products in moderate to good yields.…”