Intramolecular Dehydrogenative Coupling Approach to 2‐Oxindoles Using Fe(OAc)₂/NaI/Na₂S₂O₈

Abstract

Oxindole units are common structures that are featuring in natural products and drugs. A novel method for synthesizing 2‐oxindoles from 1,3‐dicarbonyl compounds based on ferrous salt and iodide catalyst was described. Using Fe(OAc)2/NaI/Na2S2O8, various 2‐alkyl‐3‐phenylamino‐3‐oxopropanoates, bearing fluoro, chloro, bromo, alkyl, alkoxy, trifluoromethyl, cyano etc. on the benzene ring were converted smoothly into 2‐oxindoles.

H2O2‐Mediated Synthesis of 1,2,4‐Thiadiazole Derivatives in Ethanol at Room Temperature

“…Dehydrogenation coupling reactions with hydrogen as the only by‐product [1] include intramolecular dehydrogenative coupling [1a–d] and cross‐dehydrogenative coupling [1e–h] . Such reactions are widely applied in the construction of C−C, [2] C−X (X=N, O, S), [3–5] and N−X (X=N, O, S) bonds [6–8] .…”

X‐ray spectral characteristics of typical clays in China and their application in clay classification

“…Based on the principal component analysis it was found that the origins of the clay samples can be classified according to the intrinsic relationships between the elements in the clay samples. Therefore, the K-means cluster analysis method [32][33][34][35] was used to conduct a cluster analysis of the samples from the four locations. The results are shown in Table 5.…”

Sodium Persulfate (Na2S2O8)

“…The reaction scalability was investigated and proved to be suitable for gramscale applications without a drop in yield. 10…”

“…The reaction scalability was investigated and proved to be suitable for gram-scale applications without a drop in yield. 10 (H) The amide functional group has a central importance in biologically active compounds. For this reason, straightforward methods to prepare this functionality are very desirable.…”