Intramolecular, Interrupted Homo‐Nazarov Cascade Biscyclizations to Angular (Hetero)Aryl‐Fused Polycycles

Abstract

Herein, a SnCl 4 -catalyzed intramolecular, interrupted homo-Nazarov cascade biscyclization to access angular (hetero)aryl-fused polycycles is reported. Subsequent decarboxylation of the readily enolizable products afforded the angular products in up to 71 % yield over two steps, with the trans-diastereomers as the major products. The cyclopropyl homo-Nazarov cyclization precursors were formed using a scalable and modular synthetic route that, ultimately, offers access to 6,