“…Thus, although p80HT has been previously reported to have acquired novel transcriptional activation properties not associated with p52 (Chang et al, 1995), it appears that the NFKB2 promoter is not itself activated by p80HT. In contrast, we observed that p100 NF-kB-2, previously reported to have`IkB-like' properties in inhibiting NF-kB-mediated transcriptional activation (Blank et al, 1991;Henkel et al, 1992;Mercurio et al, 1992;Naumann et al, 1993b;Rice et al, 1992;Scheinman et al, 1993), was also a potent inhibitor of both the P1 and P2 NFKB2 promoters. This led us to hypothesize that the constitutive, high levels of transcription of the NF-kB-2 promoter could be due to the loss of p100 inhibitory activity, rather than due to a gain of function due to the generation of the p80HT protein.…”