Intramolecular sensitisation of lanthanide(iii) luminescence by acetophenone-containing ligands: the critical effect of para-substituents and solvent

Beeby, Andrew; Bushby, Lisa M.; Maffeo, Davide; Williams, J. A. Gareth

doi:10.1039/b105966c

Cited by 114 publications

(115 citation statements)

References 18 publications

Supporting

Mentioning

113

Contrasting

Order By: Relevance

“…Mono-N-t-Boc-1,6-hexanediamine was prepared according to a literature method [24]. 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid (DO3A) was synthesized according to a literature method [25].…”

Section: Experimental Section Materialsmentioning

confidence: 99%

Noninvasive Visualization of in Vivo Drug Delivery of Poly(l-glutamic acid) Using Contrast-Enhanced MRI

Jeong

et al. 2006

Mol. Pharmaceutics

View full text Add to dashboard Cite

Biomedical imaging is valuable for non-invasive investigation of in vivo drug delivery with polymer conjugates. It can provide real-time information on pharmacokinetics, biodistribution and drug delivery efficiency of the conjugates. Non-invasive visualization of in vivo drug delivery of polymer conjugates with contrast enhanced magnetic resonance imaging (MRI) was studied with paramagnetically labeled poly(L-glutamic acid) in an animal tumor model. Poly(L-glutamic acid) is a biocompatible and biodegradable drug carrier for diagnostics and therapeutics. Poly(L-glutamic acid)-1,6-hexanediamine-(Gd-DO3A) conjugates with molecular weights of 87, 50 and 28 KDa and narrow molecular weight distributions were prepared and studied in mice bearing MDA-MB-231 human breast cancer xenografts. Contrast enhanced MRI resulted in real-time and three-dimensional visualization of blood circulation, pharmacokinetics, biodistribution and tumor accumulation of the conjugates, and the size effect on these pharmaceutics properties. The conjugate of 28 KDa rapidly cleared from the circulation and had a relatively lower tumor accumulation. The conjugates with higher molecular weights exhibited a more prolonged blood circulation and higher tumor accumulation. The difference between the conjugates of 87 and 50 KDa was not significant. Contrast enhanced MRI is effective for non-invasive real-time visualization of in vivo drug delivery of paramagnetically labeled polymer conjugates.

show abstract

Section: Experimental Section Materialsmentioning

confidence: 99%

Noninvasive Visualization of in Vivo Drug Delivery of Poly(l-glutamic acid) Using Contrast-Enhanced MRI

Jeong

et al. 2006

Mol. Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…PD-10 desalting columns were purchased from GE Life Science (Piscataway, NJ). DO3A-(acetic acid-1,6-hexadiamine monoamide) (DO3A-AHM) and poly-(L-glutamic acid) N-hydroxylsuccinimide active ester (PGA-OSu) were synthesized from PGA (M w = 87 kDa, M n = 67 kDa) as previously described (17,23).…”

Section: Methodsmentioning

confidence: 99%

Contrast-Enhanced MRI-Guided Photodynamic Cancer Therapy with a Pegylated Bifunctional Polymer Conjugate

et al. 2008

View full text Add to dashboard Cite

Purpose-To study contrast-enhanced MRI guided photodynamic therapy with a pegylated bifunctional polymer conjugate containing an MRI contrast agent and a photosensitizer for minimally invasive image-guided cancer treatment.Methods-Pegylated and non-pegylated poly-(L-glutamic acid) conjugates containing mesochlorin e 6 , a photosensitizer, and Gd(III)-DO3A, an MRI contrast agent, were synthesized. The effect of pegylation on the biodistribution and tumor targeting was non-invasively visualized in mice bearing MDA-MB-231 tumor xenografts with MRI. MRI-guided photodynamic therapy was carried out in the tumor bearing mice. Tumor response to photodynamic therapy was evaluated by dynamic contrast enhanced MRI and histological analysis.Results-The pegylated conjugate had longer blood circulation, lower liver uptake and higher tumor accumulation than the non-pegylated conjugate as shown by MRI. Site-directed laser irradiation of tumors resulted in higher therapeutic efficacy for the pegylated conjugate than the nonpegylated conjugate. Moreover, animals treated with photodynamic therapy showed reduced vascular permeability on DCE-MRI and decreased microvessel density in histological analysis.Conclusions-Pegylation of the polymer bifunctional conjugates reduced non-specific liver uptake and increased tumor uptake, resulting in significant tumor contrast enhancement and high therapeutic efficacy. The pegylated poly(L-glutamic acid) bifunctional conjugate is promising for contrast enhanced MRI guided photodynamic therapy in cancer treatment.

show abstract

“…3 reveals that the predominant species in solution with the PYZ 2− ligand at these concentrations are in fact the ML 2 and ML complexes, with less than 1% of the intact ML 3 complex remaining. Due to the presence of inner-sphere water molecules on these hydrolyzed complexes, which have a well-known 33 quenching effect via non-radiative relaxation processes, the metal-centered luminescence is significantly reduced. Indeed, even in significantly more concentrated solutions, partial dissociation of the ML 3 complex will inevitably reduce the overall luminescence intensity compared to Eu(III) complexes with DPA 2− , which makes a direct comparison of the sensitisation efficiencies with these differing organic ligands problematic in aqueous solution.…”

Section: Aqueous Stability and Photophysicsmentioning

confidence: 99%

A comparison of sensitized Ln(iii) emission using pyridine- and pyrazine-2,6-dicarboxylates

Moore

2012

Dalton Trans.

View full text Add to dashboard Cite

The synthesis, X-ray structure, solution stability, and photophysical properties of Eu(III) complexes with pyrazine-2,6-dicarboxylic acid (H 2 PYZ) are reported, and compared to structurally analogous complexes with pyridine-2,6-dicarboxylic acid (H 2 DPA). The [Eu(PYZ) 3 ] 3− complex demonstrates highly efficient metal-centered Eu(III) luminescence in the solid state (Φ total ∼ 60.9%). In aqueous solution, moderate stability is retained at pH 7.4 ( pEu ∼ 10.5), although hydrolysis of the complex anion becomes competitive below mM concentrations, and the observed luminescence intensity from the Eu(III) metal ion is reduced as a result. A complete evaluation of the thermodynamic solution stability has allowed the observed differences in the solution behaviour luminescence properties of these complexes to be rationalized. An analysis of their luminescence behaviour in the solid state has also allowed a direct comparison of the sensitisation behaviour for these isostructural compounds.

show abstract

Intramolecular sensitisation of lanthanide(iii) luminescence by acetophenone-containing ligands: the critical effect of para-substituents and solvent

Cited by 114 publications

References 18 publications

Noninvasive Visualization of in Vivo Drug Delivery of Poly(l-glutamic acid) Using Contrast-Enhanced MRI

Noninvasive Visualization of in Vivo Drug Delivery of Poly(l-glutamic acid) Using Contrast-Enhanced MRI

Contrast-Enhanced MRI-Guided Photodynamic Cancer Therapy with a Pegylated Bifunctional Polymer Conjugate

A comparison of sensitized Ln(iii) emission using pyridine- and pyrazine-2,6-dicarboxylates

Contact Info

Product

Resources

About