2002
DOI: 10.1016/s1567-5769(02)00167-4
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Intramolecular signal transduction by the bradykinin B2 receptor

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Cited by 3 publications
(3 citation statements)
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“…Subconfluent cells were transfected in 24-well plates with BKR-B 2 -cDNA (1 g cDNA/well) by the DEAE-dextran technique, and cells were used 48-72 h after transfection. Preparation of COS-7 membranes was done as described previously [57].…”
Section: Cell Culture and Transfection Of Cos-7 Cellsmentioning
confidence: 99%
See 1 more Smart Citation
“…Subconfluent cells were transfected in 24-well plates with BKR-B 2 -cDNA (1 g cDNA/well) by the DEAE-dextran technique, and cells were used 48-72 h after transfection. Preparation of COS-7 membranes was done as described previously [57].…”
Section: Cell Culture and Transfection Of Cos-7 Cellsmentioning
confidence: 99%
“…COS-7 cells were transfected and labeled with 0.4 Ci/ml [ 3 H]arachidonic acid (60-100 Ci/mmol, NEN Life Science Products, USA) for 24 h as described previously [57]. The cells were washed three times with label-free DMEM containing 0.5% (v/v) fetal calf serum and then stimulated in 0.5 ml in the same medium with 3 × 10 −8 M BK for 30 min in the absence or the presence of J526 (0.1 M) or J527 (0.1 M) at 37 • C. Assays were terminated by removing the medium from the cells.…”
Section: Arachidonic Acid Releasementioning
confidence: 99%
“…Se, por um lado, os resultados apresentados por Ianzer et al 2007 reduzem a importância da inibição da formação da A-II no efeito antihipertensivo dos BPPs, por outro lado, eles não excluem a importância da potenciação dos efeitos da Bk. A hipótese de que não apenas os efeitos cardiovasculares dos BPPs (diminuição na freqüência cardíaca e diminuição da pressão arterial), como também outros efeitos envolvendo a intermediação de cininas, possam ser atribuídos ao efeito potenciador da Bk desses peptídeos, foi discutida por Marcic et al 2000e Mueller et al 2002. Essa hipótese, entretanto, não exclui a participação da sECA como enzima metabolizadora de cininas e como enzima envolvida no processo de sinalização mediada pelos receptores B1 e B2.…”
Section: Contexto Histórico Dos Peptídeos Potenciadores Da Bradicininunclassified