Published data on the synthesis and propera 'es of S-, 0-, and N-allyl derivatives of aromatic azines are classified and reviewed.
SYNTHESIS OF S-ALLYL DERIVATIVESAs a rule, allyithioazines are obtained by the reaction of mercaptoazines or metal thiolates with allyl halides in organic solvents. The following compounds of the pyridine series were obtained in this way: 2-Allylthiopyridine [1-3]; 2-allylthio-3-hydroxy-6-methylpyridines [4, 5]; 2-allylthio-6-methyl(aryl)-3-cyano(carboxy)pyridines [6-9]; 6-(1-adamantyl)-3-cyano-2-allylthiopyridine 2-Allylthiopyridine was obtained by the reaction of S-allylisothiuronium bromide with 2-bromopyridine [1] and by the reaction of allyl bromide with 2-pyridineisothiuronium halide [22, 42].The reaction of ethyl 5-amino-2-allylthio-7-methylthiothieno[2,3-d]pyrimidine-6-carboxylate with aUyl isocyanate gave 3-allyl-2-allylthio-7-methylthiothieno[2,3-d;4,5-d']
NH 2 MeS~JN ~CO2Ets--/-MeS 3-AIiylthio-l,2,4-triazines were obtained by the reaction of S-allylthiosemicarbazide hydrobromide with glyoxal and phenylglyoxal [44].