Introduction: Duodenal intramural hematoma is a rare consequence of pancreatitis, which occurs with obstruction of the duodenum, and may evolve with rupture of the organ. Case report: 47year-old male presenting abdominal pain and several episodes of vomiting. The upper gastrointestinal endoscopy and abdominal tomography confirmed the presence of duodenal intramural hematoma and pancreatitis. Conservative treatment was chosen, presenting a satisfactory response. However, it evolved with rupture of the hematoma and death. Discussion and Conclusion: duodenal intramural hematoma caused by pancreatitis is poorly reported in the literature, its treatment may be conservative or surgical, consideration should be given to the patient's clinical status and degree of duodenal involvement.