Intramuscular Chloroquine in Children

Trigg, P. I.; Wernsdorfer, Walther H.; Sheth, U K; Onori, E.

doi:10.1016/s0140-6736(84)90328-3

Cited by 8 publications

(1 citation statement)

References 2 publications

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“…to adults and children. Since in most countries in which this practice is common, adverse drug reactions are poorly monitored and records poorly kept it is not possible to estimate the danger to health or life that the practice constitutes and many authorities have accordingly advocated avoidance of this route as much as possible until further information is available (World Health Organisation, 1984, 1985Trigg et al, 1984). In the study reported here we administered 200 mg CQ i.m.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the pharmacokinetics of chloroquine after single intravenous and intramuscular administration in healthy Africans.

Aderounmu¹,

Salako²,

Lindström³

et al. 1986

Brit J Clinical Pharma

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The pharmacokinetics of chloroquine were studied after intramuscular and intravenous administration of the drug to healthy African adults. Chloroquine was analysed in plasma using an h.p.l.c. method and pharmacokinetic parameters were derived from the concentration‐time data using a non‐linear computer programme. A two‐compartment open model was assumed. Chloroquine was rapidly absorbed from an intramuscular site, producing a plasma concentration‐time profile similar to that obtained after a 15 min i.v. infusion of a comparable dose. The pharmacokinetics of chloroquine after i.m. and i.v. administration were characterised by a long half‐life and a very large volume of distribution. There was no significant difference between the values of each parameter obtained from the different routes. It is suggested that the high Cmax obtained after i.m. and i.v. administration of chloroquine might contribute to its toxicity when these routes are used in treatment.

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Section: Discussionmentioning

confidence: 99%

Comparison of the pharmacokinetics of chloroquine after single intravenous and intramuscular administration in healthy Africans.

Aderounmu¹,

Salako²,

Lindström³

et al. 1986

Brit J Clinical Pharma

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Chloroquine administration for malaria suppression after abdominal surgery

Schweizer

Stahel

Betschart

et al. 1987

Journal of British Surgery

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Administration of chloroquine after major surgery is indicated in malaria endemic areas. In emergencies it is commonly administered parenterally after the operation. The present study, undertaken at St. Francis Hospital, Ifakara (Kilombero District), Tanzania, compared plasma chloroquine levels after oral and subcutaneous administration of 300 mg of chloroquine base in 14 patients after abdominal, non-bowel-resective surgery and in 12 controls. There were no significant differences in the plasma chloroquine levels of all groups, and the chloroquine concentrations reached suppressive levels for at least 3 days (greater than 0.1 nmol/ml). Oral administration was well tolerated in both patients and controls. In all areas where the Plasmodium strains are still sensitive to chloroquine and where parenteral chloroquine may not be easily available, oral chloroquine represents a cheap, easy and safe alternative for postoperative prophylactic malaria suppression. It can be applied after abdominal non-bowel-resective emergency surgery.

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Drug use before hospital admission in Zimbabwe

Taylor

Jongeling

1988

Eur J Clin Pharmacol

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Drug use before hospital admission was studied prospectively in 284 consecutive patients admitted to general medical wards in Zimbabwe. Drugs were used by 84% of patients. Self-medication was used by 143 (50%) patients, aspirin (54%) and chloroquine (17%) being the most commonly used drugs. Traditional medicines were used by 55 (19%) patients. Drugs dispensed from orthodox medical sources were taken by 128 (45%) patients. Analgesics (22%), antibiotics (18%), and chloroquine (13%) were the commonest drugs dispensed. Urine screening tests were performed and were positive for aspirin in 37% of cases, chloroquine (33%), and antibiotics (20%). Adverse drug reactions requiring hospital admission occurred in 14 patients (10 orthodox medicines, 4 traditional medicines). Drug use before hospital admission, which is often poorly documented, is a source of potential drug toxicity and may obscure a diagnosis of infective illness.

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Intramuscular Chloroquine in Children

Cited by 8 publications

References 2 publications

Comparison of the pharmacokinetics of chloroquine after single intravenous and intramuscular administration in healthy Africans.

Comparison of the pharmacokinetics of chloroquine after single intravenous and intramuscular administration in healthy Africans.

Chloroquine administration for malaria suppression after abdominal surgery

Drug use before hospital admission in Zimbabwe

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