Intramuscular Fat Accumulation and Associations With Body Composition, Strength, and Physical Functioning in Patients With Rheumatoid Arthritis

Baker, Joshua F.; Mostoufi‐Moab, Sogol; Long, Jin; Zemel, Babette S.; Ibrahim, Said A.; Taratuta, Elena; Leonard, Mary B.

doi:10.1002/acr.23550

Cited by 32 publications

(30 citation statements)

References 45 publications

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“…2). Interestingly, intramuscular fat accumulation was recently reported to be associated with decline in skeletal muscle mass in aged subjects and patients with rheumatoid arthritis [35,36]. Of course, we cannot rule out such possibility that not only metabolic factors examined so far but also other humoral factors, e.g., pituitary hormones, influence on the alteration in the body composition and metabolism in corticosterone-treated mice.…”

Section: Discussionmentioning

confidence: 83%

Correlation among body composition and metabolic regulation in a male mouse model of Cushing’s syndrome

et al. 2020

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Glucocorticoids play a critical role in the regulation of homeostasis, including metabolism. In patients with Cushing's syndrome, chronic glucocorticoid excess disrupts physiological internal milieu, resulting in central obesity, muscle atrophy, fatty liver, and insulin resistance. However, the relationship among various metabolic effects of glucocorticoids remains unknown. In the present study, we studied a male mouse model of Cushing ' s syndrome and indicated that glucocorticoid excess alters metabolic phenotype and body composition involving possible communication among skeletal muscle, liver, and adipose tissue.

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Section: Discussionmentioning

confidence: 83%

Correlation among body composition and metabolic regulation in a male mouse model of Cushing’s syndrome

et al. 2020

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“…The increased accumulation of toxic lipid mediators and consequent lipotoxicity in skeletal muscles may also stimulate mitochondrial dysfunction, that, together with insulin resistance, contribute to cardiovascular disorders and sarcopenia [ 29 ]. Insulin resistance, cardiovascular disorders, and sarcopenia, associated with an increased intramuscular fat compared to healthy subjects, are frequently associated with RA [ 30 ].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations

et al. 2021

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Rheumatoid arthritis (RA) is a highly debilitating chronic inflammatory autoimmune disease most prevalent in women. The true etiology of this disease is complex, multifactorial, and is yet to be completely elucidated. However, oxidative stress and lipid peroxidation are associated with the development and pathogenesis of RA. In this case, oxidative damage biomarkers have been found to be significantly higher in RA patients, associated with the oxidation of biomolecules and the stimulation of inflammatory responses. Lipid peroxidation is one of the major consequences of oxidative stress, with the formation of deleterious lipid hydroperoxides and electrophilic reactive lipid species. Additionally, changes in the lipoprotein profile seem to be common in RA, contributing to cardiovascular diseases and a chronic inflammatory environment. Nevertheless, changes in the lipid profile at a molecular level in RA are still poorly understood. Therefore, the goal of this review was to gather all the information regarding lipid alterations in RA analyzed by mass spectrometry. Studies on the variation of lipid profile in RA using lipidomics showed that fatty acid and phospholipid metabolisms, especially in phosphatidylcholine and phosphatidylethanolamine, are affected in this disease. These promising results could lead to the discovery of new diagnostic lipid biomarkers for early diagnosis of RA and targets for personalized medicine.

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“…Alterations in muscle density, ectopic fat accumulation were also observed during sarcopenic obesity [28][29][30]. These abnormalities contribute to the alteration of muscle performances, inducing frailty and disability in RA patients, which, in turn, exacerbate muscle loss and fat deposition [4,31,32]. Moreover, epicardial adipose tissue is increased in RA and produces pro-inflammatory cytokines responsible of an early alteration of myocardial functions, thus leading to an increased risk of CVD [33,34].…”

Section: Cardiometabolic Comorbidities In Ramentioning

confidence: 99%

“…RA patients have a greater cardiovascular (CV) risk, more metabolic disorders such as insulin resistance and sarcopenia associated to increased intramuscular fat in comparison to healthy subjects [4]. An accumulation of scientific evidences suggests that diet could play a role in the prevention of this chronic disease.…”

Section: Introductionmentioning

confidence: 99%

Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?

2020

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Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by a high prevalence of death due to cardiometabolic diseases. As observed during the aging process, several comorbidities, such as cardiovascular disorders (CVD), insulin resistance, metabolic syndrome and sarcopenia, are frequently associated to RA. These abnormalities could be closely linked to alterations in lipid metabolism. Indeed, RA patients exhibit a lipid paradox, defined by reduced levels of total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol whereas the CVD risk is increased. Moreover, the accumulation of toxic lipid mediators (i.e., lipotoxicity) in skeletal muscles can induce mitochondrial dysfunctions and insulin resistance, which are both crucial determinants of CVD and sarcopenia. The prevention or reversion of these biological perturbations in RA patients could contribute to the maintenance of muscle health and thus be protective against the increased risk for cardiometabolic diseases, dysmobility and mortality. Yet, several studies have shown that omega 3 fatty acids (FA) could prevent the development of RA, improve muscle metabolism and limit muscle atrophy in obese and insulin-resistant subjects. Thereby, dietary supplementation with omega 3 FA should be a promising strategy to counteract muscle lipotoxicity and for the prevention of comorbidities in RA patients.

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Intramuscular Fat Accumulation and Associations With Body Composition, Strength, and Physical Functioning in Patients With Rheumatoid Arthritis

Abstract: The low muscle density observed in patients with RA was associated with low muscle mass, excess adiposity, poor strength, and greater disability. Interventions to address poor muscle quality could potentially affect important functional outcomes.

Cited by 32 publications

References 45 publications

Correlation among body composition and metabolic regulation in a male mouse model of Cushing’s syndrome

Correlation among body composition and metabolic regulation in a male mouse model of Cushing’s syndrome

Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations

Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?

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