Bleeding in COVID-19 severe pneumonia: The other side of abnormal coagulation pattern?To the Editor A novel coronavirus (SARS CoV-2) spread in China in December 2019, becoming soon a relevant problem of international public health concern [1]. In Italy the SARS-CoV-2 officially spread around the 20th of February 2020 and the country became the first in Europe to register a high number of infections and deaths. The beta-coronavirus mainly creates a severe acute respiratory syndrome (COVID-19), with fever, cough, fatigue, pneumonia and acute respiratory distress syndrome, eventually. The patient management mainly focuses on supportive care: oxygenation, fluid management, and treatments with multiple drugs as antiviral therapies, chloroquine or hydroxyichloroquine, antibiotics, steroids, nonsteroidal anti-inflammatory drugs, bronchodilators and immunosuppressive drugs. Many patients require invasive ventilation, whereas others are treated with non-invasive ventilation (NIV) support or C-PAP (Continuous Positive Airway Pressure). In the available studies, COVID-19 patients showed alterations of coagulation test, with significant increase of D-Dimer levels associated with severity of illness and adverse outcomes [2]. Besides, a high risk for venous thromboembolism has been recently highlighted with high prevalence of symptomatic acute pulmonary embolism and deep vein thrombosis in patients [3]. Therefore, currently low molecular weight heparin (LMWH) has become part of the clinical management of the hospitalized COVID-19 patients, even if evidences about the right prophylactic dose are still lacking. In this scenario, we describe two cases of spontaneous abdominal internal bleeding in hospitalized patients with bilateral interstitial pneumonia and SARS-CoV-2 throat swab positive, supported with C-PAP ventilation, as the invasive ventilation was not recommended for both.The first patient, a 76-year-old man, was supported with C-PAP helmet, with PEEP 12.5 and FiO2 50%. The comorbidity were arterial hypertension and chronic ischemic heart disease. He was treated with antiviral drugs, azythromicine, steroids and LMWH 6000 UI daily. Suddenly, after 7 days from the admission to the hospital, he started complaining of severe abdominal pain, the blood pressure decreased to 80/60 mmHg and the blood test showed Hb 8.6 g/dl (from 12 g/dl), fibrinogen of 324 mg/dl; normal protrombine time (PT) and platelet count (PTL). The abdominal CT scan demonstrated a large pelvic blood collection anterior to the left ileo-psoas muscle (size. 9×13 cm) (Fig. 1A). The lesion showed enhanced contrast tardive spot of 10 mm, above the ischiopubic branch, as sign of active arterial bleeding. The second case refers to a 72-year-old woman with severe respiratory insufficiency, treated with C-PAP helmet, PEEP 12 cm H2O, FiO2 60%. The comorbidities were arterial hypertension and anxious syndrome. During a sonography performed to place a CVC, a venous femoral thrombosis was detected; LMWH at therapeutic dose 100UI/kg/BID was promptly started. Suddenly, ...