Intramuscular hypoperfusion, adrenergic receptors, and chronic muscle pain

Maekawa, Kenji; Clark, Glenn T.; Kuboki, Takuo

doi:10.1054/jpai.2002.125923

Cited by 67 publications

(49 citation statements)

References 51 publications

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“…The neural control of muscular blood flow during exercise involves sympathetic nervous system and somatomotor interactions (Thomas and Segal 2004). Elevated sympathetic activity or diminished sensitivity of b-adrenergic receptors may result in altered blood flow due to imbalance between vasoconstriction and dilatation in the affected muscle (Maekawa et al 2002;Passatore and Roatta 2003).…”

Section: Blood Flowmentioning

confidence: 99%

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Effects of static contraction and cold stimulation on cardiovascular autonomic indices, trapezius blood flow and muscle activity in chronic neck–shoulder pain

et al. 2011

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The aim of the present study was to investigate reactions in trapezius muscle blood flow (MBF), muscle activity, heart rate variability (HRV) and systemic blood pressure (BP) to autonomic tests in subjects with chronic neck-shoulder pain and healthy controls. Changes in muscle activity and blood flow due to stress and unfavourable muscle loads are known underlying factors of work-related muscle pain. Aberration of the autonomic nervous system (ANS) is considered a possible mechanism. In the present study, participants (n = 23 Pain, n = 22 Control) performed autonomic tests which included a resting condition, static hand grip test (HGT) at 30% of maximal voluntary contraction, a cold pressor test (CPT) and a deep breathing test (DBT). HRV was analysed in time and frequency domains. MBF and muscle activity were recorded from the upper trapezius muscles using photoplethysmography and electromyography (EMG). The pain group showed reduced low frequency-HRV (LF) and SDNN during rest, as well as a blunted BP response and increased LF-HRV during HGT (∆systolic 22 mm Hg; ∆LF(nu) 27%) compared with controls (∆systolic 27; ∆LF(nu) 6%). Locally, the pain group had attenuated trapezius MBF in response to HGT (Pain 122% Control 140%) with elevated trapezius EMG following HGT and during CPT. In conclusion, only HGT showed differences between groups in systemic BP and HRV and alterations in local trapezius MBF and EMG in the pain group. Findings support the hypothesis of ANS involvement at systemic and local levels in chronic neck-shoulder pain.

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Section: Blood Flowmentioning

confidence: 99%

“…A possible mechanism seems to be aberration in the autonomic nervous system (ANS) (Maekawa et al 2002;Passatore and Roatta 2006). In chronic muscle pain, sympathetic activity due to nociceptive stimulation may cause disturbances of blood flow regulation in the affected muscle and enhance muscle activation.…”

Section: Introductionmentioning

confidence: 99%

Effects of static contraction and cold stimulation on cardiovascular autonomic indices, trapezius blood flow and muscle activity in chronic neck–shoulder pain

et al. 2011

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“…The autonomic nervous system (ANS) is an important factor in pathogenesis of chronic muscle pain (Passatore & Roatta 2006;Johansson et al 2003;Maekawa et al 2002). Elevated sympathetic activity may alter pain perception/sensitivity by increasing muscle tension (Roatta et al 2008;Larsman et al 2009) and impairing local microcirculation in the affected muscle (Larsson 1995).…”

Section: Introductionmentioning

confidence: 99%

Effects of Heart Rate Variability Biofeedback in Subjects with Stress-Related Chronic Neck Pain: A Pilot Study

Hallman

Olsson

Schéele

et al. 2011

Appl Psychophysiol Biofeedback

123

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Recent studies focusing on autonomic nervous system (ANS) dysfunctions, together with theoretical pathophysiological models of musculoskeletal disorders, indicate the involvement of ANS regulation in development and maintenance of chronic muscle pain. Research has demonstrated the effectiveness of heart rate variability (HRV) biofeedback (BF) in increasing HRV and reducing the symptoms of different disorders characterized by ANS aberration. The study investigated the effects of resonance frequency HRV BF on autonomic regulation and perceived health, pain, stress and disability in 24 subjects with stress-related chronic neckshoulder pain. Twelve subjects participated in 10 weekly sessions of resonant HRV BF and were compared to a control group. Subjective reports and HRV measures during relaxation and in response to a standardized stress protocol were assessed for both groups pre-and postintervention. Group X time interactions revealed a significantly stronger increase over time in perceived health (SF-36) for the treatment group, including vitality, bodily pain and social functioning. Interactions were also seen for HRV during relaxation and reactivity to stress.The present pilot study indicates improvement in perceived health over a 10 week intervention with HRV-biofeedback in subjects with chronic neck-pain. Increased resting HRV as well as enhanced reactivity to hand grip and cold pressor tests might reflect beneficial effects on ANS regulation, and suggest that this intervention protocol is suitable for a larger controlled trial.

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“…Disturbance of the hemodynamics of the jaw muscles is prevalent in individuals with a history of orofacial dysfunction associated with chronic orofacial pain, such as temporomandibular disorders and fibromyalgia (5,6,19,21). For example, individuals with a history of chronic jaw muscle pain have slow intramuscular reperfusion during the recovery phase after sustained isometric contractions (6).…”

mentioning

confidence: 99%

GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle

Ishii

Izumi

2012

American Journal of Physiology-Regulatory, Integrative and Comp

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Ishii H, Izumi H. GABAB receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle. Am J Physiol Regul Integr Comp Physiol 302: R776 -R784, 2012. First published January 4, 2012; doi:10.1152/ajpregu.00569.2011.-The present study was designed to examine whether trigeminal nociceptive inputs are involved in the modulation of parasympathetic reflex vasodilation in the jaw muscles. This was accomplished by investigating the effects of noxious stimulation to the orofacial area with capsaicin, and by microinjecting GABA A and GABAB receptor agonists or antagonists into the nucleus of the solitary tract (NTS), on masseter hemodynamics in urethane-anesthetized rats. Electrical stimulation of the central cut end of the cervical vagus nerve (cVN) in sympathectomized animals bilaterally increased blood flow in the masseter muscle (MBF). Increases in MBF evoked by cVN stimulation were markedly reduced following injection of capsaicin into the anterior tongue in the distribution of the lingual nerve or lower lip, but not when injected into the skin of the dorsum of the foot. Intravenous administration of either phentolamine or propranolol had no effect on the inhibitory effects of capsaicin injection on the increases of MBF evoked by cVN stimulation, which were largely abolished by microinjecting the GABA B receptor agonist baclofen into the NTS. Microinjection of the GABAB receptor antagonist CGP-35348 into the NTS markedly attenuated the capsaicin-induced inhibition of MBF increase evoked by cVN stimulation, while microinjection of the GABA A receptor antagonist bicuculline did not. Our results indicate that trigeminal nociceptive inputs inhibit vagal-parasympathetic reflex vasodilation in the masseter muscle and suggest that the activation of GABA B rather than GABA A receptors underlies the observed inhibition in the NTS.capsaicin; cervical vagus nerve; baclofen; bicuculline; CGP-35348

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Intramuscular hypoperfusion, adrenergic receptors, and chronic muscle pain

Cited by 67 publications

References 51 publications

Effects of static contraction and cold stimulation on cardiovascular autonomic indices, trapezius blood flow and muscle activity in chronic neck–shoulder pain

Effects of static contraction and cold stimulation on cardiovascular autonomic indices, trapezius blood flow and muscle activity in chronic neck–shoulder pain

Effects of Heart Rate Variability Biofeedback in Subjects with Stress-Related Chronic Neck Pain: A Pilot Study

GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle

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