Intramuscular injection of nerve growth factor as a model of temporomandibular disorder: nature, time-course, and sex differences characterising the pain experience

Schabrun, Siobhan M; Si, Emily; Millard, S.K.; Chiang, Alan; Chen, S.; Chowdhury, Nahian S.; Seminowicz, David A.

doi:10.1016/j.ynpai.2023.100117

Cited by 6 publications

(8 citation statements)

References 25 publications

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“…On Day 4, participants received the final session of rTMS, followed immediately by a repeat assessment of PAF and CME. Intramuscular injection of NGF was given into the right masseter muscle at the end of the Day 4 session to induce prolonged pain and dysfunction mimicking temporomandibular disorder (TMD) [89]. From Days 5-25, participants completed twice daily electronic dairies comprising measures of pain and function.…”

Section: Methodsmentioning

confidence: 99%

“…Pain upon functional jaw movement is a key criterion for the diagnosis of TMD [91]. Moreover, previous research has shown that, after an NGF injection to the masseter muscle, pain during chewing and yawning activities are higher compared to other activities [23;89]. As such, our primary outcomes were pain upon chewing and yawning.…”

Section: Methodsmentioning

confidence: 99%

“…In contrast, the NGF paradigm is one of few experimental pain paradigms that can produce a prolonged pain experience in humans lasting several weeks [8]. Several studies have shown that injecting NGF to the neck, forearm or masseter muscles can mimic symptoms of clinical neck pain [21], lateral epicondylalgia (tennis elbow) [8] and TMD [89] respectively, including the time course (gradual onset and prolonged duration), movement-evoked pain, impaired joint movements, limited function and hyperalgesia (lower pressure pain thresholds).…”

Section: Rtms Delivered Prior To a Prolonged Pain Episode Protects Ag...mentioning

confidence: 99%

“…Several studies demonstrated that a single session of high frequency rTMS [9;61;69;70;117] delivered within an hour before transient pain led to reduced pain sensitivity and severity in pain-free individuals. However, no study has explored these effects using a prolonged pain model, such as pain induced by intramuscular injections of nerve growth factor (NGF) [45;89]. This is a critical question, as interventions that can ameliorate future prolonged pain might also be effective in hindering the transition from acute to chronic pain.…”

mentioning

confidence: 99%

“…This is a critical question, as interventions that can ameliorate future prolonged pain might also be effective in hindering the transition from acute to chronic pain. NGF injections induce prolonged musculoskeletal pain [17] that mimics the duration, time course, functional limitation and hyperalgesia associated with chronic pain conditions [8;89]. This makes the NGF model a highly standardised and clinically relevant model for exploring the prophylactic effects of rTMS on a future prolonged pain episode.…”

mentioning

confidence: 99%

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A 5-day course of rTMS before pain onset ameliorates future pain and increases sensorimotor peak alpha frequency

Chowdhury,

Taseen,

Chiang

et al. 2024

Preprint

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Repetitive transcranial magnetic stimulation (rTMS) has shown promise as an intervention for pain. An unexplored research question is whether the delivery of rTMSprior to pain onsetmight protect against a future episode of prolonged pain. The present study aimed to determine i) whether 5 consecutive days of rTMS delivered prior to experimentally-induced prolonged jaw pain could reduce future pain intensity and ii) whether any effects of rTMS on pain were mediated by changes in corticomotor excitability (CME) and/or sensorimotor peak alpha frequency (PAF). On each day from Day 0-4, forty healthy individuals received a single session of active (n = 21) or sham (n = 19) rTMS over the left primary motor cortex. PAF and CME were assessed on Day 0 (before rTMS) and Day 4 (after rTMS). Prolonged pain was induced via intramuscular injection of nerve growth factor (NGF) in the right masseter muscle after the final rTMS session. From Days 5-25, participants completed twice-daily electronic dairies including pain on chewing and yawning (primary outcomes), as well as pain during other activities (e.g. talking), functional limitation in jaw function and muscle soreness (secondary outcomes). Compared to sham, individuals who received active rTMS subsequently experienced lower pain on chewing and yawning. Although active rTMS increased PAF, the effects of rTMS on pain were not mediated by changes in PAF or CME. This study is the first to show that rTMS deliveredpriorto pain onset can protect against future pain and associated functional impairment. Thus, rTMS may hold promise as a prophylactic intervention for persistent pain.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Rtms Delivered Prior To a Prolonged Pain Episode Protects Ag...mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

A 5-day course of rTMS before pain onset ameliorates future pain and increases sensorimotor peak alpha frequency

Chowdhury,

Taseen,

Chiang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

The influence of threat on visuospatial perception, affordances, and protective behaviour: A systematic review and meta-analysis

MacIntyre,

Pinto,

Mouatt

et al. 2024

Clinical Psychology Review

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A 5-day course of repetitive transcranial magnetic stimulation before pain onset ameliorates future pain and increases sensorimotor peak alpha frequency

Chowdhury,

Taseen,

Chiang

et al. 2024

Pain

View full text Add to dashboard Cite

Repetitive transcranial magnetic stimulation (rTMS) has shown promise as an intervention for pain. An unexplored research question is whether the delivery of rTMS prior to pain onset might protect against a future episode of prolonged pain. The present study aimed to determine whether (1) 5 consecutive days of rTMS delivered prior to experimentally induced prolonged jaw pain has a prophylactic effect on future pain intensity and (2) whether these effects were accompanied by increases in corticomotor excitability (CME) and/or sensorimotor peak alpha frequency (PAF). On each day from day 0 to 4, 40 healthy individuals received a single session of active (n = 21) or sham (n = 19) rTMS over the left primary motor cortex. Peak alpha frequency and CME were assessed on day 0 (before rTMS) and day 4 (after rTMS). Prolonged pain was induced via intramuscular injection of nerve growth factor in the right masseter muscle after the final rTMS session. From days 5 to 25, participants completed twice-daily electronic diaries including pain on chewing and yawning (primary outcomes), as well as pain during other activities (eg, talking), functional limitation in jaw function and muscle soreness (secondary outcomes). Compared to sham, individuals who received active rTMS subsequently experienced lower pain on chewing and yawning. Furthermore, active rTMS led to an increase in PAF. This is the first study to show that rTMS delivered prior to prolonged pain onset can protect against future pain. Our findings suggest that rTMS may hold promise as a prophylactic intervention for pain.

show abstract

Intramuscular injection of nerve growth factor as a model of temporomandibular disorder: nature, time-course, and sex differences characterising the pain experience

Cited by 6 publications

References 25 publications

A 5-day course of rTMS before pain onset ameliorates future pain and increases sensorimotor peak alpha frequency

A 5-day course of rTMS before pain onset ameliorates future pain and increases sensorimotor peak alpha frequency

The influence of threat on visuospatial perception, affordances, and protective behaviour: A systematic review and meta-analysis

A 5-day course of repetitive transcranial magnetic stimulation before pain onset ameliorates future pain and increases sensorimotor peak alpha frequency

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