Intramuscular peripheral nerve sheath tumors: schwannoma, ancient schwannoma, and neurofibroma

Lee, Seul Ki; Kim, Jee Young; Lee, Yeonsoo; Jeong, Hyang Sook

doi:10.1007/s00256-020-03371-6

Cited by 21 publications

(22 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The case listed “contiguity of the tumor with the nerve of origin” as one of the signs clearly observed on US. A recent study by Lee et al (27) using MRI examination reported “entering and exiting nerves” as one of the distinguishing features, observed in 70.8% of intramuscular schwannomas, while none were observed in neurofibroma. We observed bilateral entering/exiting nerve in majority of schwannoma cases (73.0%) and in only one case of other lesions (but not neurofibroma).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma

et al. 2022

View full text Add to dashboard Cite

Background Ultrasound (US) diagnostic techniques have the advantages of low cost, convenient operation, and high availability. Purpose To explore the diagnostic accuracy of multiparametric US in evaluating signs of peripheral schwannoma. Material and Methods This retrospective case-control study included patients with soft-tissue masses on the limbs (divided into the schwannoma and non-schwannoma groups) between January 2017 and November 2020. US features were compared between the two groups, and receiver operating characteristics analysis was used to evaluate the diagnostic efficacy of these features. Results A total of 165 patients were included in this study; of them, 63 (38.2%) were diagnosed with schwannoma. Regular morphology (95.2% vs. 39.2%), cystic degeneration (71.4% vs. 27.5%), target sign on elastography (82.5% vs. 0), and polar blood supply sign (87.3% vs. 14.7%) were more common in schwannomas than in non-schwannoma lesions (all P < 0.001). Combining the four signs for diagnosis of schwannomas, the sensitivity, specificity, and accuracy were 95.24%, 96.08%, and 95.76%, respectively, with an area under the curve (AUC) of 0.987 (95% confidence interval = 0.955–0.998). Entering and exiting nerve sign was observed in 87.3% of schwannomas and in 3.0% of non-schwannoma lesions ( P < 0.001), while split-fat sign was similar between the two groups (9.5% vs. 2.0%; P = 0.068). Conclusion Polar blood supply sign and target sign on elastography are specific US signs in peripheral schwannomas. The combination of two-dimensional imaging, color flow imaging, and elastography can achieve an excellent diagnostic accuracy in schwannomas.

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The observed peripheral enhancement can be found in neurofibromas and even in schwannomas. 17,18 Nerve tractography and functional MRI can be valuable tools to differentiate between benign and malignant tumors of the peripheral nerves; however more studies are needed to elucidate this question. [19][20][21] Another aspect to be discussed is the surgical treatment performed.…”

Section: Discussionmentioning

confidence: 99%

Ewing Sarcoma in the Sciatic Nerve: Case Report

Marques¹,

Marques

2022

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

View full text Add to dashboard Cite

Ewing sarcoma (ES) is a malignant neoplasm that affects bones and soft tissues, usually in young patients. Currently, ES is grouped with other tumors that share the same histological and genotypic characteristics, forming the Ewing Sarcoma Family of Tumors (ESFT), which includes ES of bone, extraosseous ES (peripheral neuroepithelioma), Askin tumor, and peripheral primitive neuroectodermal tumor (PNET). Its origin in peripheral nerves is extremely rare, making its diagnosis and treatment very challenging. We describe a case of a 27-year-old male with extraosseous ES originating in the sciatic nerve, which was surgically removed, and discuss the difficulties encountered in the management of this patient.

show abstract

“…In our series, en bloc resection of neurofibromas arising from the intramuscular nerve did not cause persistent neurological deficits. A study reported that intramuscular peripheral nerve tumors were associated with denervation of the affected muscle [ 29 ]. The authors of the study observed a change in muscle denervation on the MRIs of some schwannomas (33.3%) and all ancient schwannomas (100.0%).…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment and Complications of Deep-Seated Nodular Plexiform Neurofibromas Associated with Neurofibromatosis Type 1

Ikuta

Nishida

Sakai

et al. 2022

JCM

View full text Add to dashboard Cite

Background: Nodular plexiform neurofibromas in individuals with neurofibromatosis type 1 often cause significant symptoms and are treated with surgical excision despite the potential risk of complications. This study aimed to clarify the surgical outcomes of deep-seated nodular plexiform neurofibromas and identify the factors associated with postoperative complications. Methods: We retrospectively reviewed patients with neurofibromatosis type 1 who underwent surgical excision for deep-seated nodular plexiform neurofibromas in our hospital from 2015 to 2021. Enucleation while preserving the nerve fascicles was attempted first, and en bloc resection, ligating the nerve origin in cases in which the parent nerve was entrapped by the tumor, making the tumor difficult to dissect, was performed. Results: In 15 patients, 24 nodular plexiform neurofibromas received surgical excision. Sixteen tumors were enucleated, and eight were en bloc resected. The symptoms of all 10 patients with preoperative symptoms resolved after surgery. Four patients developed new neurological deficits immediately after surgery, two of whom had retained neurological symptoms at the last visit, but these symptoms were mild. Conclusions: The present study demonstrates that surgical treatment of nodular plexiform neurofibromas, even deep-seated neurofibromas, is safe with a low risk of severe complications and improvement in preoperative symptoms.

show abstract

Intramuscular peripheral nerve sheath tumors: schwannoma, ancient schwannoma, and neurofibroma

Cited by 21 publications

References 18 publications

Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma

Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma

Ewing Sarcoma in the Sciatic Nerve: Case Report

Surgical Treatment and Complications of Deep-Seated Nodular Plexiform Neurofibromas Associated with Neurofibromatosis Type 1

Contact Info

Product

Resources

About