Intramuscular progesterone (IM-P4) administration is associated with better pregnancy rates in frozen-thawed blastocyst transfers, regardless of progesterone serum levels

Torelli, F.

doi:10.26226/morressier.573c1514d462b80296c98d52

Cited by 1 publication

(1 citation statement)

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“…However, some genes expression appeared multiphasic & dose-response dependant, suggesting constant supraphysiological doses of P maybe not optimal. A recent Cochrane trial in 2016 stated that serum P were affected by routes of administrations but not affected on EMT or CPR as both could similarly occurred across different P levels in medicated FET cycles which was consistent with our indings (Torelli et al, 2016). Lastly, (Polat et al, 2020) suggested that neither the serum P level nor the type of P administrations were independent predictors of Ong PR in FET cycles.…”

Section: Resultssupporting

confidence: 86%

Endometrial compaction and serum progesterone measurements at the day of embryo transfer cannot predict pregnancy outcomes in frozen-thaw embryo transfer cycles

Jarrah¹,

Al-Obaidi²,

Asadi³

2021

ijrps

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Endometrial receptivity plays a basic role in successful embryo implantation and pregnancy outcomes and can be assessed by many of non-invasive markers. Our study evaluated the impact of two of these markers specifically serum progesterone and endometrial thickness at embryo transfer day in prediction pregnancy outcomes on (60) patients attempting medicated frozen embryo transfer (FET) cycles. All patients were received sequential estrogen & progesterone medications for endometrial preparation then submitted to measurements of endometrial thickness (EMT) by transvaginal-ultrasound (TV-US) & serums progesterone (P) analysis at the embryo transfer day, thereafter day 3 verified-thawed embryos grades (A±B) were transferred. Compacted (decreased) EMT was seen in 48.3% of patients with higher pregnancy rate (PR) of 58.6%t than non-compacted EMT (no change or increased) which was seen in 51.7% of patients with (PR) of 29.0%, (P value=0.021). However ongoing pregnancy rate (Ong PR) not differed significantly between both groups (44.8% in compacted vs 25.8% in non-compacted, P value=0.053), also the means of serum P not differed between pregnant and non-pregnant patients (P value=0.374). ROC curves for Ong PR prediction in relations to endometrial compaction & serum progesterone at embryo transfer day were poor (AUC= 0.630, & AUC=0.576, respectively). This study suggested that endometrial compaction or serum P levels measurements at embryo transfer day were poor predictors for ongoing pregnancy where any kind of EMT changes (decreased or not) seen after P administration not significantly affect pregnancy outcomes in frozen-thaw cycles of cleavage stage embryos transfer.

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Section: Resultssupporting

confidence: 86%