Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain

Liu, Shanshan; Yang, Shan; Ho, Paul C.

doi:10.1016/j.ajps.2017.09.001

Cited by 167 publications

(73 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Liu et al [ 116 ] prepared nanoparticles of carboxymethyl chitosan for the release of intra-nasal carbamazepine (CBZ) to bypass the blood–brain barrier membrane, thus increasing the amount of the medication in the brain and refining the treatment efficacy, thereby reducing the systemic drug exposure. The nanoparticles had a mean diameter of 218.76 ± 2.41 nm, encapsulation efficiency of 80% and drug loading of 35%.…”

Section: Drug Designing and Drug Delivery Process And Mechanismmentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

View full text Add to dashboard Cite

Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.

show abstract

Section: Drug Designing and Drug Delivery Process And Mechanismmentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

View full text Add to dashboard Cite

show abstract

“…There are several mechanisms which govern drug release from chitosan nanoparticles such as: swelling of the polymer [25], diffusion of the adsorbed drug, drug diffusion through the polymeric matrix, polymer erosion or degradation and a combination of both erosion and degradation [26] as represented in Figure 3. The initial burst release from the chitosan nanoparticles is either because of swelling of the polymer, creating pores, or diffusion of the drug from the surface of the polymer [27].…”

Section: Drug Release From Chitosan Nanoparticlesmentioning

confidence: 99%

“…Carboxymethyl chitosan NPs of carbamazepine have found to enhance the bioavailability and brain targeting via the nasal route. The brain-to-plasma exposure ratio was 150% when carbamazepine was administered as chitosan NPs intranasally [25]. In Alzheimer’s disease (AD), a person’s sex is a risk factor and in women with AD, the levels of 17β-estradiol are found to be relatively low.…”

Section: Chitosan In Nasal Drug Deliverymentioning

confidence: 99%

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

et al. 2017

View full text Add to dashboard Cite

The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration. Chitosan has chemical functional groups that can be modified to achieve specific goals, making it a polymer with a tremendous range of potential applications. Nanoparticles (NP) prepared with chitosan and chitosan derivatives typically possess a positive surface charge and mucoadhesive properties such that can adhere to mucus membranes and release the drug payload in a sustained release manner. Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review. Chitosan shows low toxicity both in vitro and some in vivo models. This review explores recent research on chitosan based NP for non-parenteral drug delivery, chitosan properties, modification, toxicity, pharmacokinetics and preclinical studies.

show abstract

“…Other factors that influenced the high brain uptake of the drug are the use of mucoadhesive material in the formulation which extended the contact time of the formulation in the nasal mucosa. The encapsulation of drug into the nanoparticles enhanced the drug bioavailability and brain targeting by adhering to the mucosal surface, thereby improving the drug dissolution in the mucosa [76].…”

Section: Nanoparticles (Nps)mentioning

confidence: 99%

Chitosan-Based Nanocarriers for Nose to Brain Delivery

Aderibigbe

Naki

2019

Applied Sciences

View full text Add to dashboard Cite

In the treatment of brain diseases, most potent drugs that have been developed exhibit poor therapeutic outcomes resulting from the inability of a therapeutic amount of the drug to reach the brain. These drugs do not exhibit targeted drug delivery mechanisms, resulting in a high concentration of the drugs in vital organs leading to drug toxicity. Chitosan (CS) is a natural-based polymer. It has unique properties such as good biodegradability, biocompatibility, mucoadhesive properties, and it has been approved for biomedical applications. It has been used to develop nanocarriers for brain targeting via intranasal administration. Nanocarriers such as nanoparticles, in situ gels, nanoemulsions, and liposomes have been developed. In vitro and in vivo studies revealed that these nanocarriers exhibited enhanced drug uptake to the brain with reduced side effects resulting from the prolonged contact time of the nanocarriers with the nasal mucosa, the surface charge of the nanocarriers, the nano size of the nanocarriers, and their capability to stretch the tight junctions within the nasal mucosa. The aforementioned unique properties make chitosan a potential material for the development of nanocarriers for targeted drug delivery to the brain. This review will focus on chitosan-based carriers for brain targeting.

show abstract

Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain

Cited by 167 publications

References 30 publications

Nano based drug delivery systems: recent developments and future prospects

Nano based drug delivery systems: recent developments and future prospects

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

Chitosan-Based Nanocarriers for Nose to Brain Delivery

Contact Info

Product

Resources

About