Intranasal administration of neuromedin U derivatives containing cell-penetrating peptides and a penetration-accelerating sequence induced memory improvements in mice

Sasaki-Hamada, Sachie; Funane, Taichi; Nakao, Yusuke; Sasaki, Rie; Nagai, Mio; Ueta, Yudai; Yoshizawa, Kazumi; Horiguchi, Michiko; Yamashita, Chikamasa; Oka, Jun

doi:10.1016/j.peptides.2017.10.010

Cited by 15 publications

(22 citation statements)

References 32 publications

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“…Oxytocin/vasopressin-like neuropeptides have also been shown to regulate learning in C. elegans 60. Other neuropeptides that are involved in vertebrate and invertebrate learning include NPY/ NPF, neuromedin U and tachykinin 9,63,83,131,132. These neuropeptide families may be ancient regulators of learning circuits, although it remains to be determined whether the underlying neuromodulatory mechanisms are conserved between vertebrates and invertebrates.…”

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confidence: 99%

Neuromodulatory pathways in learning and memory: Lessons from invertebrates

Damme

Fruyt

Watteyne

et al. 2020

J Neuroendocrinology

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In an ever‐changing environment, animals have to continuously adapt their behaviour. The ability to learn from experience is crucial for animals to increase their chances of survival. It is therefore not surprising that learning and memory evolved early in evolution and are mediated by conserved molecular mechanisms. A broad range of neuromodulators, in particular monoamines and neuropeptides, have been found to influence learning and memory, although our knowledge on their modulatory functions in learning circuits remains fragmentary. Many neuromodulatory systems are evolutionarily ancient and well‐conserved between vertebrates and invertebrates. Here, we highlight general principles and mechanistic insights concerning the actions of monoamines and neuropeptides in learning circuits that have emerged from invertebrate studies. Diverse neuromodulators have been shown to influence learning and memory in invertebrates, which can have divergent or convergent actions at different spatiotemporal scales. In addition, neuromodulators can regulate learning dependent on internal and external states, such as food and social context. The strong conservation of neuromodulatory systems, the extensive toolkit and the compact learning circuits in invertebrate models make these powerful systems to further deepen our understanding of neuromodulatory pathways involved in learning and memory.

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mentioning

confidence: 99%

Neuromodulatory pathways in learning and memory: Lessons from invertebrates

Damme

Fruyt

Watteyne

et al. 2020

J Neuroendocrinology

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“…The NMU signaling system has an ancient role in energy homeostasis across vertebrates and insects [14][15][16][17][18] . Despite its wide distribution in brain regions responsible for learning and processing of aversive experiences 14,15 , only a few studies have postulated a role for mammalian NMU in memory based on its effects upon administration into the brain [20][21][22] . In Drosophila, the capa receptor gene is expressed in the mushroom bodies and neurons expressing the NMU precursor gene hugin are part of a sensory pathway that relays between gustatory neurons and higher brain centers 17,19,72,73 .…”

Section: Discussionmentioning

confidence: 99%

“…NMU peptides and their receptors are widely expressed in memory centers including the vertebrate hippocampus and the insect mushroom bodies [13][14][15]19 . Central administration of NMU peptides alleviates inflammationinduced amnesia 20,21 and also affects reward-related contextual learning 22 . Thus, NMU peptides may be neuromodulators of learning circuits, although the underlying mechanisms remain poorly defined.…”

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confidence: 99%

Neuromedin U signaling regulates retrieval of learned salt avoidance in a C. elegans gustatory circuit

et al. 2020

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Learning and memory are regulated by neuromodulatory pathways, but the contribution and temporal requirement of most neuromodulators in a learning circuit are unknown. Here we identify the evolutionarily conserved neuromedin U (NMU) neuropeptide family as a regulator of C. elegans gustatory aversive learning. The NMU homolog CAPA-1 and its receptor NMUR-1 are required for the retrieval of learned salt avoidance. Gustatory aversive learning requires the release of CAPA-1 neuropeptides from sensory ASG neurons that respond to salt stimuli in an experience-dependent manner. Optogenetic silencing of CAPA-1 neurons blocks the expression, but not the acquisition, of learned salt avoidance. CAPA-1 signals through NMUR-1 in AFD sensory neurons to modulate two navigational strategies for salt chemotaxis. Aversive conditioning thus recruits NMU signaling to modulate locomotor programs for expressing learned avoidance behavior. Because NMU signaling is conserved across bilaterian animals, our findings incite further research into its function in other learning circuits.

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“…The work of Gronewold et al demonstrated that dimerization of CPP sC18 promoted increased cellular uptake (mainly direct penetration) and tumour cell selectivity, depending on the composition of target membrane (MCF-7 cancer cells) [61]. Another important topic is the CPP’s lack of selectivity, which can be addressed by the incorporation of sequences of targeting [54,62,63] to specific receptors [53] and the use of mRNA display technology to design tumour lineage-homing peptides [22]. Furthermore, incorporation or conjugation of CPPs with complex structures such as NP [10,64], micelles [13] or liposomes [14] promotes stability, bioavailability and in vivo efficiency of CPPs.…”

Section: Cell-penetrating Peptidesmentioning

confidence: 99%

Combination of Cell-Penetrating Peptides with Nanoparticles for Therapeutic Application: A Review

2019

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Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid residues capable of penetrating biological barriers and cellular membranes. Furthermore, CPP have become an alternative strategy to overcome some of the current drug limitations and combat resistant strains since CPPs are capable of delivering different therapeutic molecules against a wide range of diseases. In this review, we address the recent conjugation of CPPs with nanoparticles, which constitutes a new class of delivery vectors with high pharmaceutical potential in a variety of diseases.

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Intranasal administration of neuromedin U derivatives containing cell-penetrating peptides and a penetration-accelerating sequence induced memory improvements in mice

Cited by 15 publications

References 32 publications

Neuromodulatory pathways in learning and memory: Lessons from invertebrates

Neuromodulatory pathways in learning and memory: Lessons from invertebrates

Neuromedin U signaling regulates retrieval of learned salt avoidance in a C. elegans gustatory circuit

Combination of Cell-Penetrating Peptides with Nanoparticles for Therapeutic Application: A Review

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