Intranasal administration of oxytocin: Behavioral and clinical effects, a review

Veening, Jan G.; Olivier, Berend

doi:10.1016/j.neubiorev.2013.04.012

Cited by 154 publications

(142 citation statements)

References 472 publications

(617 reference statements)

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“…Abnormalities in emotion recognition are central to numerous psychiatric conditions including ASD [96][97][98][99][100] and deficits in OT and insular cortex activity and connectivity are well documented correlates of symptom severity for many of these conditions 46,101,102 . Our results suggest that disruption of insula function may be key to pathophysiology in behaviors that depend upon social decisions regarding the emotions of others.…”

Section: Discussionmentioning

confidence: 99%

Insular Cortex Mediates Approach and Avoidance Responses to Social Affective Stimuli

Rogers

Varela

Gribbons

et al. 2017

Preprint

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Social animals detect the affective states of others and utilize this information to orchestrate appropriate social interactions. Social affective behaviors include cooperation, reproductive acts and avoiding sick individuals. In a social affective behavioral test in which experimental adult male rats were given the choice to interact with either naive or stressed conspecifics, the experimental rats demonstrated both approach and avoidant behaviors towards the conspecific, depending upon the age of the conspecific; experimental adult rats approached the stressed juvenile but avoided the stressed adult. Optogenetic inhibition of the insular cortex, a region anatomically positioned to contribute to social cognition, disrupted these behaviors. Receptors for the social nonapeptide oxytocin (OT) are found in high density within the insular cortex and here oxytocin increased intrinsic excitability and synaptic efficacy in acute insular cortex slices. Blockade of oxytocin receptors (OTRs) in the insula eliminated the effect of conspecific stress on approach behavior, while insular administration of OT recapitulated the behaviors typically observed in response to stressed conspecifics. Network analysis using Fos immunoreactivity identified functional connectivity between the insular cortex and the network of regions involved in social decision making. These results implicate insular cortex as a novel target of OT and suggest that insula is a key component in the circuit underlying age-dependent social responses to stressed conspecifics.Social animals, including humans, have an enormous repertoire of behavioral expressions that provide for the transmission of one's affective state to other members of the group 1-3 . Sensory and perceptive systems in the "social decision-making network" (SDMN) which consists of the social brain network 4 and the mesolimbic reward system 5 allow one to appraise these social stimuli and integrate them with past experiences, situational, and somatic factors to shape specific behavioral responses 6 . In addition to the SDMN, growing evidence implicates insular cortex in responding to socioemotional stimuli in humans. When tasked to identify the emotion of another from a facial expression, or to observe another suffer a painful stimulation, a reliable neural correlate is relative increase in the blood oxygen level dependent (BOLD) signal in the insular cortex 7,8 . Accordingly, emotion recognition and empathic deficits have been reported among individuals with insular cortex lesions [9][10][11][12] . Empathic processes are also disrupted in autism spectrum 1 Department of Psychology, Boston College, Chestnut Hill, MA 02467, USA 2 These authors made equal contributions to this work. *Corresponding Author: John P. Christianson, Department of Psychology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467 USA, Email: j.christianson@bc.edu, Phone: +1-617-552-3970.A note about the preprint. This manuscript was submitted to bioRxiv.org after multiple rounds of peer review. The manuscrip...

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Section: Discussionmentioning

confidence: 99%

Insular Cortex Mediates Approach and Avoidance Responses to Social Affective Stimuli

Rogers

Varela

Gribbons

et al. 2017

Preprint

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“…Similar to human (30) and recent nonhuman primate studies (31), the OT treatment was administered nasally, a minimally stressful method. One of the main technical issues of this method is whether the exogenous OT is able to cross the blood-brain barrier and exert direct effect on the brain.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin promotes social bonding in dogs

Romero

Nagasawa

Mogi

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

199

172

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Recent evidence suggests that enduring social bonds have fitness benefits. However, very little is known about the neural circuitry and neurochemistry underlying the formation and maintenance of stable social bonds outside reproductive contexts. Oxytocin (OT), a neuropeptide synthetized by the hypothalamus in mammals, regulates many complex forms of social behavior and cognition in both human and nonhuman animals. Animal research, however, has concentrated on monogamous mammals, and it remains unknown whether OT also modulates social bonds in nonreproductive contexts. In this study we provide behavioral evidence that exogenous OT promotes positive social behaviors in the domestic dog toward not only conspecifics but also human partners. Specifically, when sprayed with OT, dogs showed higher social orientation and affiliation toward their owners and higher affiliation and approach behaviors toward dog partners than when sprayed with placebo. Additionally, the exchange of sociopositive behaviors with dog partners triggered the release of endogenous OT, highlighting the involvement of OT in the development of social relationships in the domestic dog. These data provide new insight into the mechanisms that facilitate the maintenance of close social bonds beyond immediate reproductive interest or genetic ties and complement a growing body of evidence that identifies OT as one of the neurochemical foundations of sociality in mammalian species.cooperative bonds | cooperative mechanisms A ccording to behavioral ecology theory, sociability evolved either to reduce individuals' risk from predation or to increase individuals' ability to find and defend food (1). New evidence from a range of mammalian species, however, shows that competitive success and reproductive performance of social individuals are affected by the nature and quality of the social bonds they form, suggesting that sociability is adaptive in its own right (2, 3). The impact of social bonds on individuals' fitness extends beyond the benefits derived from associations directly related to mating and parental care (4). For example, in baboons (Papio hamadryas ursinus) (2, 3), house mice (Mus musculus) (5), rats (Rattus norvegicus) (6), horses (Equus equus) (7), and bottlenose dolphins (Tursiops truncatus) (8), individuals that maintain strong, enduring same-sex bonds experience a higher longevity or offspring survival than individuals with weaker bonds. These data parallel evidence from human studies that show that the quality and quantity of individuals' social relationships is associated not only with better mental health but also with reduced mortality (9).Beside the above-mentioned fitness benefits of social integration, very little is known about the neural circuitry and neurochemistry underlying the formation and maintenance of social bonds outside reproductive contexts. Although it is likely that brain systems that motivate animals to establish individualized relationships with other group members first evolved to mobilize the maternal care necessary f...

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“…administration has come to light as an effective and noninvasive means to circumvent the BBB for a variety of substances, including polypeptides, liposomes, virus vectors for gene therapy, and stem cells (Dhuria et al, 2010;Lochhead and Thorne, 2012a). These substances not only reach the brain tissue, but bioactive compounds such as insulin (Reger et al, 2008;Benedict et al, 2011;Craft et al, 2012), oxytocin (Veening and Olivier, 2013), and leptin (Schulz et al, 2012) do so in levels sufficient to cause significant behavioral changes in both patients and animal models of disease.…”

Section: I] ([ 125mentioning

confidence: 99%

Intranasal Administration as a Route for Drug Delivery to the Brain: Evidence for a Unique Pathway for Albumin

Falcone

Salameh

Xiang³

et al. 2014

J Pharmacol Exp Ther

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Intranasal administration of oxytocin: Behavioral and clinical effects, a review

Cited by 154 publications

References 472 publications

Insular Cortex Mediates Approach and Avoidance Responses to Social Affective Stimuli

Insular Cortex Mediates Approach and Avoidance Responses to Social Affective Stimuli

Oxytocin promotes social bonding in dogs

Intranasal Administration as a Route for Drug Delivery to the Brain: Evidence for a Unique Pathway for Albumin

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