Intranasal administration of probiotic <i>Lactobacillus rhamnosus</i> GG prevents birch pollen‐induced allergic asthma in a murine model

Spacova, Irina; Petrova, Mariya; Fremau, Astrid; Pollaris, Lore; Vanoirbeek, Jeroen; Ceuppens, Jan L.; Seys, Sven; Lebeer, Sarah

doi:10.1111/all.13502

Cited by 104 publications

(84 citation statements)

References 39 publications

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“…Alternatively, the association between posthospitalization increases in Moraxella or Streptococcus species abundance and recurrent wheezing might be causal (ie, microbiota might influence host immune response to viral infection). 23,29,30 If true, influencing microbiome reassembly after hospitalization for bronchiolitis either with antibiotics 22,23 or, preferably, with intranasal administration of protective species 31 might be an approach to help prevent asthma in this high-risk group. This study has potential limitations.…”

Section: Discussionmentioning

confidence: 99%

Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing

Mansbach

Luna

Shaw

et al. 2020

Journal of Allergy and Clinical Immunology

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Background: The role of the airway microbiome in the development of recurrent wheezing and asthma remains uncertain, particularly in the high-risk group of infants hospitalized for bronchiolitis. Objective: We sought to examine the relation of the nasal microbiota at bronchiolitis-related hospitalization and 3 later points to the risk of recurrent wheezing by age 3 years. Methods: In 17 US centers researchers collected clinical data and nasal swabs from infants hospitalized for bronchiolitis. Trained parents collected nasal swabs 3 weeks after hospitalization and, when healthy, during the summer and 1 year after hospitalization. We applied 16S rRNA gene sequencing to all nasal swabs. We used joint modeling to examine the relation of longitudinal nasal microbiota abundances to the risk of recurrent wheezing. Results: Among 842 infants hospitalized for bronchiolitis, there was 88% follow-up at 3 years, and 31% had recurrent wheezing. The median age at enrollment was 3.2 months (interquartile range, 1.7-5.8 months). In joint modeling analyses adjusting for 16 covariates, including viral cause, a 10% increase in relative abundance of Moraxella or Streptococcus species 3 weeks after day 1 of hospitalization was associated with an increased risk of recurrent wheezing (hazard ratio [HR] of 1.38 and 95% highdensity interval [HDI] of 1.11-1.85 and HR of 1.76 and 95% HDI of 1.13-3.19, respectively). Increased Streptococcus species abundance the summer after hospitalization was also associated with a greater risk of recurrent wheezing (HR, 1.76; 95% HDI,. Conclusions: Enrichment of Moraxella or Streptococcus species after bronchiolitis hospitalization was associated with recurrent wheezing by age 3 years, possibly providing new avenues to ameliorate the long-term respiratory outcomes of infants with severe bronchiolitis. (J Allergy Clin Immunol 2020;145:518-27.)

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Section: Discussionmentioning

confidence: 99%

Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing

Mansbach

Luna

Shaw

et al. 2020

Journal of Allergy and Clinical Immunology

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“…Probiotic applications have been shown to impact effector and regulatory T‐cell responses in airway disease, resulting in the restoration of the Th1/Th2 immune balance, and/or stimulation of regulatory cytokine production and the regulatory T‐cell (Treg) subset . This typically leads to a reduction in lung Th2 inflammatory cytokine levels (eg, IL‐5 and IL‐13) and the attenuation of AHR, as recently demonstrated for preventive intranasal administration of L. rhamnosus GG in a mouse model of birch pollen–induced allergic asthma . Additional immunomodulatory properties of probiotics in airway disease, including the stimulation of mucosal IgA levels and allergen‐specific B‐ and T‐cell responses, are well described elsewhere …”

Section: Probiotic Interactions With the Immune Systemmentioning

confidence: 97%

“…The administration route of these probiotics is typically oral, via drinking water or food, or through intragastric intubation . More recently, intranasal administration of probiotic bacteria has been increasingly explored in different mice studies . In the study of Spacova et al, the authors demonstrated that intranasal administration of L. rhamnosus GG attenuated birch pollen–induced asthma in mice .…”

Section: Clinical Application Of Probiotics For the Airwaysmentioning

confidence: 99%

Probiotics for the airways: Potential to improve epithelial and immune homeostasis

Martens

Pugin

Boeck

et al. 2018

Allergy

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Probiotics are live microorganisms that, when administered in adequate amounts, confer health benefit on the host. The therapeutic effects of probiotics have been mostly studied in the gastrointestinal tract, but recent evidence points toward the potential of these bacteria to prevent and/or treat chronic airway diseases. In this review, possible mechanisms of action of probiotics in the airways are described, with a particular focus on their capacity to modulate the epithelial barrier function and their mode of interaction with the immune system. Indeed, probiotic bacteria, mostly lactobacilli, can promote the expression and regulation of tight junctions and adherence junctions, resulting in the restoration of a defective epithelial barrier. These bacteria interact with the epithelial barrier and immune cells through pattern recognition receptors, such as Toll-like receptors, which upon activation can stimulate or suppress various immune responses. Finally, the clinical potential of probiotics to treat inflammatory diseases of the upper and lower respiratory tract, and the difference between their mode of application (eg, oral or nasal) are discussed here.

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“…Intranasale Gabe von Lactobacillus rhamnosus führte zunächst zu einer vorübergehenden Kolonisierung in den oberen Luftwegen bei Mäusen und reduzierte präventiv die Symptome einer künstlich induzierten Birkenpollenallergie mit reduzierter bronchialer Hyperreaktivität. In der BAL fand man weniger Eosinophile und weniger IL-5 und IL-13 im Vergleich zu einer Kontrollgruppe (Spacova et al 2018).…”

Section: Im Vergleich Zu Placebo Single-probiotikum Kombinationsprobiunclassified

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2020

Allergieprävention

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Intranasal administration of probiotic Lactobacillus rhamnosus GG prevents birch pollen‐induced allergic asthma in a murine model

Abstract: Intranasally administered L. rhamnosus GG prevents the development of cardinal features of birch pollen-induced allergic asthma in a strain-specific manner.

Cited by 104 publications

References 39 publications

Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing

Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing

Probiotics for the airways: Potential to improve epithelial and immune homeostasis

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