Intranasal Capsaicin in Management of Nonallergic (Vasomotor) Rhinitis

Singh, Umesh; Bernstein, Jonathan A.

doi:10.1007/978-3-0348-0828-6_6

Cited by 12 publications

(11 citation statements)

References 80 publications

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“…A recent study showed that higher concentration of capsaicin in patches provided better relief of neuropathic and chronic pain [ 58 ]. Topical treatment with capsaicin solution may also reduce symptoms in non-allergic chronic rhinitis [ 59 ]. A current study found, in such patients, increased levels of substance P in nasal lavage and overexpression of TRPV1 in nasal mucosa and treatment with topical capsaicin decreased symptoms and lowered nasal hyperreactivity [ 60 ].…”

Section: Trp Ion Channels In Chronic Coughmentioning

confidence: 99%

TRPV1 and TRPM8 in Treatment of Chronic Cough

Millqvist

2016

Pharmaceuticals

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Chronic cough is common in the population, and among some there is no evident medical explanation for the symptoms. Such a refractory or idiopathic cough is now often regarded as a neuropathic disease due to dysfunctional airway ion channels, though the knowledge in this field is still limited. Persistent coughing and a cough reflex easily triggered by irritating stimuli, often in combination with perceived dyspnea, are characteristics of this disease. The patients have impaired quality of life and often reduced work capacity, followed by social and economic consequences. Despite the large number of individuals suffering from such a persisting cough, there is an unmet clinical need for effective cough medicines. The cough treatment available today often has little or no effect. Adverse effects mostly follow centrally acting cough drugs comprised of morphine and codeine, which demands the physician’s awareness. The possibilities of modulating airway transient receptor potential (TRP) ion channels may indicate new ways to treat the persistent cough “without a reason”. The TRP ion channel vanilloid 1 (TRPV1) and the TRP melastin 8 (TRPM8) appear as two candidates in the search for cough therapy, both as single targets and in reciprocal interaction.

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Section: Trp Ion Channels In Chronic Coughmentioning

confidence: 99%

TRPV1 and TRPM8 in Treatment of Chronic Cough

Millqvist

2016

Pharmaceuticals

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“…In chili pepper, more than 200 active constituents have been identified and some of its active constituents play multiple roles in the whole body [27]. Capsaicin, as a major active compound from chili pepper, has been established for its numerous beneficial roles in the human organism, including the treatment of pain inflammation, rheumatoid arthritis [28], and vasomotor rhinitis (Figure 1) [29]. Furthermore, capsaicin has proven an effective anti-cancer agent.…”

Section: An Overview Of Chili Peppers and Capsaicinmentioning

confidence: 99%

Dietary capsaicin and its anti-obesity potency: from mechanism to clinical implications

et al. 2017

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Obesity is a growing public health problem, which has now been considered as a pandemic non-communicable disease. However, the efficacy of several approaches for weight loss is limited and variable. Thus, alternative anti-obesity treatments are urgently warranted, which should be effective, safe, and widely available. Active compounds isolated from herbs are similar with the practice of Traditional Chinese Medicine, which has a holistic approach that can target to several organs and tissues in the whole body. Capsaicin, a major active compound from chili peppers, has been clearly demonstrated for its numerous beneficial roles in health. In this review, we will focus on the less highlighted aspect, in particular how dietary chili peppers and capsaicin consumption reduce body weight and its potential mechanisms of its anti-obesity effects. With the widespread pandemic of overweight and obesity, the development of more strategies for the treatment of obesity is urgent. Therefore, a better understanding of the role and mechanism of dietary capsaicin consumption and metabolic health can provide critical implications for the early prevention and treatment of obesity.

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“…There is increasing interest in using capsaicin as a therapeutic alternative for different diseases ( 18 , 19 ) due to its pleiotropic pharmacological effects on various physiological systems, with an emphasis on pain as well as neuroscience, cardiovascular, respiratory, cancer, and urinary systems studies ( 20 ). In terms of the pharmacokinetics, capsaicin has high oral bioavailability and skin absorption ( 21 ), making its topical application effective in various musculoskeletal or neuropathic pain conditions such as arthritis ( 22 ), shingles ( 23 ), vasomotor rhinitis ( 24 ), vasogenic facial pain ( 25 ). It is also used for treating urinary incontinence, chronic kidney disease-associated pruritus, and postoperative nausea and vomiting in acupoint therapy ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

et al. 2022

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Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in the genus Capsicum. Due to its numerous biological effects, there has been extensive and increasing research interest in capsaicin, resulting in increased scientific publications in recent years. Therefore, an in-depth bibliometric analysis of published literature on capsaicin from 2001 to 2021 was performed to assess the global research status, thematic and emerging areas, and potential insights into future research. Furthermore, recent research advances of capsaicin and its combination therapy on human cancer as well as their potential mechanisms of action were described. In the last two decades, research outputs on capsaicin have increased by an estimated 18% per year and were dominated by research articles at 93% of the 3753 assessed literature. In addition, anti-cancer/pharmacokinetics, cytotoxicity, in vivo neurological and pain research studies were the keyword clusters generated and designated as thematic domains for capsaicin research. It was evident that the United States, China, and Japan accounted for about 42% of 3753 publications that met the inclusion criteria. Also, visibly dominant collaboration nodes and networks with most of the other identified countries were established. Assessment of the eligible literature revealed that the potential of capsaicin for mitigating cancer mainly entailed its chemo-preventive effects, which were often linked to its ability to exert multi-biological effects such as anti-mutagenic, antioxidant and anti-inflammatory activities. However, clinical studies were limited, which may be related to some of the inherent challenges associated with capsaicin in the limited clinical trials. This review presents a novel approach to visualizing information about capsaicin research and a comprehensive perspective on the therapeutic significance and applications of capsaicin in the treatment of human cancer.

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Intranasal Capsaicin in Management of Nonallergic (Vasomotor) Rhinitis

Cited by 12 publications

References 80 publications

TRPV1 and TRPM8 in Treatment of Chronic Cough

TRPV1 and TRPM8 in Treatment of Chronic Cough

Dietary capsaicin and its anti-obesity potency: from mechanism to clinical implications

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

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