Intranasal corticosteroid use is associated with lower rates of bacterial recovery in chronic rhinosinusitis

Abstract

The results suggest a possible role of INCS in the management of post-ESS disease.

Bacterial biofilms and the pathophysiology of chronic rhinosinusitis

“…Bacteria identified in this study as well as the other CRS biofilm studies have generally found that 70% of the infections identified were secondary to Pseudomonas aeruginosa or Staphylococcus aureus, and they were often polymicrobial in nature. These results demonstrate that biofilms are present in most patients with CRS and that the bacteriology of these biofilms may not differ radically from the current paradigm for the bacteriology of CRS [23,24]. However, given our general understanding of the propensity of bacteria to form a biofilm, these findings are not completely unexpected.…”

The role of bacterial biofilms and the pathophysiology of chronic rhinosinusitis

“…In numerous studies of the bacteriology of CRS done with conventional culture methods, Staphylococcus aureus has been implicated as one of the most common bacteria to colonize the paranasal sinuses in both asymptomatic postoperative and operative patients with CRS [35,36]. As such, this organism has been demonstrated to occur in the form of a biofilm in patients with CRS, as have coagulase-negative Staphylococcus (CNS), P. aeruginosa, and H. influenzae [37][38][39][40].…”

Effects of Intranasal Steroid Spray in Bacterial Culture of Chronic Rhinosinusitis

“…[24][25][26] However, the adverse effects of the immunosuppressive effect of GCs have also been a concern in the treatment of CRS. 12 Our results showed that INCS, which was used continuously for one month in CRS patients, did not change the bacterial culture rate, distribution of bacteria, or antibiotic sensitivity. This suggests that using INCS is relatively safe for CRS patients.…”

“…A previous study showed that topical intranasal corticosteroids could decrease the recovery rate of bacteria from the ethmoid sinuses in cases undergoing sinus surgery for chronic rhinosinusitis. 12 This means that INCS has an anti-inflammatory effect in such patients. From our results, the bacterial culture rate and drug sensitivity did not change after using INCS for one month in CRS patients with nasal polyposis.…”

“…8 A previous study found that treatment with a topical intranasal corticosteroid (INCS) was associated with a lower recovery rate of bacteria from the ethmoid sinuses in cases undergoing sinus surgery for chronic rhinosinusitis. 12 13 However, the effects of INCS are unclear with regard to bacterial culture and drug resistance in the cases of CRS with nasal polyposis. In this study, we investigate whether the use of a topical corticosteroid influences the rate of bacterial recovery and drug sensitivity in CRS with nasal polyposis.…”