Intranasal dexmedetomidine in combination with patient‐controlled sedation during upper gastrointestinal endoscopy: a randomised trial

Abstract

Intranasal dexmedetomidine with PCS propofol and alfentanil confers deeper perioperative clinical sedation with significantly less use of additional sedatives during upper gastrointestinal endoscopy.

Intranasal Dexmedetomidine in Termination of First Trimester Pregnancy of Suction Evacuation

“…In Cheung's study, intranasal dexmedetomidine 1.5 μg/kg with patient-controlled-sedation (PCS) of propofol and alfentanil offered deeper perioperative clinical sedation with significantly less use of additional sedatives during upper gastrointestinal endoscopy [11]. Similarly, in our study, consumption of propofol in group DP was significantly lower than that in group P and group SP (P<0.001 and P<0.01, respectively).…”

“…Dexmedetomidine has been used as a sedative agent in intensive care unit and an anesthetic adjunct in surgery [7][8][9]. Recently, more and more studies propose it as a sedative agent in moderate sedation for clinical surgeries/procedures [10][11][12][13]. Intravenous infusion of dexmedetomidine is commonly used, but rapid administration or bolus might cause bradycardia and hypotension [14].…”

“…Therefore, different routes of administration and multimodal analgesia are suggested in future studies. Intranasal dexmedetomidine is convenient and non-invasive, and it provides sedative and analgesic effects during surgery/procedure for both children and adults without any adverse effects of respiratory depression, bradycardia, or discomfort of intranasal drips [10,11,19,20]. The number of clinical trials those have evaluated the clinical use of intranasal dexmedetomidine in sedation for surgery and clinical procedures is limited.…”

Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine

“…formulation is also efficacious when administered by the intranasal route in both children 4e8 and adults. 9,10 Since this is not associated with any unpleasant sensation, there is increasing use for paediatric premedication and procedural sedation. 5,11 There is one report on the bioavailability (65%) of intranasal dexmedetomidine in healthy volunteers, 12 performed with a special nasal pump and a highly concentrated veterinary formulation of dexmedetomidine (84 mg in 0.2 ml).…”

A Novel Use of a Novel Drug: Preoperative Nasal Preparation with Dexmedetomidine for Transnasal Transsphenoidal Neurosurgery Approach in Skull Base Neurosurgery

“…11 Intranasal DEX is convenient, effective, noninvasive, and also has useful analgesic and sedative effects in surgical procedures. 12,13 Cheung's research has shown that intranasal DEX 1 and 1.5 μg/kg in surgical procedures produced significant sedation and less postoperative pain. 13,14 DEX has vasoconstrictive effects on peripheral blood vessels.…”