Intranasal <i>Helicobacter pylori</i> infection in patients with chronic rhinosinusitis with polyposis

Šiupšinskienė, Nora; Katutiene, I; Jonikiene, V; Jančiauskas, Dainius; Vaitkus, Saulius

doi:10.1017/s0022215118001299

Cited by 15 publications

(18 citation statements)

References 25 publications

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“…The finding of RFS > 7 was pathologically stated by Siupsinskiene in 2018. The study found a non-significant result (p=0.48) for 64.3% of CRS patients who were proven to have reflux (Siupsinskiene et al, 2018).…”

Section: Discussionmentioning

confidence: 74%

Nasal pepsin A

Buana¹,

Kristyono²,

Juniati³

2022

ijhs

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Laryngopharyngeal reflux (LPR) can contribute to chronic rhinosinusitis (CRS). Pepsin is believed to be one of the causes of CRS. Pepsin can be a promising biomarker because it is only produced by gastric parietal cells, so it can explain the correlation of CRS with LPR. This study aims to determine the relationship between CRS and LPR based on nasal pepsin examination. The design in this study is a cross-sectional prospective with statistical analysis using the Chi-square method. The research sample were patients with complaints of runny nose and nasal congestion within 12 weeks and met the inclusion and exclusion criteria. All samples were subjected to nasal endoscopy and fiber optic laryngoscope and have Reflux Symptoms Index (RSI) > 13. Specimens from the samples were obtained through the nasal washing method, and pepsin was evaluated using the PepTest lateral flow device. A total of 35 samples in this study consisted of 13 men (37.14%) and 22 women (62.85%). The highest age in the CRS group was the 18-40-year-old group with 16 (64%). A total of 20 (83.3%) CRS patients were positive for pepsin p=0.04 (p<0.05).

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Section: Discussionmentioning

confidence: 74%

Nasal pepsin A

Buana¹,

Kristyono²,

Juniati³

2022

ijhs

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“…A study by Siupsinskiene et al . in this month's issue of The Journal examines the relationship between intranasal Helicobacter pylori infection and nasal polyps 7 . This work follows their previous study published last year, which demonstrated an association between H pylori infection and chronic tonsillitis and laryngopharyngeal reflux 8 .…”

mentioning

confidence: 74%

Ménière's disease: ‘a riddle wrapped in a mystery inside an enigma’. Has the key been found?

Fishman¹,

Fisher²,

Hussain³

2018

J. Laryngol. Otol.

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“…Six studies which provided miscellaneous data about the association between reflux and sinonasal disorders that were not formally defined as CRS were excluded. [30][31][32][33][34][35]…”

Section: Resultsmentioning

confidence: 99%

Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review

Lechien

Saussez

Hopkins

2023

Clinical Otolaryngology

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Objective: To investigate the association between laryngopharyngeal reflux (LPR), gastroesophageal reflux disease (GERD) and recalcitrant chronic rhinosinusitis (CRS).Data Sources: PubMed, Cochrane Library and Scopus.Review Methods: Three investigators searched the specified databases for studies investigating the relationship between LPR, GERD and recalcitrant CRS with or without polyposis. The following outcomes were investigated with PRISMA criteria: age; gender; reflux and CRS diagnosis; association outcomes and potential treatment outcomes. The authors performed a bias analysis of papers and provided recommendations for future studies.Results: A total of 17 studies investigated the association between reflux and recalcitrant CRS. According to pharyngeal pH monitoring, 54% of patients with recalcitrant CRS reported hypo or nasopharyngeal acid reflux events. The number of hypo-and nasopharyngeal acid reflux events was significantly higher in patients compared to healthy individuals in 4 and 2 studies, respectively. Only one study did not report intergroup differences. The proportion of GERD was significantly higher in CRS patients compared to controls, with a prevalence ranging from 32% to 91% of cases.No author considered nonacid reflux events. There was significant heterogeneity in the inclusion criteria; definition of reflux and association outcomes, limiting the ability to draw clear conclusions. Pepsin was found in sinonasal secretions more frequently in CRS patients than controls. Conclusion:Laryngopharyngeal reflux and GERD may be contributing factors of CRS therapeutic resistance, but future studies are needed to confirm the association considering nonacid reflux events.

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Intranasal Helicobacter pylori infection in patients with chronic rhinosinusitis with polyposis

Abstract: H pylori infection is potentially related to chronic rhinosinusitis with polyposis. Further research is needed to clarify the role of H pylori as a risk factor for the development of sinonasal diseases and to examine its link with laryngopharyngeal reflux.

Cited by 15 publications

References 25 publications

Nasal pepsin A

Nasal pepsin A

Ménière's disease: ‘a riddle wrapped in a mystery inside an enigma’. Has the key been found?

Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review

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