Intranasal Interferon for Contact Prophylaxis Against Common Cold in Families

Herzog, Christian; Just, M; Berger, Rosmarie; Havas, L; Fernex, M

doi:10.1016/s0140-6736(83)90470-1

Cited by 17 publications

(8 citation statements)

References 6 publications

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“…Interferon (IFN) is a human glycoprotein that interferes with viral infectivity by triggering the intracellular production of antiviral proteins. The broad antiviral activity of interferon makes it of considerable utility for the resolution and prophylaxis of respiratory viral infections, including rhinovirus, influenza A and B, parainfluenza, adenovirus and coronavirus [199] , [200] , [201] , [202] , [203] , [204] , [205] , [206] . The advancement of recombinant protein expression and purification technology has enabled the routine production of large amounts of purified human interferon protein at relatively low cost [207] .…”

Section: Inhaled Antiviralsmentioning

confidence: 99%

“…Intranasal interferon is very effective in preventing rhinovirus colds via post-exposure prophylaxis of family contacts; however, it has not proven to be effective for the treatment of established infections [199] , [200] , [201] , [202] , [203] , [204] , [205] , [206] . Intranasal IFN-α2 at a dose of 1 × 10 6 international units (IU) twice daily for 4 weeks provided approximately 75–87% protection against rhinovirus respiratory infections (responsible for ~ 50% of common colds) [199] , [200] , [201] , [208] , [209] , [210] .…”

Section: Inhaled Antiviralsmentioning

confidence: 99%

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Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

Velkov

Rahim

Zhou

et al. 2015

Advanced Drug Delivery Reviews

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One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it affords delivery of sufficient therapeutic dosages directly to the primary site of infection, while minimizing the risks of systemic toxicity or avoiding potential suboptimal pharmacokinetics/pharmacodynamics associated with systemic drug exposure. This review provides an up-to-date treatise of approved and novel developmental inhaled anti-infective agents, with particular attention to effective strategies for their use, pulmonary pharmacokinetic properties and safety.

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Section: Inhaled Antiviralsmentioning

confidence: 99%

Section: Inhaled Antiviralsmentioning

confidence: 99%

Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

Velkov

Rahim

Zhou

et al. 2015

Advanced Drug Delivery Reviews

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“…Postexposure prophylaxis Another logical strategy for preventing common colds is postexposure prophylaxis of family contacts. Investigators at several institutions have recently completed long-term double-blind, placebo-controlled studies to determine the usefulness of intranasal interferon in preventing illness in the household contacts of family members with respiratory illness [42,43]. Whereas low doses of rIFN-aA (0.3 or 1.5 x 10 6 IU/day for 5 days) did not appear to prevent transmission of colds [43], higher doses of rIFN-_2 (5 x 10 6 IU/day for 7 days) significantly reduced respiratory illness occurrence in family contacts [42].…”

Section: Treatmentmentioning

confidence: 99%

Clinical applications of antiviral agents for chemophrophylaxis and therapy of respiratory viral infections

Hayden

1985

Antiviral Research

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“…Investigators at several institutions have recently completed long-term double-blind, placebo-controlled studies to determine the usefulness of intranasal interferon in preventing illness in the household contacts of family members with respiratory illness [42,43]. Whereas low doses of rIFN-aA (0.3 or 1.5 x 10 6 IU/day for 5 days) did not appear to prevent transmission of colds [43], higher doses of rIFN-_2 (5 x 10 6 IU/day for 7 days) significantly reduced respiratory illness occurrence in family contacts [42]. Interferon was also well tolerated when used in this manner, and evidence of cumulative toxicity was not found.…”

Section: Postexposure Prophylaxismentioning

confidence: 99%

Activated interferon system in healthy homosexual men

et al. 1985

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More than 50% of a group of healthy homosexuals in Israel were found to have an activated interferon (IFN) system as evidenced by markedly elevated blood IFN levels, increased in vitro production of IFN by unstimulated peripheral blood mononuclear cells and HuIFN-alpha and HuIFN-gamma production by appropriately stimulated cells, and a surprisingly high incidence of an antiviral state of cells. This pattern resembles that found in persons with acute viral illness, and is unlike that found in normal healthy controls. The type of IFN in the blood was found to be unusual in that it was mainly HuIFN-alpha, pH 2-labile, a type of IFN found in certain collagen diseases as well as in homosexual men suffering from Kaposi's sarcoma or lymphadenopathy. Natural killer (NK) cytotoxic activity was found to be somewhat lower than that found in normal controls, although no correlation was found between blood IFN levels and NK activity. Mean (2'-5')-oligoisoadenylate synthetase levels in cell extracts were intermediate between normal controls and patients with viral illness. Likewise no correlation was found between enzyme levels and blood IFN levels. The highly activated IFN system found in certain homosexuals, as well as the increased spontaneous production of IFN by unstimulated mononuclear cells, suggest the possibility of the presence of a virus, active or latent, in these individuals. This virus could be a retrovirus such as HTLV-III or LAV which have recently been isolated from AIDS patients. The special type of IFN present could be the response to a novel virus in an unusual situation. On the basis of recent reports, we speculate that homosexuals with highly activated IFN systems who produce pH 2-labile HuIFN-alpha could be at increased risk for developing AIDS.

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Intranasal Interferon for Contact Prophylaxis Against Common Cold in Families

Cited by 17 publications

References 6 publications

Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

Clinical applications of antiviral agents for chemophrophylaxis and therapy of respiratory viral infections

Activated interferon system in healthy homosexual men

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