Intranasal Midazolam for the Treatment of Seizures in Children in Rural India

Midazolam nasal spray to treat intermittent, stereotypic episodes of frequent seizure activity: pharmacology and clinical role, a comprehensive review

“…Between all three groups, the average time to seizure cessation was 4.66 minutes. 38 Intranasal midazolam was successful in controlling seizures within 5 minutes in 37 patients and between 5-10 minutes in 13 patients. 38 In 13 patients requiring repeat doses, 8 patients responded successfully.…”

“…38 Intranasal midazolam was successful in controlling seizures within 5 minutes in 37 patients and between 5-10 minutes in 13 patients. 38 In 13 patients requiring repeat doses, 8 patients responded successfully. The most common seizure type seen in the 50 patients included in the study was generalized tonic-clonic (46%), followed by complex partial seizures (32%).…”

“…The most common seizure type seen in the 50 patients included in the study was generalized tonic-clonic (46%), followed by complex partial seizures (32%). 38 There were no significant side effects due to administration of intranasal midazolam, but some difficulties were experienced by caregivers, including excessive nasal secretions and head movements.…”

“…A 2020 study assessed the use of intranasal midazolam for the treatment of seizures in children in rural India. 38 This study examined the effectiveness of intranasal midazolam for seizure cessation when given by caregivers in the home setting. A total of 50 children ranging from 6 months of age to 14 years old were included in the study.…”

“…Intranasal midazolam was administered by the caregiver at a dose of 0.2 mg/kg, with instructions to wait 3 minutes after seizure initiation to give the drug. 38 The 50 patients were divided into three groups, separated by age: group A included patients aged 6 months-4 years (13 patients), group B included patients aged 4-9 years (18 patients), and group C included patients aged 9-14 years (19 patients). Between all three groups, the average time to seizure cessation was 4.66 minutes.…”